DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk29 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_001097442.2	Gene:	ppk29 / 37844	FlyBaseID:	FBgn0034965	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001258952.1	Gene:	Scnn1b / 20277	MGIID:	104696	Length:	638	Species:	Mus musculus

Alignment Length:	387	Identity:	79/387 - (20%)
Similarity:	126/387 - (32%)	Gaps:	115/387 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SFTRMIYEYAFLNPNNIFTK---EPTKNTSYPYNFNILDIRRKMFPT------NCTECFKEIYFR 152
            |.|:.:.|:..|...|||::   :......|..:..||..   :|.|      |.|..|...|
Mouse   208 SATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILAC---LFGTEPCSHRNFTPIFYPDY-- 267

  Fly   153 GELVTDCEEIFKFHVTE-------MGYCFLANNLLDYDSIEEMPLRYSSLDNNRSLRLYMRSSVM 210
                .:| .||.:.:||       .|..|....:||....:.:|.    |.:....||.:.....
Mouse   268 ----GNC-YIFNWGMTEETLPSANPGTEFGLKLILDIGQEDYVPF----LASTAGARLMLHEQRT 323

  Fly   211 YKYEMYVNSPEDLPFFNSL-TYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCKFPSES----- 269
            |            ||.... .|.::...|:....|:::...    .||.|  .|......
Mouse   324 Y------------PFIREEGIYAMAGTETSIGVLVDKLQRK----GEPYS--PCTMNGSDVAIKN 370

  Fly   270 --SIEGFPYSFSACMSIIRSEFEMKTCDCSLF-----------NPKDRNESLYCGL-------QH 314
              |:....||..||:.....:..::.|.|..:           |.:|..:..||.|       |.
Mouse   371 LYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLPEGEKYCNNRDFPDWAYCYLNLQMSVTQR 435

  Fly   315 ADCLIKEGFATRVKEYVGSSTVCLPSCVEQQ----ISLVGVITENG------TLYNNNTQITEIQ 369
            ..||                ::|..||.:.|    ||:....:|..      .|.....|.:.|.
Mouse   436 ETCL----------------SMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNIT 484

  Fly   370 IASPPTVRYE--------RKVTQTKLDLIV----GIGSVAGLFFGASLLNLL---EIISYFI 416
            ::....|:..        |.:.::..:.||    .:|...|.:.|.|:|.|:   |||..||
Mouse   485 LSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFI 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk29	NP_001097442.2	ASC	123..415	CDD:279230	70/355 (20%)
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	79/387 (20%)
		deg-1	29..538	CDD:273309	74/377 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840