DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and KCNH7

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_011510411.1	Gene:	KCNH7 / 90134	HGNCID:	18863	Length:	1204	Species:	Homo sapiens

Alignment Length:	909	Identity:	413/909 - (45%)
Similarity:	543/909 - (59%)	Gaps:	147/909 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VQQCELYMSNNNI-------NDNAAKKPPVKEFKRNCPAKSNKFV----------EREL------ 60
            ||.|.:...|:..       ..:..:||...:|......|.:...          ||::
Human    36 VQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYH 100

  Fly    61 ---FSLMCNLNKIE-KKQVFVSDI-LINASMFDDKKESLARFPKNVS------------------ 102
               .:.:||.:.|. |.|..|:.: :||.....|.:.  |..|:.|:
Human   101 KNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNEN--AATPERVNPILPIKTVNRKFFGFKFP 163

  Fly   103 DHNTLVYHKFLRTRPTNDDEALKLKAGGKSKERPGTKITADCFFSPLLFKINNKRECLKK----- 162
            ....|.|.|  ::.|..|.:.:.:.:...|.:....|          .||...|..|...
Human   164 GLRVLTYRK--QSLPQEDPDVVVIDSSKHSDDSVAMK----------HFKSPTKESCSPSEADDT 216

  Fly   163 ---VKPMKGENAVETNGIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLLCSYDP 224
               ::|.|....|..:| ||:....:.:..:.:...::        .:.|:|..|..:.|||
Human   217 KALIQPSKCSPLVNISG-PLDHSSPKRQWDRLYPDMLQ--------SSSQLSHSRSRESLCS--- 269

  Fly   225 LRK----NNADLFQTHKGTSY------ECMFKNLKYNQ---AEKPTDNV----MGNSYDDMLDKE 272
            :|:    ::.:.|..|....:      |...:|:|.::   |..|.:::    :|::.|..|:|.
Human   270 IRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKVSRSWMAGGPFNHIKSSLLGSTSDSNLNKY 334

  Fly   273 ALLGS-----------KSEPKGQDPND----------------------MITSLGGNILLDQKLQ 304
            :.:..           |:|.|...|..                      .:.|||.::|.:.|||
Human   335 STINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQ 399

  Fly   305 NNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDL 369
            ....:|:|:||||||||||||:||:||:||||||||.|||||.:::.|:|.....:..|:.::||
Human   400 TPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDL 464

  Fly   370 IVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTT 434
            |||:.||:||:||||||:||..:||||.|.:||:||..||||||:|||:|||||:.||.:|||||
Human   465 IVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTT 529

  Fly   435 LIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAEKSIASKNIG 499
            |||||||||||||||||||:|||||||||||:|||..|.|||||||||||||||.|:...:..||
Human   530 LIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIG 594

  Fly   500 WLNSLAYDIQEPYFD-NRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVG 563
            ||:||...|.:.|.| :.:.|||||.:|:|||||||:||||||||||:|||::||.|:|||||:|
Human   595 WLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIG 659

  Fly   564 SLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDM 628
            ||||||||||||||||||||||||||.|||||:||||||||||||||||||||||||||||||||
Human   660 SLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDM 724

  Fly   629 NSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTS 693
            |.:|||||||||||||||||:.||..|.||..||.|||||.::|||||||||||.|||.|||||:
Human   725 NMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTA 789

  Fly   694 LYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLD 757
            |||::||||||.:...:| :|||||||||...:|...||||..||||||||:||:.|:|||:|||
Human   790 LYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLD 854

  Fly   758 SYPEFLESFVSNLVITYNMR---------------DDEHSGVDIKHRYLRAKSSDKMRSSPDIP 806
            .||||.:.|::||.:|:|:|               |.|.....::.|.|..:|..:..:|.:.|
Human   855 MYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDP 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	160/223 (72%)
		Ion_trans_2	<526..580	CDD:285168	45/53 (85%)
		CAP_ED	657..767	CDD:237999	73/110 (66%)
		Crp	666..>766	CDD:223736	67/100 (67%)
KCNH7	XP_011510411.1	PAS_9	29..134	CDD:290162	18/97 (19%)
		PAS	41..130	CDD:238075	15/88 (17%)
		Ion_trans	456..679	CDD:278921	160/222 (72%)
		Ion_trans_2	<622..676	CDD:285168	45/53 (85%)
		Crp	747..>884	CDD:223736	82/136 (60%)
		CAP_ED	753..864	CDD:237999	73/110 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145026
Domainoid	1	1.000	387	1.000	Domainoid score	I801
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm41065
orthoMCL	1	0.900	-	-		OOG6_100845
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5087
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.730