DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Cnga4

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_445948.2	Gene:	Cnga4 / 85258	RGDID:	619844	Length:	575	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	119/504 - (23%)
Similarity:	231/504 - (45%)	Gaps:	71/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 NYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLI 370
            :||:.|  |:...|..:::   ||:|:..|.|.....::|:.                ..::|..
  Rat    32 DYYYWW--LNTMVFPIMYN---LIIVVCRACFPDLQHSYLVA----------------WFVLDYT 75

  Fly   371 VDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGW-FLIDLVAAVPFDLLLVGSDTDETTT 434
            .|:.:::||.:.|.|.|: .|..:|...|.||..|:..| ||:||.:.||         ||....
  Rat    76 SDLLYLLDIGVRFHTGFL-EQGILVVDKGMIASRYVRTWSFLLDLASLVP---------TDAAYV 130

  Fly   435 LIG-LLKTARLLRLVRVARKIDRY------SEYGAAVLI--LLMATFILIAHWLACIWYAIGNAE 490
            .:| .:.|.||.|.:||.|..:.:      :.|..|..|  |::..|::| ||.:|:::|:
  Rat   131 QLGPHIPTLRLNRFLRVPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWNSCLYFAL---- 190

  Fly   491 KSIASKNIGW-LNSLAY-DIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEK 553
                |:.:|: .::..| |..:|.|:.      ::.:|:.:.||:...||:|| ....|:.:.|.
  Rat   191 ----SRYLGFGRDAWVYPDPAQPGFER------LRRQYLYSFYFSTLILTTVG-DTPLPDREEEY 244

  Fly   554 AFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQH 618
            .|.:...|:..:.:|:|.|::|::|..:.:..|.::.....|:::::...:...|.:|:.:::||
  Rat   245 LFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNKRLERRVIDWYQH 309

  Fly   619 AWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDI 683
            ........:..::|:..||.|:|::.:.::...|:....|.......|....||.:.....||:.
  Rat   310 LQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEY 374

  Fly   684 LVHRGDVLTSLYFIARGSIEIQRAGNI---VVLGKNDIFGENPCIYPTVGKSNG-----VVRALT 740
            :..:||:...:|.|..|.:.:.....:   .|||....||| ..|....|..:|     .:::|.
  Rat   375 VCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKSLG 438

  Fly   741 YCDIHKLHRDDLLDVLDSYPE---FLESFVSNLVITYNMRDDEHSGVDI 786
            |.|:..|.::||.:||..||:   .:|.....:::..|..|......:|
  Rat   439 YSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	62/234 (26%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	31/120 (26%)
		Crp	666..>766	CDD:223736	30/110 (27%)
Cnga4	NP_445948.2	Ion_trans	58..273	CDD:278921	64/256 (25%)
		P-loop_NTPase	116..>174	CDD:304359	19/66 (29%)
		IQ-type. /evidence=ECO:0000250	292..302		1/9 (11%)
		Crp	342..>519	CDD:223736	35/147 (24%)
		CAP_ED	348..464	CDD:237999	30/116 (26%)
		CLZ	464..535	CDD:293134	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840