DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Hcn1

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_445827.2	Gene:	Hcn1 / 84390	RGDID:	620688	Length:	902	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	138/512 - (26%)
Similarity:	239/512 - (46%)	Gaps:	69/512 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 WTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTF 375
            |.:..||.|:..||.|:||:::...:..|....|.. ||          .:.|.:|.::..|..|
  Rat   122 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFT-EQ----------TTTPWIIFNVASDTVF 175

  Fly   376 IVDIIINFRTTFVN-SQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV----GSDTDETTTL 435
            ::|:|:||||..|| ...|::..|..|.::||..||::|.::::|.|.:.:    |.|::...|.
  Rat   176 LLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTA 240

  Fly   436 IGL--------LKTARLLRLVRVARKIDRYSE-----YGAAVLIL----LMATFILIAHWLACIW 483
            ..|        |...|||||.|:.|.|.::.|     |..|..::    |:...:|:.||..|:.
  Rat   241 RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQ 305

  Fly   484 YAIGNAEKSIASKNIGW--LNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVA 546
            :.:...:.....   .|  ||.:..|             |...:|..||:...:.:..:|:|..|
  Rat   306 FLVPLLQDFPPD---CWVSLNEMVND-------------SWGKQYSYALFKAMSHMLCIGYGAQA 354

  Fly   547 PNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQR 611
            |.:.::...|:..|:||:..||...|:.:|:||.|.|...:|..:..:|.:::.||::|..:||:
  Rat   355 PVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQK 419

  Fly   612 LEEYFQHAWTYTNGI-DMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            :.:|::|  .|...| |..::|....:.|:.:|.....|||:.|...|:.|.|..:.|...|.:.
  Rat   420 IHDYYEH--RYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRF 482

  Fly   676 THAPPGDILVHRGDVLTSLYFIARG-SIEIQRAGNIVVLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            ....|||.::..|.|...:|||..| :..|.::...:.|.....||| .|:. |.|:....|||.
  Rat   483 EVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE-ICLL-TKGRRTASVRAD 545

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVS------------NLVITYNMRDDEHSGV 784
            |||.::.|..|:..:||:.||....:|.:            |.::....:.|.::||
  Rat   546 TYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGV 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	66/246 (27%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	34/110 (31%)
		Crp	666..>766	CDD:223736	31/100 (31%)
Hcn1	NP_445827.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75
		PLN03192	122..>609	CDD:215625	138/512 (27%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:O60741	347..351		1/3 (33%)
		CAP_ED	464..572	CDD:237999	34/109 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	858..902
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840