DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Cngb1

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_113997.2	Gene:	Cngb1 / 83686	RGDID:	621809	Length:	1338	Species:	Rattus norvegicus

Alignment Length:	693	Identity:	142/693 - (20%)
Similarity:	261/693 - (37%)	Gaps:	185/693 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PTNDDEALKLKAGGKSK------ERPGTKITAD------CFFSPLLFKINNK--------RECLK 161
            |:.||||.:|||...::      ..|.|...||      ...|.....||::        :|..:
  Rat   611 PSQDDEAEELKALSPAESPVVAWSDPTTPQEADGEDRAASTASQNSAIINDRLQELVKMFKERTE 675

  Fly   162 KVKPMKGENAVETNGIPLES--KPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRE--CDLLCSY 222
            |||    |..::.:....|.  |||..||........|..:.:        :|..|  ||:||
  Rat   676 KVK----EKLIDPDVTSDEESPKPSPAKKAPDSAPAQKPAEAE--------AAEEEHYCDMLC-- 726

  Fly   223 DPLRKNNADLFQTHKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPN 287
                                |.||...:...:                         .|:..||
  Rat   727 --------------------CKFKRRPWKMYQ-------------------------FPQSIDP- 745

  Fly   288 DMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQ 352
                           |.|..|..|...    ....|:|...::        |...||     .||
  Rat   746 ---------------LTNLMYILWLFF----VVLAWNWNCWLI--------PVRWAF-----PYQ 778

  Fly   353 RRNSKYINSDPIVIIDLIVDVTFIVDI-IINFRTTFVNSQDEVVSHPGRIAVHYL-SGWFLIDLV 415
            |.::.::    .:::|.:.|..:::|| :...|..||...| :::....:..:|| |..|.:||:
  Rat   779 RADNIHL----WLLMDYLCDFIYLLDITVFQMRLQFVKGGD-IITDKKEMRNNYLKSQRFKMDLL 838

  Fly   416 AAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSEYG---AAVL-------ILLMA 470
            ..:|.|.|.:            .|....||||.| ..|...:.|:.   .|:|       ::...
  Rat   839 CLLPLDFLYL------------KLGVNPLLRLPR-CLKYMAFFEFNNRLEAILSKAYVYRVIRTT 890

  Fly   471 TFILIA-HWLACIWYAIGNAEKSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTF 534
            .::|.: |..:|::| ..:|.:.|.|.:  |:    ||             .:.:.||...|:..
  Rat   891 AYLLYSLHLNSCLYY-WASAFQGIGSTH--WV----YD-------------GVGNSYIRCYYWAV 935

  Fly   535 TSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFI 599
            .:|.::| |...|.|..|..|.:.....|...::.:.|.:..::....:|...|.:.|....:::
  Rat   936 KTLITIG-GLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYM 999

  Fly   600 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPG 664
            .|::||..::.|::.::::.|.....:|.:.|:...|:.::.|:.:.:|..:::..|.|.    |
  Rat  1000 NFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQ----G 1060

  Fly   665 CLR--AFSL--KFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGN----IVVLGKNDIFGE 721
            |.|  .|.:  :.::....|.|.:..:|::...:|.|..|.:::....:    :|.|....:|||
  Rat  1061 CDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGE 1125

  Fly   722 NPCIYPTVGKSN---GVVRALTYCDIHKLHRDDLLDVLDSYPE 761
            ...:  .||..|   ..|.|..:.::..|.:.||.::|..|||
  Rat  1126 ISLL--AVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	49/235 (21%)
		Ion_trans_2	<526..580	CDD:285168	12/53 (23%)
		CAP_ED	657..767	CDD:237999	28/116 (24%)
		Crp	666..>766	CDD:223736	25/107 (23%)
Cngb1	NP_113997.2	PLN03192	743..>1129	CDD:215625	93/461 (20%)
Cngb1	NP_113997.2	CAP_ED	1057..1166	CDD:237999	26/114 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840