DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and KT5

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_194976.1	Gene:	KT5 / 829385	AraportID:	AT4G32500	Length:	880	Species:	Arabidopsis thaliana

Alignment Length:	540	Identity:	123/540 - (22%)
Similarity:	239/540 - (44%)	Gaps:	73/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 KNLKYNQAEKPTDNVMGNSYD---DMLDKEALLGSKSEPKGQDPNDMITSLGGNILLDQKLQNNY 307
            |.:.:...||....|:..:.|   :.:.:|..:...|..||     ::..||    :....:::.
plant     7 KKMVWFWPEKHEGGVIKEAEDVAAEHISREGTMSHYSFSKG-----LLPPLG----VGATARSSR 62

  Fly   308 YHKWTLLHYSPFK---AVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDL 369
            :.|......|||.   ..|||.::|||:|||..:|:...||...:            .|:.|:|.
plant    63 HIKLRCFIVSPFDPRYRAWDWFLVILVLYTAWASPFEFGFLQTPR------------APLSILDN 115

  Fly   370 IVDVTFIVDIIINFRTTFVNSQDE-VVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETT 433
            :|:..|.|||::.|...|::.... :|..|.|||..|.|.|.:.|:|:.||::|.  ||....|.
plant   116 VVNGFFAVDIVLTFFVAFLDKATYLLVDDPKRIAWRYTSTWLIFDVVSTVPYELF--GSLLHNTI 178

  Fly   434 TLIGLLKTARLLRLVRVAR---KIDRYSEYG----AAVLILLMATFILIAHWLACIWYAIG---- 487
            ...|:....||.||.||::   ::::..:|.    ....:||::.|::  |..||..|:|.
plant   179 QGYGIFSMLRLWRLHRVSKCFARLEKDRKYNYFWIRCTKLLLVSLFVV--HCGACFCYSIAAHYP 241

  Fly   488 -NAEKSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDA 551
             .:...:|.....|...                 |:..||:||:|::.|:.::.|:|::..|...
plant   242 DPSMTFMALAEANWKQK-----------------SLLIRYVTAMYWSITTFSTTGYGDIHGNNAE 289

  Fly   552 EKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYF 616
            |:||.:..|:....:.|.|.||::.::..:.|.|..:...:.....|.:.:.:|..|::::..:.
plant   290 ERAFILFYMIFNLGLLAYIIGNMTNLVVHVTSRTRNFRDTIQAASAFAQRNNLPLGLQEQMVAHL 354

  Fly   617 QHAW-TYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPP 680
            ...: |.:.|:....::...|:.:::.|..:|..:::.....|...|...|.....:.|..:.||
plant   355 SLRYRTDSEGLQQQEIIDSLPKAIRSSISHYLFYEVVDKTYLFHGISNDLLFQLVSEMKAEYFPP 419

  Fly   681 GDILVHRGDVLTSLYFIARGSIEIQRAGNIV--VLGK---NDIFGENP--CIYPTVGKSNGVVRA 738
            .:.::.|.:..:..|.:..|:::|....|.|  |:|:   ..:|||..  |..|.:    ..||.
plant   420 KEDVILRNEAPSDFYIMVTGAVDIIARVNGVDQVVGEAQTGHVFGEVGVLCYRPQL----FTVRT 480

  Fly   739 LTYCDIHKLHRDDLLDVLDS 758
            .....:.:|:|...|:::.:
plant   481 KRLSQLLRLNRTAFLNLVQA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	62/235 (26%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	24/109 (22%)
		Crp	666..>766	CDD:223736	22/100 (22%)
KT5	NP_194976.1	PLN03192	34..877	CDD:215625	118/513 (23%)
		ANK repeat	546..572	CDD:293786
		ANK repeat	574..605	CDD:293786
		ANK repeat	607..669	CDD:293786
		ANK repeat	671..702	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I2073
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1888
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	1	0.900	-	-		OOG6_100845
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760