DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Kcnh1

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_017454422.1	Gene:	Kcnh1 / 65198	RGDID:	68398	Length:	989	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	281/823 - (34%)
Similarity:	415/823 - (50%)	Gaps:	146/823 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 AGGKSKERPGTKITADCFFSPLLFKINNKRECLKKVKPMKGENAVETNGIPLESKPSQHKKQKSF 192
            |||    |.|.....:.|...::.:.|:....|...:.:........:|.   .|.|.:.:.:..
  Rat     4 AGG----RRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGF---CKLSGYHRAEVM 61

  Fly   193 KKCIKC-------------DKKKLYIKNYQVSARRECDLLCSYDPL--RKNNADLF--------- 233
            :|...|             :|.:...:||:::         |::.|  :||...::
  Rat    62 QKSSACSFMYGELTDKDTVEKVRQTFENYEMN---------SFEILMYKKNRTPVWFFVKIAPIR 117

  Fly   234 -QTHKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSK--------SEPKGQDPND- 288
             :..|...:.|.|.::...:.....|:..|......|.: ||..|:        |..||::.:.
  Rat   118 NEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTR-ALTSSRGVLQQLAPSVQKGENVHKH 181

  Fly   289 ----MITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQ 349
                .:..||.:||...|.:........:|||..||..||||||||..||||..||..:|...:
  Rat   182 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQ- 245

  Fly   350 DYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDL 414
                      |:...:::|.||||.|:|||::||.||||....||:|.|..|.::||..||:|||
  Rat   246 ----------NNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

  Fly   415 VAAVPFDLLLVGSDTDETTTLIG----------------------------LLKTARLLRLVRVA 451
            ::.:|:|::....:.||.:..:|                            .||..|||||.|||
  Rat   301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVA 365

  Fly   452 RKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAE------KSIASKNIGWLNSLAYDIQE 510
            ||:|.|.|||||||:||:..|.|.|||:|||||:||:.|      |:|  :|..||..||.||..
  Rat   366 RKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTI--RNNSWLYQLALDIGT 428

  Fly   511 PYFDNRT------GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYAS 569
            ||..|.:      ||||..|.||::||||.||||||||||:||:||.||.|.:.:|::|||:||:
  Rat   429 PYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 493

  Fly   570 IFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKG 634
            |||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:|:.:|....|:.:.|||...:|:.
  Rat   494 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQI 558

  Fly   635 FPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIAR 699
            .|:.::||||:|||||:.....||..||.|||||.:::|:|.|..|||::.|.|:.:.||.|:..
  Rat   559 CPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVS 623

  Fly   700 GSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFL 763
            ||:|:.:...:| :|||.|:||:......|:.:|...||||||||:|.:.||.|..||:.|..|.
  Rat   624 GSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688

  Fly   764 ESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSS---------------PDIPSIRIVGL 813
            .||..||::|||:|          .|.:..|.||..|..               ||.| :|.:..
  Rat   689 HSFSRNLILTYNLR----------KRIVFRKISDVKREEEERMKRKNEAPLILPPDHP-VRRLFQ 742

  Fly   814 RYKKQNVNTSVHKVKNDNSRDL--------NIFIENEIANYHL 848
            |:::|.   ..........|||        |...::..||:.|
  Rat   743 RFRQQK---EARLAAERGGRDLDDLDVEKGNALTDHTSANHSL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	122/262 (47%)
		Ion_trans_2	<526..580	CDD:285168	35/53 (66%)
		CAP_ED	657..767	CDD:237999	49/110 (45%)
		Crp	666..>766	CDD:223736	42/100 (42%)
Kcnh1	XP_017454422.1	PAS_9	39..135	CDD:290162	15/107 (14%)
		PAS	39..133	CDD:238075	15/105 (14%)
		Ion_trans	235..510	CDD:278921	126/287 (44%)
		Ion_trans_2	<450..504	CDD:285168	35/53 (66%)
		Crp	575..>720	CDD:223736	61/154 (40%)
		CAP_ED	581..691	CDD:237999	48/109 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920