Protein Alignment sei and HCN2

DIOPT Version :9

• Sequence 1: NP_001286814.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001185.3
• Gene: HCN2 / 610
• HGNCID: 4846
• Length: 889
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 142/563 - (25%)
• Similarity: 249/563 - (44%)
• Gaps: 84/563 - (14%)

  Fly   276 GSKSEPKGQDPNDMITSLGG-----------NILLDQKLQNNYYHK------WTLLHYSPFKAVW 323
            |...||:|...:.|....|.           .:...||.......:      |.:..||.|:..|
Human   150 GPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYW 214

  Fly   324 DWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFV 388
            |:.:|:.::...|..|....|...|           .:.|.::.:::.|..|::|:::||||..|
Human   215 DFTMLLFMVGNLIIIPVGITFFKDE-----------TTAPWIVFNVVSDTFFLMDLVLNFRTGIV 268

  Fly   389 -NSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV----GSDTDETTTLIGL--------LK 440
             ....|::..|.:|...||..||::|.|:::|.|.:.:    |.|::...|...|        |.
Human   269 IEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILS 333

  Fly   441 TARLLRLVRVARKIDRYSE-----YGAAVLIL----LMATFILIAHWLACIWYAIGNAEKSIASK 496
            ..|||||.|:.|.|.::.|     |..|..::    |::..:|:.||..|:.:.:...:.  ..:
Human   334 LLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQD--FPR 396

  Fly   497 NIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVML 561
            |. |::.           |.....|....|..||:...:.:..:|:|..||.:..:...|:..|:
Human   397 NC-WVSI-----------NGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMI 449

  Fly   562 VGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNG- 625
            ||:..||...|:.:|:||.|.|...:|..:..:|.:::.||::|...||::.:|::|.:   .|
Human   450 VGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY---QGK 511

  Fly   626 -IDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGD 689
             .|.:|:|......|:.:|.....|||:.:...|:.|.|..:.|...|.|.....|||.::..|.
Human   512 MFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGT 576

  Fly   690 VLTSLYFIARGSIEIQRAGN-IVVLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLL 753
            :...:|||..|.:.:...|| .:.|.....||| .|:. |.|:....|||.|||.::.|..|:..
Human   577 IGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGE-ICLL-TRGRRTASVRADTYCRLYSLSVDNFN 639

  Fly   754 DVLDSYPEFLESFVS------------NLVITYNMRDDEHSGV 784
            :||:.||....:|.:            |.::.:.::.|.:|||
Human   640 EVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGV 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	63/244 (26%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	35/110 (32%)
		Crp	666..>766	CDD:223736	32/100 (32%)
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..159		4/8 (50%)
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		6/50 (12%)
		Ion_trans_N	167..209	CDD:285597	5/41 (12%)
		Ion_trans	229..474	CDD:278921	67/269 (25%)
		Crp	538..>673	CDD:223736	38/136 (28%)
		CAP_ED	544..652	CDD:237999	35/109 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..889

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810