DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sei and kcnh6b

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_021328182.1	Gene:	kcnh6b / 570070	ZFINID:	ZDB-GENE-121214-55	Length:	893	Species:	Danio rerio

Alignment Length:	542	Identity:	337/542 - (62%)
Similarity:	421/542 - (77%)	Gaps:	14/542 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 LLGSKSEPKGQDPNDMIT---SLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTA 335
            |:..|.:.:.|:..:.:|   |||.::|.:.|||....|||.:||||||||:|||:||:||:|||
Zfish    52 LVTPKVKERTQNVTEKVTQVLSLGADVLPEYKLQAPDVHKWIMLHYSPFKAIWDWVILLLVLYTA 116

  Fly   336 IFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGR 400
            :|||:.|||||.|.:.:||.:.....:|:.::|:||||.||.||:|.||||:||..||||:||.|
Zfish   117 VFTPFSAAFLLNELEDERRQTCGYTCNPLNVVDVIVDVLFIADIVITFRTTYVNHNDEVVTHPKR 181

  Fly   401 IAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETT-TLIGLLKTARLLRLVRVARKIDRYSEYGAAV 464
            ||:||:.|||.||:|||:|||||:..|.:|||| ||||||||||||||||||||:||||||||||
Zfish   182 IAIHYIKGWFFIDMVAAIPFDLLIFRSGSDETTATLIGLLKTARLLRLVRVARKLDRYSEYGAAV 246

  Fly   465 LILLMATFILIAHWLACIWYAIGNAEKSIASKNIGWLNSLAYDIQEPYFD-NRTGGPSIKSRYIT 528
            |.|||.||.||||||||||||||:.|:..  ...|||::||..:.:.|.| :.:.||||:.:|||
Zfish   247 LFLLMCTFGLIAHWLACIWYAIGHVERPY--MKTGWLDNLADQLGKRYNDSDASSGPSIQDKYIT 309

  Fly   529 ALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQML 593
            ||||||:||||||||||:|||::||.|:||||.:|||||||||||||||||||||||.|||||||
Zfish   310 ALYFTFSSLTSVGFGNVSPNTNSEKMFSICVMFIGSLMYASIFGNVSAIIQRLYSGTTRYHTQML 374

  Fly   594 RVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAF 658
            ||:|||||||||..|||||||||||||:||||||||::||||||||||||||||||.||..|..|
Zfish   375 RVKEFIRFHQIPGGLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQNCKVF 439

  Fly   659 SEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV--VLGKNDIFGE 721
            ..||..||||.:::|::||:||||.|.|:||:|.:|:||:||||::.: .|||  :|||||:|||
Zfish   440 RGASKACLRALAVRFRSTHSPPGDALYHQGDMLRALHFISRGSIQVSQ-HNIVLAILGKNDVFGE 503

  Fly   722 NPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDDEH----S 782
            ...:|...|.||..|.||||||:|::.|||||:|||.||.|.|||..||.||:|:||.|.    .
Zfish   504 PVNLYAEPGHSNADVTALTYCDLHRIRRDDLLEVLDMYPAFGESFWRNLEITFNLRDVEQMMPSE 568

  Fly   783 GVDIKHRYLRAKSSDKMRSSPD 804
            .::..::....::....|:.||
Zfish   569 SLECSYQARHRQNLLDRRNRPD 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	156/224 (70%)
		Ion_trans_2	<526..580	CDD:285168	45/53 (85%)
		CAP_ED	657..767	CDD:237999	62/111 (56%)
		Crp	666..>766	CDD:223736	57/101 (56%)
kcnh6b	XP_021328182.1	Ion_trans	103..364	CDD:306908	177/262 (68%)
		CAP_ED	438..549	CDD:237999	62/111 (56%)
		PAT1	<681..>831	CDD:330585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	381	1.000	Domainoid score	I794
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910