DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and cngb1a

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_696619.6	Gene:	cngb1a / 568211	ZFINID:	ZDB-GENE-050419-164	Length:	1326	Species:	Danio rerio

Alignment Length:	717	Identity:	145/717 - (20%)
Similarity:	258/717 - (35%)	Gaps:	186/717 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 KKQVFVSDILINASMFDDKKESLARFPKNVSDHNTLVYHKFLRTRPTNDDEALKLKAGGKSKERP 136
            |..|..||:|       :..|.|.| |.:.:...::|.|:.|:       |.:|
Zfish   618 KMDVNKSDLL-------NVDEGLER-PMSAASQTSIVVHERLQ-------ELVK----------- 656

  Fly   137 GTKITADCFFSPLLFKINNKRECLKKVKPMKGEN-------AVETNGIPLESKPSQHKKQKSFKK 194
                         |||...:|...|.|.|.:.::       |.:....|....|.:.||:...|
Zfish   657 -------------LFKGRTERRRDKLVDPDESDDESPSASPAKKPGEAPPPPPPPEQKKEAEEK- 707

  Fly   195 CIKCDKKKLYIKNYQVSARRECDLLCSYDPLRKNNADLFQTHKGTSYECMFKNLKYNQAEKPTDN 259
                                         |:.:...:: |.::...|:......|..|..:....
Zfish   708 -----------------------------PVEEEEEEV-QIYEFMGYKIPVPQFKIPQMPEWLRA 742

  Fly   260 VMGNSYDDMLDKEALLGSKSEPKGQDP-NDMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVW 323
            ::...:               |...|| .|:|                 |..|  |.:..|  .|
Zfish   743 ILAYRF---------------PSSIDPYTDLI-----------------YVVW--LFFVTF--AW 771

  Fly   324 DWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPI---VIIDLIVDVTFIVDI-IINFR 384
            :|.:.::        |....|            .|...|.|   :::|...|..:|:|| ::..|
Zfish   772 NWNVWLI--------PVRCTF------------PYQTPDNIHWWLLMDYFCDSIYIMDIFVVQPR 816

  Fly   385 TTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVR 449
            ..||...|.|.........:..:..|.:|:::..|.|:|.|      .|.:..||:..|||:...
Zfish   817 LQFVRGGDIVCDKNDMRENYRQTERFKMDVISLFPLDVLYV------FTGVKSLLRFPRLLKYNA 875

  Fly   450 VARKIDRYSEYGAAVLI---LLMATFILIA-HWLACIWYAIGNAEKSIASKNIGWLNSLAYDIQE 510
            .....||...:.:...|   :..:.::|.: |..|||:| .|:..:.:.|..  |:.
Zfish   876 FFEFNDRLEAWMSKAYIYRVIRTSAYLLYSLHCNACIFY-WGSDYEGLGSTK--WVY-------- 929

  Fly   511 PYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVS 575
                |..|     :.||...||...:|.::| |...|.|..|..|.:....||...::.:.|.:.
Zfish   930 ----NGKG-----NSYIRCYYFAVKTLITIG-GLPDPTTVFEIVFQLVNYFVGVFAFSIMIGQMR 984

  Fly   576 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQ 640
            .:|....:|.|.|...:....:::..::||..::.|::.::.:.|.....:|...||...|:.::
Zfish   985 DVIGAATAGEAYYRHSVDSTVKYMTSYRIPRDVQNRIKTWYDYTWKSQGMLDEQELLIQLPDKMR 1049

  Fly   641 ADICLHLNRKLLTTCAAFSEASPGCLR--AFSL--KFKTTHAPPGDILVHRGDVLTSLYFIARGS 701
            .||...:|..:::..|.|.    ||.|  .|.:  :.|:....|||.:..:|::...:|.|..|
Zfish  1050 LDIAADVNYSIVSKVALFQ----GCDRQMIFDMLKRLKSVVYLPGDFVCEKGEIGREMYIIKAG- 1109

  Fly   702 IEIQRAGN------IVVLGKNDIFGENPCIYPTVG-KSNGVVRALTYCDIHKLHRDDLLDVLDSY 759
             |:|..|.      .|.|....:|||...:....| :....|:|..:.::..|.:.||.::|..|
Zfish  1110 -EVQVVGGPDGKTVFVTLRAGSVFGEISLLAGGGGNRRTANVKAHGFANLFILDKKDLAEILVHY 1173

  Fly   760 PE 761
            ||
Zfish  1174 PE 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	53/230 (23%)
		Ion_trans_2	<526..580	CDD:285168	15/53 (28%)
		CAP_ED	657..767	CDD:237999	31/116 (27%)
		Crp	666..>766	CDD:223736	28/107 (26%)
cngb1a	XP_696619.6	ATP-synt_B	<384..450	CDD:304375
		Ion_trans	780..992	CDD:278921	55/250 (22%)
		Crp	1060..>1188	CDD:223736	32/122 (26%)
		CAP_ED	1066..1175	CDD:237999	29/114 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840