DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and cnga4

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_002663442.3	Gene:	cnga4 / 568123	ZFINID:	ZDB-GENE-070912-292	Length:	648	Species:	Danio rerio

Alignment Length:	543	Identity:	130/543 - (23%)
Similarity:	223/543 - (41%)	Gaps:	114/543 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 NSYDDMLDKEALLGSKSEPKGQ---------------------DPNDMITSLGGNILLDQKLQNN 306
            |.:..:.:::.:..::.|.|||                     ||::                 .
Zfish     4 NRWTRLFERQRMNKNEEESKGQESTLKKKKDETPKTNWKEWVIDPSE-----------------E 51

  Fly   307 YYHKWTLLHYSPFKAVWDWIILI--LVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDL 369
            :|:.|..:...|.  .::|:|:|  ...|| |...|||.:|                    .:|.
Zfish    52 FYYTWLQIMTLPI--CYNWVIIICRTCFYT-IEEAYVATWL--------------------TLDY 93

  Fly   370 IVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYL-SGWFLIDLVAAVPFDLLL--VGSDTDE 431
            :.|:.:::|.||.|||.|: .|..:|....|:...|| |..|..|:.:.:|.|||.  :|..|.
Zfish    94 LCDLVYVLDTIIGFRTGFL-EQGILVRDLSRLKTRYLRSSRFKWDMTSLLPTDLLYLQLGIHTP- 156

  Fly   432 TTTLIGLLKTARLLRLVRVARKIDRY-------SEYGAAVLILLMATFILIAHWLACIWYAIGNA 489
                  |::..|.||..|:...:||.       :.:..|.|:|.:  |:|| ||.|||::::.|
Zfish   157 ------LVRVNRFLRTGRLNEALDRMETRTSFPNAFRVAKLMLYI--FVLI-HWNACIYFSLSN- 211

  Fly   490 EKSIASKNIG-----WLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNT 549
                   .||     |:..   :|..|.|      .|::.:|....:|:...||:|| ....|..
Zfish   212 -------YIGFGADPWVYP---NISHPEF------ASMRRQYFYCFWFSTLILTTVG-DTPTPER 259

  Fly   550 DAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEE 614
            :.|..|.|..||:..|::||:.|::..:|..|......:......|:.::|.|:|...|::|:.:
Zfish   260 EEEYMFLIADMLIAVLVFASVVGSMGDVISSLRDRDNVFFPDHELVKGYLRSHRISKELQKRVND 324

  Fly   615 YFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAP 679
            ::||..........|.:|:..|..||....:.::...|:....|.......|....||.......
Zfish   325 WYQHLHINKKITRENEILQHLPMTLQTATAVSVHLPTLSKVTIFQNCENSLLEQLVLKLTPQVYS 389

  Fly   680 PGDILVHRGDVLTSLYFIARGSIEIQRAGNI---VVLGKNDIFGENPCIYPTVGKS----NGVVR 737
            ||:.:..:|||...:|.|..|.:.:.....:   .|||..:.|||...:.....||    ...:|
Zfish   390 PGEYVCKKGDVGHEMYIIKEGKLAVVADDGVTQFAVLGDGNFFGEISILNIKGNKSGNRRTANIR 454

  Fly   738 ALTYCDIHKLHRDDLLDVLDSYP 760
            ::.|.|:..|.::||.:.|..||
Zfish   455 SIGYSDLFSLSKEDLTETLLEYP 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	67/237 (28%)
		Ion_trans_2	<526..580	CDD:285168	17/53 (32%)
		CAP_ED	657..767	CDD:237999	29/111 (26%)
		Crp	666..>766	CDD:223736	28/102 (27%)
cnga4	XP_002663442.3	Ion_trans	77..294	CDD:278921	74/266 (28%)
		Crp	361..>497	CDD:223736	30/117 (26%)
		CAP_ED	367..483	CDD:237999	29/111 (26%)
		CLZ	483..552	CDD:293134
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840