DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and hcn3

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_689197.1	Gene:	hcn3 / 560709	ZFINID:	ZDB-GENE-060503-193	Length:	639	Species:	Danio rerio

Alignment Length:	512	Identity:	128/512 - (25%)
Similarity:	232/512 - (45%)	Gaps:	71/512 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 WTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTF 375
            |.:..||.|:..||.::|.|:|...:..|:...|...:           |:.|.:..::..|..|
Zfish   159 WIIHPYSDFRFYWDLVMLCLMMGNLVILPWGITFFEDQ-----------NTLPWITFNVASDTLF 212

  Fly   376 IVDIIINFRTTFVNSQD-EVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLL 439
            :.|::.||||..:...: |::..|..|:..||.||||:|.::::|.|.:.:..|.:.......:.
Zfish   213 LADLVFNFRTGIMEGDNSEIILDPQIISRRYLRGWFLVDFISSIPVDYIFLIVDIESRLESAEVY 277

  Fly   440 KTA---------------RLLRLVRVARKIDRYSE-------YGAAV--LILLMATFILIAHWLA 480
            :||               |||||.|:.|.|.::.|       ..:||  ::.|:...:|:.||..
Zfish   278 RTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDG 342

  Fly   481 CIWYAIGNAE----KSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVG 541
            |:.:.:...:    ....||| ..:|| .:|:|..|                ||:...:.:..:|
Zfish   343 CMQFMVPMLQDFPSTCWVSKN-NMVNS-TWDVQYSY----------------ALFMAMSHMLCIG 389

  Fly   542 FGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 606
            :|..||....:...|:..|::|:..||...||.:.::|.|.:...:|..:..:|.:::.||::|.
Zfish   390 YGAQAPEGPTDVWLTMISMIIGATCYAMFLGNATNLVQSLDASHRQYQEKYKQVEQYMSFHKLPA 454

  Fly   607 PLRQRLEEYFQHAWTYTNG--IDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAF 669
            .:|||:.:|::|.:   .|  .|..::|:...:.|:.:|..:..|.|:.....|:.|.|..:...
Zfish   455 DMRQRIHDYYEHRF---QGKMFDEENILEELSDPLKEEIVNYNCRGLVANMPLFANADPHFVTVL 516

  Fly   670 SLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGN-IVVLGKNDIFGENPCIYPTVGKSN 733
            ..|.:.....|||:::..|.:...:|||..|.:.:..:.| ...|.....||| .|:. |.|:..
Zfish   517 LSKLRFEVFQPGDVIIREGTLGRKMYFIQHGCVSVITSDNKEKKLNDGCYFGE-ICLL-TRGRRT 579

  Fly   734 GVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDDEHSGVDIKHRY 790
            ..|||.|||.::.|..|...:||:..|....:|.:   :..|....|.:|.:  |.|
Zfish   580 ASVRADTYCRLYSLSVDSFNEVLEENPLMRRAFEN---VAVNRLGRESNGYE--HSY 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	63/251 (25%)
		Ion_trans_2	<526..580	CDD:285168	13/53 (25%)
		CAP_ED	657..767	CDD:237999	31/110 (28%)
		Crp	666..>766	CDD:223736	28/100 (28%)
hcn3	XP_689197.1	Ion_trans_N	124..166	CDD:285597	2/6 (33%)
		Ion_trans	186..429	CDD:278921	64/271 (24%)
		Ion_trans_2	<377..427	CDD:285168	13/49 (27%)
		Crp	498..>622	CDD:223736	34/128 (27%)
		CAP_ED	504..612	CDD:237999	31/109 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840