DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and kcnh1a

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_009291371.1	Gene:	kcnh1a / 560568	ZFINID:	ZDB-GENE-061226-1	Length:	977	Species:	Danio rerio

Alignment Length:	699	Identity:	262/699 - (37%)
Similarity:	391/699 - (55%)	Gaps:	78/699 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 DKKKLYIKNYQVSARRECDLLCSYDPL--RKNNADLF----------QTHKGTSYECMFKNLKYN 251
            :|.:|..:||:::         |::.|  :||...::          :..|...:.|.|.::...
Zfish    88 EKVRLTFENYEMN---------SFEILMYKKNRTPVWFFVKIAPIRNEQEKVVLFLCTFSDITAF 143

  Fly   252 QAEKPTDNVMGNSYDDMLDKEALLGSKS-----EP---KGQDPND-----MITSLGGNILLDQKL 303
            :.....|:..|......|.: ||..|:.     :|   ||::.:.     .:..||.:||...|.
Zfish   144 KQPIEDDSSKGWGKFARLTR-ALTSSRGVLQQLQPTVHKGENVHKHSRLAEVLQLGSDILPQYKQ 207

  Fly   304 QNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIID 368
            :........:|||..||..|||:||||..||||..||..:|...:           |:...:::|
Zfish   208 ETPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ-----------NNVTWLVVD 261

  Fly   369 LIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDET- 432
            .||||.|:|||::||.||||....||:|.|..|.::||..||:|||::.:|:|::....:.||.
Zfish   262 SIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDENW 326

  Fly   433 ---------TTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGN 488
                     ::|...||..|||||.|||||:|.|.|||||||:||:..|.|.|||||||||:||:
Zfish   327 NHRAVTQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWLACIWYSIGD 391

  Fly   489 AEKSIASKNI----GWLNSLAYDIQEPYFDNRT------GGPSIKSRYITALYFTFTSLTSVGFG 543
            .|.....:|.    .||..||..|..||..|.:      |||:..:.|||:||||.|||||:|||
Zfish   392 YEVIDEDRNTVRTDSWLYMLAESIGTPYRFNASGTGRWEGGPTKDTVYITSLYFTMTSLTSIGFG 456

  Fly   544 NVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPL 608
            |:||.||.||.|.:.:|::|||:||:|||||:.|.|::|:.|.|||..:..||:|::.:|:|..|
Zfish   457 NIAPTTDGEKIFAVAMMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGL 521

  Fly   609 RQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKF 673
            .:|:.:|....|:.::|||...:|:..|:.::||||:|||||:.....||..||.|||||.:::|
Zfish   522 SERVMDYIASTWSMSHGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEF 586

  Fly   674 KTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVR 737
            :|.|..|||::.|.|:.:.||.|:..||:|:.:...:| :|||.|:||:......|:.::...||
Zfish   587 QTIHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEVTLAQACANVR 651

  Fly   738 ALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDD--EHSGVDIK---HRYLRAKSSD 797
            ||||||:|.:.||.|..||:.|..|...|..||::|||:|..  .....|:|   ...||.|:..
Zfish   652 ALTYCDLHVIKRDALQKVLEFYTAFSNHFSRNLLLTYNLRKRLVFRKISDVKREEEERLRRKNEA 716

  Fly   798 KMRSSPDIPSIRIVGLRYKKQNVNTSVHKVKNDNSRDLNI---FIENEI 843
            .:...||.| :|.:..|:::|. ...:..|: .||.|.::   .|.||:
Zfish   717 PLNLPPDHP-VRRLFQRFRQQK-EARLAAVR-PNSEDSDLEKGQIHNEV 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	118/242 (49%)
		Ion_trans_2	<526..580	CDD:285168	35/53 (66%)
		CAP_ED	657..767	CDD:237999	47/110 (43%)
		Crp	666..>766	CDD:223736	41/100 (41%)
kcnh1a	XP_009291371.1	PAS_9	46..142	CDD:290162	11/62 (18%)
		PAS	46..140	CDD:238075	11/60 (18%)
		Ion_trans	242..499	CDD:278921	122/267 (46%)
		Ion_trans_2	<439..493	CDD:285168	35/53 (66%)
		Crp	564..>701	CDD:223736	54/136 (40%)
		CAP_ED	570..680	CDD:237999	47/109 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920