DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and kcnh7

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_021332696.1	Gene:	kcnh7 / 560289	ZFINID:	ZDB-GENE-120214-39	Length:	1177	Species:	Danio rerio

Alignment Length:	569	Identity:	351/569 - (61%)
Similarity:	438/569 - (76%)	Gaps:	14/569 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 KEALLGSKSEPKGQDPNDMIT---SLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVM 332
            ::.::..|.:.:..:..|.:|   |||.::|.:.|||....:|.|:||||||||||||:||:||:
Zfish   374 EKTIIAPKVKDRTHNVTDKVTQVLSLGADVLPEYKLQTPRINKLTILHYSPFKAVWDWLILLLVI 438

  Fly   333 YTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSH 397
            ||||||||.|||||.:.:.::|.....:..|:.::|||||:.|||||:||||||::|:.:|||||
Zfish   439 YTAIFTPYSAAFLLNDPEEEKRRECGYSCSPLNVVDLIVDIMFIVDILINFRTTYINANEEVVSH 503

  Fly   398 PGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSEYGA 462
            |.:|||||..|||.||:|||:|||||:....:||||||||||||||||||||||||:||||||||
Zfish   504 PAKIAVHYFKGWFFIDMVAAIPFDLLIFEGGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGA 568

  Fly   463 AVLILLMATFILIAHWLACIWYAIGNAEKSIASKNIGWLNSLAYDIQEPY-FDNRTGGPSIKSRY 526
            |||:|||..|.|||||||||||||||.|:......||||::|...|.:.| ..:...||||:.:|
Zfish   569 AVLMLLMCIFALIAHWLACIWYAIGNVERLYLDHTIGWLDNLGISIGKQYNISDDASGPSIRDKY 633

  Fly   527 ITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQ 591
            :|||||||:||||||||||:|||::||.|:|||||:|||||||||||||||||||||||||||.|
Zfish   634 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHLQ 698

  Fly   592 MLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMN-SLLKGFPECLQADICLHLNRKLLTTC 655
            ||||:||||||||||||||||||||||||||||||||| .:|||||||||||||||||:.||.:|
Zfish   699 MLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMEVLKGFPECLQADICLHLNKTLLQSC 763

  Fly   656 AAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIF 719
            .||..|:.|||||.:::||||||||||.|||.|||||:|||:|||||||.|...:| :|||||||
Zfish   764 KAFRGATKGCLRALAMRFKTTHAPPGDTLVHGGDVLTALYFLARGSIEILRDDIVVAILGKNDIF 828

  Fly   720 GENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDDEHSGV 784
            ||...:|...||:|..||||:|||:|.::|:|||:|||.||||.:.|:|||.:|:|:||:.....
Zfish   829 GEMIHLYAKPGKANADVRALSYCDLHTINREDLLEVLDMYPEFSDYFLSNLELTFNLRDENSKDT 893

  Fly   785 DIKHRYLRAKSSDKMRSSPDIPSIRIVGLRYKKQNVNTSVHKVKNDNSR 833
            ....|.|....||.....||:        |.::::.::.:...::|..|
Zfish   894 TAPQRTLYTAVSDSDTEDPDV--------RKRRRSTDSPIRPSRSDRER 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	156/223 (70%)
		Ion_trans_2	<526..580	CDD:285168	45/53 (85%)
		CAP_ED	657..767	CDD:237999	70/110 (64%)
		Crp	666..>766	CDD:223736	65/100 (65%)
kcnh7	XP_021332696.1	PAS_9	29..129	CDD:315989
		Ion_trans	428..690	CDD:306908	178/261 (68%)
		CAP_ED	765..876	CDD:237999	70/110 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578316
Domainoid	1	1.000	381	1.000	Domainoid score	I794
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	594	1.000	Inparanoid score	I938
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm25474
orthoMCL	1	0.900	-	-		OOG6_100845
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5087
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.920