DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and hcn2b

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_685414.3	Gene:	hcn2b / 557285	ZFINID:	ZDB-GENE-030131-8228	Length:	979	Species:	Danio rerio

Alignment Length:	513	Identity:	138/513 - (26%)
Similarity:	240/513 - (46%)	Gaps:	71/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 WTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTF 375
            |.:..||.|:..||:.:|:.::...|..|....|...|           .:.|.:|.:::.|..|
Zfish   225 WIIHPYSDFRFYWDFTMLMFMVGNLIIIPVGITFFKEE-----------TTTPWIIFNVVSDTFF 278

  Fly   376 IVDIIINFRTTFV-NSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV----GSDTDETTTL 435
            ::|:::||||..| ....|::..|.:|...||..||::|.|:::|.|.:.:    |.|::...|.
Zfish   279 LMDLVLNFRTGIVYEDNTEIILDPEKIKKKYLKTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTA 343

  Fly   436 IGL--------LKTARLLRLVRVARKIDRYSE-------YGAAV--LILLMATFILIAHWLACIW 483
            ..|        |...|||||.|:.|.|.::.|       ..:||  :|.|:...:|:.||..|:.
Zfish   344 RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRIINLIGMMLLLCHWDGCLQ 408

  Fly   484 YAIGNAEKSIASKNIGW--LNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVA 546
            :.:...:...:.   .|  ||.:..|             |....|..||:...:.:..:|:|..|
Zfish   409 FLVPMLQDFPSD---CWVSLNKMVND-------------SWSELYSFALFKAMSHMLCIGYGRQA 457

  Fly   547 PNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQR 611
            |.:.::...|:..|:||:..||...|:.:|:||.|.|...:|..:..:|.:::.||::|...||:
Zfish   458 PESMSDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQK 522

  Fly   612 LEEYFQHAWTYTNG--IDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFK 674
            :.:|::|.:   .|  .|..|:|:...|.|:.:|.....|||:.:...|:.|.|..:.|...|.:
Zfish   523 IHDYYEHRY---QGKMFDEESILEELNEPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLR 584

  Fly   675 TTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNI-VVLGKNDIFGENPCIYPTVGKSNGVVRA 738
            .....|||.::..|.:...:|||..|.:.:...||| :.|.....||| .|:. |.|:....|||
Zfish   585 FEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNIGMKLSDGSYFGE-ICLL-TRGRRTASVRA 647

  Fly   739 LTYCDIHKLHRDDLLDVLDSYPEFLESFVS------------NLVITYNMRDDEHSGV 784
            .|||.::.|..|:..:||:.||....:|.:            |.::.:.::.|.:|||
Zfish   648 DTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILMHKVQHDLNSGV 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	66/246 (27%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	35/110 (32%)
		Crp	666..>766	CDD:223736	32/100 (32%)
hcn2b	XP_685414.3	Ion_trans_N	190..232	CDD:285597	2/6 (33%)
		Ion_trans	252..497	CDD:278921	70/271 (26%)
		Crp	561..>696	CDD:223736	38/136 (28%)
		CAP_ED	567..675	CDD:237999	35/109 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810