DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and kcnh5a

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001263209.1	Gene:	kcnh5a / 556304	ZFINID:	ZDB-GENE-061106-2	Length:	1093	Species:	Danio rerio

Alignment Length:	849	Identity:	278/849 - (32%)
Similarity:	412/849 - (48%)	Gaps:	179/849 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KRNCPAKSNKFVER------ELFSLMCNLNKIEKKQVFVSDILINASMFDD----KKESLARFP- 98
            ||...|..|.|:|.      |...|:.|...:|...|:.:|.....|.:..    :|.|...|.
Zfish     5 KRGLVAPQNTFLENVVRRSSENSFLLGNAQIVEWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMY 69

  Fly    99 KNVSDHNTLVYHKFLRTRPTNDDEALKLKAGGKSKERPGTKITADCFFSPLLFKINNKRECL-KK 162
            ..::|..|:.     :.|.|.|:                  ..::| |..||:|.|.....| .:
Zfish    70 GELTDKKTID-----KVRQTFDN------------------YESNC-FEVLLYKKNRTPVWLHMQ 110

  Fly   163 VKPMKGENAVETNGIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLLCSYDPLRK 227
            |.|::.||                            ||..|::..::       |:.....|:..
Zfish   111 VAPIRNEN----------------------------DKVVLFLCTFK-------DITVFKQPIED 140

  Fly   228 NNADLFQTHKGTSYECMFKNLKYNQAEKPTDNVMGN-------SYDDMLDKEALLGSKSEPKGQD 285
                  :|.:|.:        |:.:..:...|..|.       :..::..|.:.|....:
Zfish   141 ------ETTRGWT--------KFARLTRALTNSRGTVQQLTPMNKTEVSHKHSRLAEALQ----- 186

  Fly   286 PNDMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQD 350
                   ||.:||...|.:........:|||..||..|||:||||..||||..||..:|...:
Zfish   187 -------LGSDILPQYKQEAPKTPPHIILHYCTFKTTWDWVILILTFYTAIMVPYNVSFKTKQ-- 242

  Fly   351 YQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLV 415
                     |:...:::|.:|||.|:|||::||.||||....||:|.|..|.::||..||:|||:
Zfish   243 ---------NNLVWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 298

  Fly   416 AAVPFDLLLVGSDTDETT--------------------------------TLIGLLKTARLLRLV 448
            :.:|:|::....:.||.|                                :|...||..|||||.
Zfish   299 SCLPYDIINAFENVDEDTFVDSSAVGHLPSAGHSPRNATRAEDSVLPGLSSLFSSLKVVRLLRLG 363

  Fly   449 RVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGN----AEKSIASKNIGWLNSLAYDIQ 509
            |||||:|.|.|||||||:||:..|.|:|||||||||:||:    .|.:.:.|...||..||..|.
Zfish   364 RVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEATNSLKTDSWLYQLAISIG 428

  Fly   510 EPYFDNRT------GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYA 568
            .||..|.:      ||||..:.||::||||.||||::||||:||.||.||.|::.:|:||||:||
Zfish   429 TPYRYNASGSGHWEGGPSKHTLYISSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAMMMVGSLLYA 493

  Fly   569 SIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLK 633
            :|||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:|:.:|....|..|.|||...:|.
Zfish   494 TIFGNVTTIFQQMYTNTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWAMTKGIDTEKVLS 558

  Fly   634 GFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIA 698
            ..|:.::||||:||||::.....||..||.||||:.:::|:|||..|||::.|.|:.:.:|.|:.
Zfish   559 ICPKDMRADICVHLNRQVFNEHPAFRLASDGCLRSLAVEFQTTHCAPGDLIFHAGESVDTLCFVV 623

  Fly   699 RGSIE-IQRAGNIVVLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEF 762
            .||:| ||....|.:|||.|:||:......::..:...||||||||:|.:.||.||.||:.|..|
Zfish   624 SGSLEVIQDDEVIAILGKGDVFGDVFWKESSLAHACANVRALTYCDLHVIRRDALLKVLEFYTAF 688

  Fly   763 LESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSSPDIPSIRIVGLRYKKQNVNTSV--- 824
            ..||..||::|.|:|          .|.:..|.:|..:...:        .|::|..|..|:
Zfish   689 ANSFSRNLILTCNLR----------KRIVFRKIADVKKEEEE--------RRHQKNEVTLSIPVD 735

  Fly   825 HKVK 828
            |.|:
Zfish   736 HPVR 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	118/264 (45%)
		Ion_trans_2	<526..580	CDD:285168	34/53 (64%)
		CAP_ED	657..767	CDD:237999	49/110 (45%)
		Crp	666..>766	CDD:223736	42/100 (42%)
kcnh5a	NP_001263209.1	PAS	40..131	CDD:238075	25/149 (17%)
		PAS_3	40..127	CDD:285623	25/138 (18%)
		Ion_trans	232..511	CDD:278921	122/289 (42%)
		Ion_trans_2	<451..505	CDD:285168	34/53 (64%)
		Crp	576..>734	CDD:223736	62/175 (35%)
		CAP_ED	582..692	CDD:237999	48/109 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920