DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and CNGB3

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_061971.3	Gene:	CNGB3 / 54714	HGNCID:	2153	Length:	809	Species:	Homo sapiens

Alignment Length:	692	Identity:	144/692 - (20%)
Similarity:	259/692 - (37%)	Gaps:	139/692 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 LFKINNKRECLKKVKPMKGENAVETNGIPLE--SKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSA 212
            :||...|   :.||||:...|..|.:....|  |.||...:|.:.::..|.::|.|..|:..|::
Human     1 MFKSLTK---VNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPVTS 62

  Fly   213 RR--------------ECDLLCSYDPLRKNNADLFQTHKGTSYECMFKNLKYNQAEKPTDNVMGN 263
            ..              ..||..:.||  :|.|:...|..........|....:...||....:.|
Human    63 EEPHTNIQDKLSKKNSSGDLTTNPDP--QNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVIN 125

  Fly   264 SYDD---------------MLDKEALLGSKSEPKGQDPNDMITSLGGNILLDQKLQNNYYH---- 309
            .|.|               :..|:.:.|..|.|:........|::......|.|...:||.
Human   126 EYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWF 190

  Fly   310 ---KWTLLHY-------SPFKAVWD-----WIILILVMY--TAIFTPYVAAFLLGEQDYQRRNSK 357
               |..|..|       :...:..|     |::|:.:.|  ...|.|....|            .
Human   191 KVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVF------------P 243

  Fly   358 YINSDPI---VIIDLIVDVTFIVDII-INFRTTFVNSQDEVVSHPGRIAVHY-LSGWFLIDLVAA 417
            |..:|.|   :|.|:|.|:.::.|:: |..|..||...|.:|. ...:..|| .|..|.:|:.:.
Human   244 YQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVD-SNELRKHYRTSTKFQLDVASI 307

  Fly   418 VPFDL--LLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSEYG---------AAVLILLMAT 471
            :|||:  |..|.:.        :.:..|:|       |...:.|:.         |.:..::..|
Human   308 IPFDICYLFFGFNP--------MFRANRML-------KYTSFFEFNHHLESIMDKAYIYRVIRTT 357

  Fly   472 --FILIAHWLACIWYAIGNAEKSIASKNIG---WLNSLAYDIQEPYFDNRTGGPSIKSRYITALY 531
              .:.|.|..||::|...|.|      .||   |:    ||.:             .:.|:...|
Human   358 GYLLFILHINACVYYWASNYE------GIGTTRWV----YDGE-------------GNEYLRCYY 399

  Fly   532 FTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVR 596
            :...:|.::| |...|.|..|..|.:.....|..:::|:.|.:..:|....:....:...|....
Human   400 WAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTI 463

  Fly   597 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEA 661
            .::..:.||..:::|:..::::.|.....:|.:.|||..|..:|..:.:.:|..:::....|...
Human   464 AYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGC 528

  Fly   662 SPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGN------IVVLGKNDIFG 720
            ....:....|:.|:....|||.:..:|::...:|.|..|  |:|..|.      :|.|....:||
Human   529 DTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHG--EVQVLGGPDGTKVLVTLKAGSVFG 591

  Fly   721 ENPCIYPTVG-KSNGVVRALTYCDIHKLHRDDLLDVLDSYPE 761
            |...:....| :....|.|..:.::..|.:..|.::|..||:
Human   592 EISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPD 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	54/243 (22%)
		Ion_trans_2	<526..580	CDD:285168	13/53 (25%)
		CAP_ED	657..767	CDD:237999	26/112 (23%)
		Crp	666..>766	CDD:223736	25/103 (24%)
CNGB3	NP_061971.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		29/124 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..178		4/24 (17%)
		Ion_trans	238..453	CDD:278921	56/266 (21%)
		Crp	521..>648	CDD:223736	26/115 (23%)
		CAP_ED	524..639	CDD:237999	26/112 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840