DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and KCNH1

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_758872.1	Gene:	KCNH1 / 3756	HGNCID:	6250	Length:	989	Species:	Homo sapiens

Alignment Length:	823	Identity:	282/823 - (34%)
Similarity:	416/823 - (50%)	Gaps:	146/823 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 AGGKSKERPGTKITADCFFSPLLFKINNKRECLKKVKPMKGENAVETNGIPLESKPSQHKKQKSF 192
            |||    |.|.....:.|...::.:.|:....|...:.:........:|.   .|.|.:.:.:..
Human     4 AGG----RRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGF---CKLSGYHRAEVM 61

  Fly   193 KKCIKC-------------DKKKLYIKNYQVSARRECDLLCSYDPL--RKNNADLF--------- 233
            :|...|             :|.:...:||:::         |::.|  :||...::
Human    62 QKSSTCSFMYGELTDKDTIEKVRQTFENYEMN---------SFEILMYKKNRTPVWFFVKIAPIR 117

  Fly   234 -QTHKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSK--------SEPKGQDPND- 288
             :..|...:.|.|.::...:.....|:..|......|.: ||..|:        |..||::.:.
Human   118 NEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTR-ALTSSRGVLQQLAPSVQKGENVHKH 181

  Fly   289 ----MITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQ 349
                .:..||.:||...|.:........:|||..||..||||||||..||||..||..:|...:
Human   182 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQ- 245

  Fly   350 DYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDL 414
                      |:...:::|.||||.|:|||::||.||||....||:|.|..|.::||..||:|||
Human   246 ----------NNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

  Fly   415 VAAVPFDLLLVGSDTDETTTLIG----------------------------LLKTARLLRLVRVA 451
            ::.:|:|::....:.||.:..:|                            .||..|||||.|||
Human   301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVA 365

  Fly   452 RKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAE------KSIASKNIGWLNSLAYDIQE 510
            ||:|.|.|||||||:||:..|.|.|||:|||||:||:.|      |:|  :|..||..||.||..
Human   366 RKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTI--RNNSWLYQLAMDIGT 428

  Fly   511 PYFDNRT------GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYAS 569
            ||..|.:      ||||..|.||::||||.||||||||||:||:||.||.|.:.:|::|||:||:
Human   429 PYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 493

  Fly   570 IFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKG 634
            |||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:|:.:|....|:.:.|||...:|:.
Human   494 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQI 558

  Fly   635 FPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIAR 699
            .|:.::||||:|||||:.....||..||.|||||.:::|:|.|..|||::.|.|:.:.||.|:..
Human   559 CPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVS 623

  Fly   700 GSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFL 763
            ||:|:.:...:| :|||.|:||:......|:.:|...||||||||:|.:.||.|..||:.|..|.
Human   624 GSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688

  Fly   764 ESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSS---------------PDIPSIRIVGL 813
            .||..||::|||:|          .|.:..|.||..|..               ||.| :|.:..
Human   689 HSFSRNLILTYNLR----------KRIVFRKISDVKREEEERMKRKNEAPLILPPDHP-VRRLFQ 742

  Fly   814 RYKKQNVNTSVHKVKNDNSRDL--------NIFIENEIANYHL 848
            |:::|.   ..........|||        |:..|:..||:.|
Human   743 RFRQQK---EARLAAERGGRDLDDLDVEKGNVLTEHASANHSL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	122/262 (47%)
		Ion_trans_2	<526..580	CDD:285168	35/53 (66%)
		CAP_ED	657..767	CDD:237999	49/110 (45%)
		Crp	666..>766	CDD:223736	42/100 (42%)
KCNH1	NP_758872.1	PAS_9	41..135	CDD:379177	15/105 (14%)
		Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000269\|PubMed:27005320	151..162		3/11 (27%)
		PLN03192	220..>647	CDD:215625	195/439 (44%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q63472	463..468		4/4 (100%)
		PRK11753	608..>712	CDD:236969	43/113 (38%)
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:10880439	673..770		29/110 (26%)
		Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000250\|UniProtKB:Q60603	699..701		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..886
		CAD (involved in subunit assembly). /evidence=ECO:0000250\|UniProtKB:Q63472	924..964
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920