DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and CngB

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_611607.2	Gene:	CngB / 37479	FlyBaseID:	FBgn0266346	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	130/680 - (19%)
Similarity:	249/680 - (36%)	Gaps:	153/680 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 HKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPNDMITSLGGNILLD 300
            |:|..:|          |:.|..||...|        :|.|:.::.:..||
  Fly   431 HRGRLFE----------ADTPRSNVWLCS--------SLCGANNDERTLDP-------------- 463

  Fly   301 QKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIV 365
               |...|..|..            ::.:..:|.|...|..|:|     .:|.:.    |::..:
  Fly   464 ---QGKIYISWLC------------VVSLSFLYNAWVIPLRASF-----PFQTKE----NTNIWL 504

  Fly   366 IIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSG-WFLIDLVAAVPFDLLLVGSDT 429
            ..|...|:.:::|::..........:...|.:......:|:.. .|.:||:|.:|.:||.....|
  Fly   505 ACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGT 569

  Fly   430 DETTTLIGLLKTARLLRLV---RVARKIDRYSEYGAAVLILLMATFIL-IAHWLACIWYAIGNAE 490
            ...     .|:..|..::.   .|.|.:||.......|.:....|::| :.|..|.::||..:.:
  Fly   570 QAV-----WLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQ 629

  Fly   491 KSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAF 555
                  .:|         |..:..:..|.|     |:....|...:.||:| .|..|....|..|
  Fly   630 ------GLG---------QNRWVFSGKGHP-----YVRCFAFATKTATSIG-KNPKPERQGEYVF 673

  Fly   556 TICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAW 620
            .....|:|..::|.:.|.:..||.........|........|::|...:...::.|::.:||..|
  Fly   674 MTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTW 738

  Fly   621 TYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILV 685
            .....:|.:::|...|..|:.||.:.::.:.|:....|::.....||...||.:.....|||.:.
  Fly   739 EQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVC 803

  Fly   686 HRGDVLTSLYFIARGSIEIQRAGN----IVVLGKNDIFGENPCIYPTVGKSNGV------VRALT 740
            .:|:|...:|.:..|.:::....:    :..|.:..:|||...:     ..||.      ||:..
  Fly   804 RKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLL-----GINGADRRTADVRSKG 863

  Fly   741 YCDIHKLHRDDLLDVLDSYP---EFLESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSS 802
            |.::..|.:.||.:|:..||   ..|:.....|:.....|:.|..    :.|...|..:|.:..:
  Fly   864 YSNLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAAREREEE----RERARSALQADVVIGN 924

  Fly   803 P-------------------DIPSIRIV-----GLRYKKQNVN-----------TSVHKVKNDN- 831
            |                   :.|::.::     .:|.|:|:|.           |...:.::..
  Fly   925 PKTPETAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMETIVEPKMEVTGAAETQDQKG 989

  Fly   832 ------SRDLNIFIENEIANYH--LDLFDN 853
                  |.||...|:.|:.:.|  ::|.|:
  Fly   990 LKTGRCSPDLLSSIQQELKSKHKFINLTDS 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	46/227 (20%)
		Ion_trans_2	<526..580	CDD:285168	15/53 (28%)
		CAP_ED	657..767	CDD:237999	28/122 (23%)
		Crp	666..>766	CDD:223736	27/112 (24%)
CngB	NP_611607.2	Ion_trans	488..704	CDD:278921	49/250 (20%)
		DUF4105	<672..755	CDD:290123	16/82 (20%)
		Crp	769..>898	CDD:223736	30/133 (23%)
		CAP_ED	775..889	CDD:237999	27/118 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445373
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840