Protein Alignment sei and HCN1

DIOPT Version :9

• Sequence 1: NP_001286814.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_066550.2
• Gene: HCN1 / 348980
• HGNCID: 4845
• Length: 890
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 138/512 - (26%)
• Similarity: 239/512 - (46%)
• Gaps: 69/512 - (13%)

  Fly   311 WTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTF 375
            |.:..||.|:..||.|:||:::...:..|....|.. ||          .:.|.:|.::..|..|
Human   133 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFT-EQ----------TTTPWIIFNVASDTVF 186

  Fly   376 IVDIIINFRTTFVN-SQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV----GSDTDETTTL 435
            ::|:|:||||..|| ...|::..|..|.::||..||::|.::::|.|.:.:    |.|::...|.
Human   187 LLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTA 251

  Fly   436 IGL--------LKTARLLRLVRVARKIDRYSE-----YGAAVLIL----LMATFILIAHWLACIW 483
            ..|        |...|||||.|:.|.|.::.|     |..|..::    |:...:|:.||..|:.
Human   252 RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQ 316

  Fly   484 YAIGNAEKSIASKNIGW--LNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVA 546
            :.:...:.....   .|  ||.:..|             |...:|..||:...:.:..:|:|..|
Human   317 FLVPLLQDFPPD---CWVSLNEMVND-------------SWGKQYSYALFKAMSHMLCIGYGAQA 365

  Fly   547 PNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQR 611
            |.:.::...|:..|:||:..||...|:.:|:||.|.|...:|..:..:|.:::.||::|..:||:
Human   366 PVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQK 430

  Fly   612 LEEYFQHAWTYTNGI-DMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            :.:|::|  .|...| |..::|....:.|:.:|.....|||:.|...|:.|.|..:.|...|.:.
Human   431 IHDYYEH--RYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRF 493

  Fly   676 THAPPGDILVHRGDVLTSLYFIARG-SIEIQRAGNIVVLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            ....|||.::..|.|...:|||..| :..|.::...:.|.....||| .|:. |.|:....|||.
Human   494 EVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE-ICLL-TKGRRTASVRAD 556

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVS------------NLVITYNMRDDEHSGV 784
            |||.::.|..|:..:||:.||....:|.:            |.::....:.|.::||
Human   557 TYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGV 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	66/246 (27%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	34/110 (31%)
		Crp	666..>766	CDD:223736	31/100 (31%)
HCN1	NP_066550.2	Disordered. /evidence=ECO:0000305|PubMed:28086084	1..93
		Ion_trans_N	98..140	CDD:285597	2/6 (33%)
		Ion_trans	160..405	CDD:278921	71/271 (26%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28086084	358..362		1/3 (33%)
		Crp	469..>604	CDD:223736	38/136 (28%)
		CAP_ED	475..583	CDD:237999	34/109 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..692
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..796
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..890

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740