DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Kcnh3

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_058804.1	Gene:	Kcnh3 / 27150	RGDID:	71070	Length:	1087	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	224/553 - (40%)
Similarity:	314/553 - (56%)	Gaps:	81/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 KSEPK----------GQDPNDMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVM 332
            :.:||          |:.||          |.:.|:.......:.|||....:|.||..||:..:
  Rat   182 QKQPKGKHKLNKGVFGEKPN----------LPEYKVAAIRKSPFILLHCGALRATWDGFILLATL 236

  Fly   333 YTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSH 397
            |.|:..||........:....|.       |..:.||.|:|.||:||::|||||||:...:||..
  Rat   237 YVAVTVPYSVCVSTAREPSAARG-------PPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFA 294

  Fly   398 PGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIG--LLKTARLLRLVRVARKIDRYSEY 460
            |..|.:||::.|||:|::||:|||||    ...:....:|  ||||.|||||:|:..::||||:|
  Rat   295 PKSICLHYVTTWFLLDVIAALPFDLL----HAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQY 355

  Fly   461 GAAVLILLMATFILIAHWLACIWYAIG-----NAEKSIASKNIGWLNSLAYDIQEPYF------- 513
            .|.||.||||.|.|:|||:||:|:.||     |:|..:  ..||||..||..::.||:
  Rat   356 SAVVLTLLMAVFALLAHWVACVWFYIGQQEIENSESEL--PEIGWLQELARRLETPYYLVSRSPD 418

  Fly   514 -------------------DNRT-----GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKA 554
                               .|.|     ||||::|.|||:|||..:||||||||||:.|||.||.
  Rat   419 GGNSSGQSENCSSSGGGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKI 483

  Fly   555 FTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHA 619
            |:||.||:|:||:|.:||||:|||||:|:....||::...:|::||.|:||.||:||:.||||..
  Rat   484 FSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQAT 548

  Fly   620 WTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDIL 684
            |...||||...||:..|:.|:|||.:||::::| ....|..||.|||||.||..:.....||:.|
  Rat   549 WAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYL 612

  Fly   685 VHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYP---TVGKSNGVVRALTYCDIH 745
            :|:||.|.:|||:..||:|:.:.|.:: :|||.|:.|   |..|   .|.|:|..|:.||||.:.
  Rat   613 IHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIG---CELPQREQVVKANADVKGLTYCVLQ 674

  Fly   746 KLHRDDLLDVLDSYPEFLESFVSNL--VITYNM 776
            .|....|.:.|..||||...|...|  .::||:
  Rat   675 CLQLAGLHESLALYPEFAPRFSRGLRGELSYNL 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	122/260 (47%)
		Ion_trans_2	<526..580	CDD:285168	37/53 (70%)
		CAP_ED	657..767	CDD:237999	46/113 (41%)
		Crp	666..>766	CDD:223736	41/103 (40%)
Kcnh3	NP_058804.1	PAS	42..133	CDD:238075
		PAS_3	42..123	CDD:285623
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..161
		Ion_trans	246..514	CDD:278921	124/280 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..436		0/19 (0%)
		Ion_trans_2	<455..509	CDD:285168	37/53 (70%)
		Selectivity filter. /evidence=ECO:0000250	468..473		4/4 (100%)
		CAP_ED	585..695	CDD:237999	46/112 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	733..813
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	975..1061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840