DRSC/TRiP Functional Genomics Resources

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Protein Alignment sei and KCNH5

DIOPT Version :10

Sequence 1:NP_476713.1 Gene:sei / 37843 FlyBaseID:FBgn0003353 Length:855 Species:Drosophila melanogaster
Sequence 2:NP_647479.2 Gene:KCNH5 / 27133 HGNCID:6254 Length:988 Species:Homo sapiens


Alignment Length:685 Identity:259/685 - (37%)
Similarity:379/685 - (55%) Gaps:53/685 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 LESKPSQHKKQKSFKKC-IKCDKKKLYIKNYQVSARRECDLLCSYDPLRKNNADLFQTHKGTSYE 242
            |..|.:..|.:::|... ..|.:..||.||     |..........|:|..:      .|...:.
Human    72 LTDKKTIEKVRQTFDNYESNCFEVLLYKKN-----RTPVWFYMQIAPIRNEH------EKVVLFL 125

  Fly   243 CMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPNDM------------ITSLGG 295
            |.||::...:.....|:..|.:....|.: ||..|:|..:...|.:.            :..||.
Human   126 CTFKDITLFKQPIEDDSTKGWTKFARLTR-ALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGS 189

  Fly   296 NILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYIN 360
            :||...|.:........:|||..||..|||:||||..||||..||..:|...:           |
Human   190 DILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ-----------N 243

  Fly   361 SDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV 425
            :...:::|.:|||.|:|||::||.||||....||:|.|..|.::||..||:|||::.:|:|::..
Human   244 NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINA 308

  Fly   426 GSDTDE-TTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNA 489
            ..:.|| .::|...||..|||||.|||||:|.|.|||||||:||:..|.|:|||||||||:||:.
Human   309 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDY 373

  Fly   490 EKSIASKNI----GWLNSLAYDIQEPYFDNRT-----GGPSIKSRYITALYFTFTSLTSVGFGNV 545
            |......|.    .||..||..|..||..|.:     ||||..|.|:::||||.||||::||||:
Human   374 EVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNI 438

  Fly   546 APNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 610
            ||.||.||.|::.:|:||||:||:|||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:
Human   439 APTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

  Fly   611 RLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            |:.:|....|:.:.|||...:|...|:.::||||:|||||:.....||..||.|||||.:::|:|
Human   504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568

  Fly   676 THAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            .|..|||::.|.|:.:.:|.|:..||:|:.:...:| :|||.|:||:......|:..:...||||
Human   569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRAL 633

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDD--EHSGVDIK---HRYLRAKSSDKM 799
            ||||:|.:.|:.||.|||.|..|..||..||.:|.|:|..  .....|:|   ...||.|:...:
Human   634 TYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTL 698

  Fly   800 RSSPDIPSIRIVGLRYKKQNVNTSVHKVKNDNSRD 834
            ....|.| :|.:..::|:|....:....:.|..|:
Human   699 SIPVDHP-VRKLFQKFKQQKELRNQGSTQGDPERN 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
seiNP_476713.1 Ion_trans 322..583 CDD:459842 131/270 (49%)
CAP_ED 657..767 CDD:237999 48/110 (44%)
KCNH5NP_647479.2 PAS_9 39..132 CDD:463873 16/70 (23%)
PLN03192 217..>616 CDD:215625 188/409 (46%)
Selectivity filter. /evidence=ECO:0000250 432..437 2/4 (50%)
Crp 551..758 CDD:440428 65/183 (36%)
Calmodulin-binding. /evidence=ECO:0000255 704..715 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 717..742 2/16 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..890
CAD (involved in subunit assembly). /evidence=ECO:0000250 909..948
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 969..988
Blue background indicates that the domain is not in the aligned region.

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