DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and KCNH5

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_647479.2	Gene:	KCNH5 / 27133	HGNCID:	6254	Length:	988	Species:	Homo sapiens

Alignment Length:	685	Identity:	259/685 - (37%)
Similarity:	379/685 - (55%)	Gaps:	53/685 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LESKPSQHKKQKSFKKC-IKCDKKKLYIKNYQVSARRECDLLCSYDPLRKNNADLFQTHKGTSYE 242
            |..|.:..|.:::|... ..|.:..||.||     |..........|:|..:      .|...:.
Human    72 LTDKKTIEKVRQTFDNYESNCFEVLLYKKN-----RTPVWFYMQIAPIRNEH------EKVVLFL 125

  Fly   243 CMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPNDM------------ITSLGG 295
            |.||::...:.....|:..|.:....|.: ||..|:|..:...|.:.            :..||.
Human   126 CTFKDITLFKQPIEDDSTKGWTKFARLTR-ALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGS 189

  Fly   296 NILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYIN 360
            :||...|.:........:|||..||..|||:||||..||||..||..:|...:           |
Human   190 DILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ-----------N 243

  Fly   361 SDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV 425
            :...:::|.:|||.|:|||::||.||||....||:|.|..|.::||..||:|||::.:|:|::..
Human   244 NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINA 308

  Fly   426 GSDTDE-TTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNA 489
            ..:.|| .::|...||..|||||.|||||:|.|.|||||||:||:..|.|:|||||||||:||:.
Human   309 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDY 373

  Fly   490 EKSIASKNI----GWLNSLAYDIQEPYFDNRT-----GGPSIKSRYITALYFTFTSLTSVGFGNV 545
            |......|.    .||..||..|..||..|.:     ||||..|.|:::||||.||||::||||:
Human   374 EVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNI 438

  Fly   546 APNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 610
            ||.||.||.|::.:|:||||:||:|||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:
Human   439 APTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

  Fly   611 RLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            |:.:|....|:.:.|||...:|...|:.::||||:|||||:.....||..||.|||||.:::|:|
Human   504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568

  Fly   676 THAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            .|..|||::.|.|:.:.:|.|:..||:|:.:...:| :|||.|:||:......|:..:...||||
Human   569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRAL 633

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDD--EHSGVDIK---HRYLRAKSSDKM 799
            ||||:|.:.|:.||.|||.|..|..||..||.:|.|:|..  .....|:|   ...||.|:...:
Human   634 TYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTL 698

  Fly   800 RSSPDIPSIRIVGLRYKKQNVNTSVHKVKNDNSRD 834
            ....|.| :|.:..::|:|....:....:.|..|:
Human   699 SIPVDHP-VRKLFQKFKQQKELRNQGSTQGDPERN 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	117/232 (50%)
		Ion_trans_2	<526..580	CDD:285168	33/53 (62%)
		CAP_ED	657..767	CDD:237999	48/110 (44%)
		Crp	666..>766	CDD:223736	41/100 (41%)
KCNH5	NP_647479.2	PAS_9	39..132	CDD:404329	16/70 (23%)
		PLN03192	217..>616	CDD:215625	188/409 (46%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	544..725	CDD:223736	64/181 (35%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..742		2/16 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..890
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920