DRSC/TRiP Functional Genomics Resources

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Protein Alignment sei and Kcnh8

DIOPT Version :10

Sequence 1:NP_476713.1 Gene:sei / 37843 FlyBaseID:FBgn0003353 Length:855 Species:Drosophila melanogaster
Sequence 2:NP_659563.1 Gene:Kcnh8 / 246325 RGDID:2549 Length:1102 Species:Rattus norvegicus


Alignment Length:657 Identity:262/657 - (39%)
Similarity:385/657 - (58%) Gaps:60/657 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 KRECLKKVKPMKGENAVETN-GIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLL 219
            :.|.::|....|....|||| .:.|:.:.|..:|.: ||..|     ..|.||       .....
  Rat    57 RTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVE-FKGEI-----MFYKKN-------GAPFW 108

  Fly   220 CSYD--PLRKNNADLFQTHKGTSYECMFKNL-----KYNQAEKPTDNVMGNS-----YDD--MLD 270
            |..|  |::....|:      ..:...||::     |....:|..|...|.|     :|.  ...
  Rat   109 CLLDIVPIKNEKGDV------VLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRS 167

  Fly   271 KEALLGSKSEPKGQDPNDMITSLGGNILLDQ------KLQNNYYHKWTLLHYSPFKAVWDWIILI 329
            :..|.......:.::.|.:  .:..|:.:|:      |:.:....|:.|||:|.|||.|||:||:
  Rat   168 RAVLYHISGHLQRREKNKL--KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILL 230

  Fly   330 LVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEV 394
            ...|.|:..||...| :|.:|.....|..::       |:.|::.||:|||:|||||:|:...:|
  Rat   231 ATFYVAVTVPYNVCF-IGNEDLSTTRSTTVS-------DIAVEILFIIDIILNFRTTYVSKSGQV 287

  Fly   395 VSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSE 459
            :.....|.:||::.||:|||:||:|||||...:.|  ..:|:.||||.|||||:|:.:|:||||:
  Rat   288 IFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQ 350

  Fly   460 YGAAVLILLMATFILIAHWLACIWYAIGNAEK---SIASKNIGWLNSLAYDIQEPYFDNRT-GGP 520
            :...||.|||:.|.|:|||:|||||.||..|:   |:....:|||:.|...::.||:.|.| |||
  Rat   351 HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGP 415

  Fly   521 SIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGT 585
            ||:|.||.|||||.:||||||||||:.||||||.|:||.||:|:||:|.:||||:|||||:||..
  Rat   416 SIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW 480

  Fly   586 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRK 650
            :.|||:...:::|||.|.:|..|:||:.||||..|:..||||.|.|||.||:.|::||.:|||::
  Rat   481 SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKE 545

  Fly   651 LLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLG 714
            :| ..:.|..||.||||:.||..||:...||:.|:.:||.|.::||:..||:|:.:...:: :||
  Rat   546 IL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILG 609

  Fly   715 KNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLV--ITYNMR 777
            |.|:.|.|..|...|.|:|..|:||||||:..:....|.:||..|||:...||.::.  :|||:|
  Rat   610 KGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLR 674

  Fly   778 DDEHSGV 784
            :...|.|
  Rat   675 EGHESDV 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
seiNP_476713.1 Ion_trans 322..583 CDD:459842 133/264 (50%)
CAP_ED 657..767 CDD:237999 45/110 (41%)
Kcnh8NP_659563.1 PAS_9 40..135 CDD:463873 22/96 (23%)
PLN03192 175..>615 CDD:215625 206/452 (46%)
Selectivity filter. /evidence=ECO:0000250 434..439 4/4 (100%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 551..668 47/116 (41%)
PRK11753 578..>656 CDD:236969 30/77 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 683..744
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..793
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 960..983
Blue background indicates that the domain is not in the aligned region.

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