DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Kcnh8

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_659563.1	Gene:	Kcnh8 / 246325	RGDID:	2549	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	657	Identity:	262/657 - (39%)
Similarity:	385/657 - (58%)	Gaps:	60/657 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 KRECLKKVKPMKGENAVETN-GIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLL 219
            :.|.::|....|....|||| .:.|:.:.|..:|.: ||..|     ..|.||       .....
  Rat    57 RTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVE-FKGEI-----MFYKKN-------GAPFW 108

  Fly   220 CSYD--PLRKNNADLFQTHKGTSYECMFKNL-----KYNQAEKPTDNVMGNS-----YDD--MLD 270
            |..|  |::....|:      ..:...||::     |....:|..|...|.|     :|.  ...
  Rat   109 CLLDIVPIKNEKGDV------VLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRS 167

  Fly   271 KEALLGSKSEPKGQDPNDMITSLGGNILLDQ------KLQNNYYHKWTLLHYSPFKAVWDWIILI 329
            :..|.......:.::.|.:  .:..|:.:|:      |:.:....|:.|||:|.|||.|||:||:
  Rat   168 RAVLYHISGHLQRREKNKL--KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILL 230

  Fly   330 LVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEV 394
            ...|.|:..||...| :|.:|.....|..::       |:.|::.||:|||:|||||:|:...:|
  Rat   231 ATFYVAVTVPYNVCF-IGNEDLSTTRSTTVS-------DIAVEILFIIDIILNFRTTYVSKSGQV 287

  Fly   395 VSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSE 459
            :.....|.:||::.||:|||:||:|||||...:.|  ..:|:.||||.|||||:|:.:|:||||:
  Rat   288 IFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQ 350

  Fly   460 YGAAVLILLMATFILIAHWLACIWYAIGNAEK---SIASKNIGWLNSLAYDIQEPYFDNRT-GGP 520
            :...||.|||:.|.|:|||:|||||.||..|:   |:....:|||:.|...::.||:.|.| |||
  Rat   351 HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGP 415

  Fly   521 SIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGT 585
            ||:|.||.|||||.:||||||||||:.||||||.|:||.||:|:||:|.:||||:|||||:||..
  Rat   416 SIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW 480

  Fly   586 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRK 650
            :.|||:...:::|||.|.:|..|:||:.||||..|:..||||.|.|||.||:.|::||.:|||::
  Rat   481 SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKE 545

  Fly   651 LLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLG 714
            :| ..:.|..||.||||:.||..||:...||:.|:.:||.|.::||:..||:|:.:...:: :||
  Rat   546 IL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILG 609

  Fly   715 KNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLV--ITYNMR 777
            |.|:.|.|..|...|.|:|..|:||||||:..:....|.:||..|||:...||.::.  :|||:|
  Rat   610 KGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLR 674

  Fly   778 DDEHSGV 784
            :...|.|
  Rat   675 EGHESDV 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	120/226 (53%)
		Ion_trans_2	<526..580	CDD:285168	39/53 (74%)
		CAP_ED	657..767	CDD:237999	45/110 (41%)
		Crp	666..>766	CDD:223736	40/100 (40%)
Kcnh8	NP_659563.1	PAS_9	29..135	CDD:290162	22/96 (23%)
		PAS	42..133	CDD:238075	22/94 (23%)
		Ion_trans	239..481	CDD:278921	128/251 (51%)
		Ion_trans_2	<421..475	CDD:285168	39/53 (74%)
		Selectivity filter. /evidence=ECO:0000250	434..439		4/4 (100%)
		Crp	548..707	CDD:223736	53/134 (40%)
		CAP_ED	551..662	CDD:237999	45/110 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..744
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..793
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840