DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sei and Kcnh5

DIOPT Version :10

Sequence 1:NP_476713.1 Gene:sei / 37843 FlyBaseID:FBgn0003353 Length:855 Species:Drosophila melanogaster
Sequence 2:NP_766393.2 Gene:Kcnh5 / 238271 MGIID:3584508 Length:988 Species:Mus musculus


Alignment Length:677 Identity:259/677 - (38%)
Similarity:372/677 - (54%) Gaps:68/677 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 LESKPSQHKKQKSFKKC-IKCDKKKLYIKNYQVSARRECDLLCSYDPLRKNNADLFQTHKGTSYE 242
            |..|.:..|.:::|... ..|.:..||.||     |..........|:|..:      .|...:.
Mouse    72 LTDKKTIEKVRQTFDNYESNCFEVLLYKKN-----RTPVWFYMQIAPIRNEH------EKVVLFL 125

  Fly   243 CMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPNDM------------ITSLGG 295
            |.||::...:.....|:..|.:....|.: ||..|:|..:...|.:.            :..||.
Mouse   126 CTFKDITLFKQPIEDDSTKGWTKFARLTR-ALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGS 189

  Fly   296 NILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYIN 360
            :||...|.:........:|||..||..|||:||||..||||..||..:|...:           |
Mouse   190 DILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ-----------N 243

  Fly   361 SDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV 425
            :...:::|.:|||.|:|||::||.||||....||:|.|..|.::||..||:|||::.:|:|::..
Mouse   244 NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINA 308

  Fly   426 GSDTDE-TTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNA 489
            ..:.|| .::|...||..|||||.|||||:|.|.|||||||:||:..|.|:|||||||||:||:.
Mouse   309 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDY 373

  Fly   490 EKSIASKNI----GWLNSLAYDIQEPYFDNRT-----GGPSIKSRYITALYFTFTSLTSVGFGNV 545
            |......|.    .||..||..|..||..|.:     ||||..|.|:::||||.||||::||||:
Mouse   374 EVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNI 438

  Fly   546 APNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 610
            ||.||.||.|::.:|:||||:||:|||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:
Mouse   439 APTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

  Fly   611 RLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            |:.:|....|:.:.|||...:|...|:.::||||:|||||:.....||..||.|||||.:::|:|
Mouse   504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568

  Fly   676 THAPPGDILVHRGDVLTSLYFIARGSIE-IQRAGNIVVLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            .|..|||::.|.|:.:.:|.|:..||:| ||....:.:|||.|:||:......|:..:...||||
Mouse   569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLAHACANVRAL 633

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSSPD 804
            ||||:|.:.|:.||.|||.|..|..||..||.:|.|:|          .|.:..|.||..:...:
Mouse   634 TYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR----------KRIIFRKISDVKKEEEE 688

  Fly   805 IPSIRIVGLRYKKQNVNTSV---HKVK 828
                   .|| :|..|..|:   |.|:
Mouse   689 -------RLR-QKNEVTLSIPVDHPVR 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
seiNP_476713.1 Ion_trans 322..583 CDD:459842 131/270 (49%)
CAP_ED 657..767 CDD:237999 49/110 (45%)
Kcnh5NP_766393.2 PAS_9 39..132 CDD:463873 16/70 (23%)
PLN03192 217..>616 CDD:215625 189/409 (46%)
Selectivity filter. /evidence=ECO:0000250 432..437 2/4 (50%)
Crp 551..758 CDD:440428 65/175 (37%)
Calmodulin-binding. /evidence=ECO:0000255 704..715 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..741
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..893
CAD (involved in subunit assembly). /evidence=ECO:0000250 909..948
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.