DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Kcnh5

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_766393.2	Gene:	Kcnh5 / 238271	MGIID:	3584508	Length:	988	Species:	Mus musculus

Alignment Length:	677	Identity:	259/677 - (38%)
Similarity:	372/677 - (54%)	Gaps:	68/677 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LESKPSQHKKQKSFKKC-IKCDKKKLYIKNYQVSARRECDLLCSYDPLRKNNADLFQTHKGTSYE 242
            |..|.:..|.:::|... ..|.:..||.||     |..........|:|..:      .|...:.
Mouse    72 LTDKKTIEKVRQTFDNYESNCFEVLLYKKN-----RTPVWFYMQIAPIRNEH------EKVVLFL 125

  Fly   243 CMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQDPNDM------------ITSLGG 295
            |.||::...:.....|:..|.:....|.: ||..|:|..:...|.:.            :..||.
Mouse   126 CTFKDITLFKQPIEDDSTKGWTKFARLTR-ALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGS 189

  Fly   296 NILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYIN 360
            :||...|.:........:|||..||..|||:||||..||||..||..:|...:           |
Mouse   190 DILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ-----------N 243

  Fly   361 SDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV 425
            :...:::|.:|||.|:|||::||.||||....||:|.|..|.::||..||:|||::.:|:|::..
Mouse   244 NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINA 308

  Fly   426 GSDTDE-TTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNA 489
            ..:.|| .::|...||..|||||.|||||:|.|.|||||||:||:..|.|:|||||||||:||:.
Mouse   309 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDY 373

  Fly   490 EKSIASKNI----GWLNSLAYDIQEPYFDNRT-----GGPSIKSRYITALYFTFTSLTSVGFGNV 545
            |......|.    .||..||..|..||..|.:     ||||..|.|:::||||.||||::||||:
Mouse   374 EVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNI 438

  Fly   546 APNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 610
            ||.||.||.|::.:|:||||:||:|||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:
Mouse   439 APTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

  Fly   611 RLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            |:.:|....|:.:.|||...:|...|:.::||||:|||||:.....||..||.|||||.:::|:|
Mouse   504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568

  Fly   676 THAPPGDILVHRGDVLTSLYFIARGSIE-IQRAGNIVVLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            .|..|||::.|.|:.:.:|.|:..||:| ||....:.:|||.|:||:......|:..:...||||
Mouse   569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLAHACANVRAL 633

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSSPD 804
            ||||:|.:.|:.||.|||.|..|..||..||.:|.|:|          .|.:..|.||..:...:
Mouse   634 TYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR----------KRIIFRKISDVKKEEEE 688

  Fly   805 IPSIRIVGLRYKKQNVNTSV---HKVK 828
                   .|| :|..|..|:   |.|:
Mouse   689 -------RLR-QKNEVTLSIPVDHPVR 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	117/232 (50%)
		Ion_trans_2	<526..580	CDD:285168	33/53 (62%)
		CAP_ED	657..767	CDD:237999	49/110 (45%)
		Crp	666..>766	CDD:223736	42/100 (42%)
Kcnh5	NP_766393.2	PAS	37..131	CDD:238075	16/69 (23%)
		PAS_3	40..127	CDD:285623	13/65 (20%)
		Ion_trans	232..479	CDD:278921	121/257 (47%)
		Ion_trans_2	<419..473	CDD:285168	33/53 (62%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	544..723	CDD:223736	66/182 (36%)
		CAP_ED	550..660	CDD:237999	48/109 (44%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..893
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258139at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920