DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and KCNH4

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_036417.1	Gene:	KCNH4 / 23415	HGNCID:	6253	Length:	1017	Species:	Homo sapiens

Alignment Length:	553	Identity:	247/553 - (44%)
Similarity:	347/553 - (62%)	Gaps:	50/553 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 EPKGQDPNDMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAF 344
            |||...|...:.|:||:..|             |||||..||:||.:||:...|.|:..||...|
Human   199 EPKPSVPEYKVASVGGSRCL-------------LLHYSVSKAIWDGLILLATFYVAVTVPYNVCF 250

  Fly   345 LLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGW 409
             .|:.|..      |.|...::.|:.|::.||:|||:|||||:|:...:|:|.|..|.:|||:.|
Human   251 -SGDDDTP------ITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATW 308

  Fly   410 FLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFIL 474
            |.|||:||:|||||.:.:.|  .|:|:.||||.|||||:|:.:|::|||:..|.||.|||:.|.|
Human   309 FFIDLIAALPFDLLYIFNIT--VTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFAL 371

  Fly   475 IAHWLACIWYAIGNAEKSIASK---NIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTS 536
            :|||:|||||.||..|......   :||||:.|...::.||.:...||||.:|.||.|||||.:|
Human   372 LAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSS 436

  Fly   537 LTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRF 601
            |||||||||..||||||.|:||.||:|:||:|.:||||:|||||:||..:.||::|..:::|||.
Human   437 LTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRV 501

  Fly   602 HQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCL 666
            |::|.||:||:.||||..|...:|||.|.||:.||:.|:|||.:||||::| ....|..||.|||
Human   502 HRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCL 565

  Fly   667 RAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGEN---PCIYP 727
            ||.||..||:...||:.|:.|||.|.:.|::..||:|:.|...:: :|||.|:.|.:   |...|
Human   566 RALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEP 630

  Fly   728 TVG-------KSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLV--ITYNMRD-DEHS 782
            .:|       |::..|:|||||.:.:|....|.:||..|||:..:|.:.|.  :|:|:|. .:.|
Human   631 GLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTS 695

  Fly   783 GVDIKHRYLRA-----KSSDKMRSSPD--IPSI 808
            |:.   |:.|:     ..|:.:.||.|  :|||
Human   696 GLS---RFSRSPRLSQPRSESLGSSSDKTLPSI 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	122/225 (54%)
		Ion_trans_2	<526..580	CDD:285168	39/53 (74%)
		CAP_ED	657..767	CDD:237999	46/120 (38%)
		Crp	666..>766	CDD:223736	41/110 (37%)
KCNH4	NP_036417.1	PAS_9	29..135	CDD:290162
		PAS	29..133	CDD:238075
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..157
		Ion_trans	244..486	CDD:278921	130/250 (52%)
		Ion_trans_2	<426..480	CDD:285168	39/53 (74%)
		Selectivity filter. /evidence=ECO:0000250	439..444		4/4 (100%)
		CAP_ED	556..676	CDD:237999	46/119 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..749		11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..875
		PHA02682	838..>999	CDD:177464
		bZIP	<872..901	CDD:304365
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145040
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740