DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Cnga4

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001028489.1	Gene:	Cnga4 / 233649	MGIID:	2664099	Length:	575	Species:	Mus musculus

Alignment Length:	506	Identity:	117/506 - (23%)
Similarity:	224/506 - (44%)	Gaps:	75/506 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 NYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLI 370
            :||:.|  |:...|..:::   ||:|:..|.|.....::|:.                ..::|..
Mouse    32 DYYYWW--LNTMVFPIMYN---LIIVVCRACFPDLQHSYLVA----------------WFVLDYT 75

  Fly   371 VDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGW-FLIDLVAAVPFDLLLVGSDTDETTT 434
            .|:.:::||.:.|.|.|: .|..:|.....||..|:..| ||:||.:.||         ||....
Mouse    76 SDLLYLLDIGVRFHTGFL-EQGILVVDKSMIASRYVRTWSFLLDLASLVP---------TDAAYV 130

  Fly   435 LIG-LLKTARLLRLVRVARKIDRY------SEYGAAVLIL-LMATFILIAHWLACIWYAIGNAEK 491
            .:| .:.|.||.|.:||.|..:.:      :.|..|..|. ||....::.||.:|:::|:
Mouse   131 QLGPHIPTLRLNRFLRVPRLFEAFDRTETRTAYPNAFRIAKLMIYIFVVIHWNSCLYFAL----- 190

  Fly   492 SIASKNIG-----WLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDA 551
               |:.:|     |:..   |..:|.|:.      ::.:|:.:.||:...||:|| ....|..:.
Mouse   191 ---SRYLGFGRDAWVYP---DPAQPGFER------LRRQYLYSFYFSTLILTTVG-DTPLPAREE 242

  Fly   552 EKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYF 616
            |..|.:...|:..:.:|:|.|::|::|..:.:..|.::.....|:::::...:...|.:|:.:::
Mouse   243 EYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRRLERRVIDWY 307

  Fly   617 QHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPG 681
            ||........:..::|:..||.|:|::.:.::...|:....|.......|....||.:.....||
Mouse   308 QHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPG 372

  Fly   682 DILVHRGDVLTSLYFIARGSIEIQRAGNI---VVLGKNDIFGENPCIYPTVGKSNG-----VVRA 738
            :.:..:||:...:|.|..|.:.:.....:   .|||....||| ..|....|..:|     .:::
Mouse   373 EYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKS 436

  Fly   739 LTYCDIHKLHRDDLLDVLDSYPE---FLESFVSNLVITYNMRDDEHSGVDI 786
            |.|.|:..|.::||.:||..||:   .:|.....:::..|..|......:|
Mouse   437 LGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	60/236 (25%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	31/120 (26%)
		Crp	666..>766	CDD:223736	30/110 (27%)
Cnga4	NP_001028489.1	Ion_trans	34..273	CDD:366146	70/287 (24%)
		IQ-type. /evidence=ECO:0000250	292..302		1/9 (11%)
		CAP_ED	348..464	CDD:237999	30/116 (26%)
		CLZ	464..534	CDD:374604	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840