DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Kcnh7

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_006234331.1	Gene:	Kcnh7 / 170739	RGDID:	621112	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	404/837 - (48%)
Similarity:	517/837 - (61%)	Gaps:	137/837 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DNAAKKPPVKEFKRNCPAKSNKFVERELFSLMCNLNKIEKKQVFVSDILINASMFDDKKESLARF 97
            ||||....|...   .|.||   |.|:||..                                :|
  Rat   136 DNAASPERVNPI---LPVKS---VNRKLFGF--------------------------------KF 162

  Fly    98 PKNVSDHNTLVYHKFLRTRPTNDDEALKLKAGGKSKERPGTKITADCFFSPLLFKINNKRECLKK 162
            |    ....|.|.|  ::.|..|.:.:.:.:...|.:....|          .||...|..|...
  Rat   163 P----GLRVLTYRK--QSLPQEDPDVVVIDSSKHSDDSVAMK----------HFKSPTKESCSPS 211

  Fly   163 --------VKPMKGENAVETNGIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLL 219
                    ::|.:....|..:| ||:....:.:..:.:...::        .:.|::..|..:.|
  Rat   212 EADDTKALIQPSQCSPLVNISG-PLDHSSPKRQWDRLYPDMLQ--------SSSQLTHSRSRESL 267

  Fly   220 CSYDPLRK----NNADLFQTHKGTSY------ECMFKNLKYNQ---AEKPTDNV----MGNSYDD 267
            ||   :|:    ::.:.|..|....:      |...:|:|.::   |..|.:::    :|::.|.
  Rat   268 CS---IRRASSVHDIEGFNVHPKNIFRDRHASEDNGRNVKVSRSWMAGGPFNHIKSSLLGSTSDS 329

  Fly   268 MLDKEALLGS-----------KSEPKGQDPND----------------------MITSLGGNILL 299
            .|:|.:.:..           |:|.|...|..                      .:.|||.::|.
  Rat   330 NLNKYSTINKIPQLTLNFSDVKTEKKNTSPPSSDKTIIAPKVKERTHNVTEKVTQVLSLGADVLP 394

  Fly   300 DQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPI 364
            :.|||....:|:|:||||||||||||:||:||:||||||||.|||||.:::.|:|.....:..|:
  Rat   395 EYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPL 459

  Fly   365 VIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDT 429
            .::|||||:.||:||:||||||:||..:||||.|.:|||||..||||||:|||:|||||:.||.:
  Rat   460 NVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAVHYFKGWFLIDMVAAIPFDLLIFGSGS 524

  Fly   430 DETTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAEKSIA 494
            ||||||||||||||||||||||||:|||||||||||:|||..|.|||||||||||||||.|:...
  Rat   525 DETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYL 589

  Fly   495 SKNIGWLNSLAYDIQEPYFD-NRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTIC 558
            :..||||:||...|.:.|.| :.:.|||||.:|:|||||||:||||||||||:|||::||.|:||
  Rat   590 TDKIGWLDSLGTQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSIC 654

  Fly   559 VMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYT 623
            |||:|||||||||||||||||||||||||||.|||||:|||||||||||||||||||||||||||
  Rat   655 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYT 719

  Fly   624 NGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRG 688
            ||||||.:|||||||||||||||||:.||..|.||..||.|||||.::|||||||||||.|||.|
  Rat   720 NGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCG 784

  Fly   689 DVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDL 752
            ||||:|||::||||||.:...:| :|||||||||...:|...||||..||||||||:||:.|:||
  Rat   785 DVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDL 849

  Fly   753 LDVLDSYPEFLESFVSNLVITYNMR----------DDEHSGVDIKHRYLRAKS-SDK 798
            |:|||.||||.:.|::||.:|:|:|          |.|.....::.|.|..:| .||
  Rat   850 LEVLDMYPEFSDHFLTNLELTFNLRHESAKSQSINDSEGDTCKLRRRRLSFESEGDK 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	161/223 (72%)
		Ion_trans_2	<526..580	CDD:285168	45/53 (85%)
		CAP_ED	657..767	CDD:237999	73/110 (66%)
		Crp	666..>766	CDD:223736	67/100 (67%)
Kcnh7	XP_006234331.1	PAS_9	29..134	CDD:290162
		PAS	41..130	CDD:238075
		Ion_trans	456..679	CDD:278921	161/222 (73%)
		Ion_trans_2	<622..676	CDD:285168	45/53 (85%)
		Crp	747..>877	CDD:223736	82/129 (64%)
		CAP_ED	753..864	CDD:237999	73/110 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338731
Domainoid	1	1.000	385	1.000	Domainoid score	I773
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I617
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm45204
orthoMCL	1	0.900	-	-		OOG6_100845
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750