DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Kcnh3

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_006520546.1	Gene:	Kcnh3 / 16512	MGIID:	1341723	Length:	1101	Species:	Mus musculus

Alignment Length:	559	Identity:	225/559 - (40%)
Similarity:	315/559 - (56%)	Gaps:	85/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 KSEPK----------GQDPNDMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVM 332
            :.:||          |:.||          |.:.|:.......:.|||....:|.||..||:..:
Mouse   188 QKQPKGKHKLNKGVFGEKPN----------LPEYKVAAIRKSPFILLHCGALRATWDGFILLATL 242

  Fly   333 YTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSH 397
            |.|:..||........:....|.       |..:.||.|:|.||:||::|||||||:...:||..
Mouse   243 YVAVTVPYSVCVSTAREPSAARG-------PPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFA 300

  Fly   398 PGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIG--LLKTARLLRLVRVARKIDRYSEY 460
            |..|.:||::.|||:|::||:|||||    ...:....:|  ||||.|||||:|:..::||||:|
Mouse   301 PKSICLHYVTTWFLLDVIAALPFDLL----HAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQY 361

  Fly   461 GAAVLILLMATFILIAHWLACIWYAIGNAE-KSIASK--NIGWLNSLAYDIQEPYF--------- 513
            .|.||.||||.|.|:|||:||:|:.||..| :|..|:  .||||..||..::.||:
Mouse   362 SAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGG 426

  Fly   514 -------------------------DNRT-----GGPSIKSRYITALYFTFTSLTSVGFGNVAPN 548
                                     .|.|     ||||::|.|||:|||..:||||||||||:.|
Mouse   427 NSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSAN 491

  Fly   549 TDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLE 613
            ||.||.|:||.||:|:||:|.:||||:|||||:|:....||::...:|::||.|:||.||:||:.
Mouse   492 TDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRML 556

  Fly   614 EYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHA 678
            ||||..|...||||...||:..|:.|:|||.:||::::| ....|..||.|||||.||..:....
Mouse   557 EYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFC 620

  Fly   679 PPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYP---TVGKSNGVVRAL 739
            .||:.|:|:||.|.:|||:..||:|:.:.|.:: :|||.|:.|   |..|   .|.|:|..|:.|
Mouse   621 TPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIG---CELPQREQVVKANADVKGL 682

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVSNL--VITYNM 776
            |||.:..|....|.:.|..||||...|...|  .::||:
Mouse   683 TYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNL 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	123/266 (46%)
		Ion_trans_2	<526..580	CDD:285168	37/53 (70%)
		CAP_ED	657..767	CDD:237999	46/113 (41%)
		Crp	666..>766	CDD:223736	41/103 (40%)
Kcnh3	XP_006520546.1	PAS_9	40..135	CDD:379177
		PLN03192	233..>668	CDD:215625	194/449 (43%)
		cyc_nuc_ocin	<623..718	CDD:274839	37/97 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740