DRSC/TRiP Functional Genomics Resources

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Protein Alignment sei and Kcnh1

DIOPT Version :10

Sequence 1:NP_476713.1 Gene:sei / 37843 FlyBaseID:FBgn0003353 Length:855 Species:Drosophila melanogaster
Sequence 2:NP_034730.1 Gene:Kcnh1 / 16510 MGIID:1341721 Length:989 Species:Mus musculus


Alignment Length:823 Identity:281/823 - (34%)
Similarity:415/823 - (50%) Gaps:146/823 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 AGGKSKERPGTKITADCFFSPLLFKINNKRECLKKVKPMKGENAVETNGIPLESKPSQHKKQKSF 192
            |||    |.|.....:.|...::.:.|:....|...:.:........:|.   .|.|.:.:.:..
Mouse     4 AGG----RRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGF---CKLSGYHRAEVM 61

  Fly   193 KKCIKC-------------DKKKLYIKNYQVSARRECDLLCSYDPL--RKNNADLF--------- 233
            :|...|             :|.:...:||:::         |::.|  :||...::         
Mouse    62 QKSSACSFMYGELTDKDTVEKVRQTFENYEMN---------SFEILMYKKNRTPVWFFVKIAPIR 117

  Fly   234 -QTHKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSK--------SEPKGQDPND- 288
             :..|...:.|.|.::...:.....|:..|......|.: ||..|:        |..||::.:. 
Mouse   118 NEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTR-ALTSSRGVLQQLAPSVQKGENVHKH 181

  Fly   289 ----MITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQ 349
                .:..||.:||...|.:........:|||..||..||||||||..||||..||..:|...: 
Mouse   182 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQ- 245

  Fly   350 DYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDL 414
                      |:...:::|.||||.|:|||::||.||||....||:|.|..|.::||..||:|||
Mouse   246 ----------NNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

  Fly   415 VAAVPFDLLLVGSDTDETTTLIG----------------------------LLKTARLLRLVRVA 451
            ::.:|:|::....:.||.:..:|                            .||..|||||.|||
Mouse   301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVA 365

  Fly   452 RKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAE------KSIASKNIGWLNSLAYDIQE 510
            ||:|.|.|||||||:||:..|.|.|||:|||||:||:.|      |:|  :|..||..||.||..
Mouse   366 RKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTI--RNNSWLYQLALDIGT 428

  Fly   511 PYFDNRT------GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYAS 569
            ||..|.:      ||||..|.||::||||.||||||||||:||:||.||.|.:.:|::|||:||:
Mouse   429 PYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 493

  Fly   570 IFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKG 634
            |||||:.|.|::|:.|.|||..:..||:|::.:|:|..|.:|:.:|....|:.:.|||...:|:.
Mouse   494 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQI 558

  Fly   635 FPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIAR 699
            .|:.::||||:|||||:.....||..||.|||||.:::|:|.|..|||::.|.|:.:.||.|:..
Mouse   559 CPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVS 623

  Fly   700 GSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFL 763
            ||:|:.:...:| :|||.|:||:......|:.:|...||||||||:|.:.||.|..||:.|..|.
Mouse   624 GSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688

  Fly   764 ESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSS---------------PDIPSIRIVGL 813
            .||..||::|||:|          .|.:..|.||..|..               ||.| :|.:..
Mouse   689 HSFSRNLILTYNLR----------KRIVFRKISDVKREEEERMKRKNEAPLILPPDHP-VRRLFQ 742

  Fly   814 RYKKQNVNTSVHKVKNDNSRDL--------NIFIENEIANYHL 848
            |:::|.   ..........|||        |...::..||:.|
Mouse   743 RFRQQK---EARLAAERGGRDLDDLDVEKGNALTDHTSANHSL 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
seiNP_476713.1 Ion_trans 322..583 CDD:459842 137/300 (46%)
CAP_ED 657..767 CDD:237999 49/110 (45%)
Kcnh1NP_034730.1 PAS_9 41..135 CDD:463873 15/105 (14%)
Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250|UniProtKB:O95259 151..162 3/11 (27%)
PLN03192 220..>647 CDD:215625 195/439 (44%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472 463..468 4/4 (100%)
PRK11753 608..>712 CDD:236969 43/113 (38%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:27618660 673..770 29/110 (26%)
Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000269|PubMed:22732247 699..701 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 857..905
CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472 924..964
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..989
Blue background indicates that the domain is not in the aligned region.

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