DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and KCNH8

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_016861187.1	Gene:	KCNH8 / 131096	HGNCID:	18864	Length:	1108	Species:	Homo sapiens

Alignment Length:	685	Identity:	269/685 - (39%)
Similarity:	400/685 - (58%)	Gaps:	64/685 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 KRECLKKVKPMKGENAVETN-GIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLL 219
            :.|.::|....|....|||| .:.|:.:.|..:|.: ||..|     ..|.||       .....
Human    57 RTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKTE-FKGEI-----MFYKKN-------GSPFW 108

  Fly   220 CSYD--PLRKNNADLFQTHKGTSYECMFKNL-----KYNQAEKPTDNVMGNS-----YDD--MLD 270
            |..|  |::....|:      ..:...||::     |....:|..|.|.|.|     :|.  ...
Human   109 CLLDIVPIKNEKGDV------VLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRS 167

  Fly   271 KEALLGSKSEPKGQDPNDMITSLGGNILLDQ------KLQNNYYHKWTLLHYSPFKAVWDWIILI 329
            :..|.......:.::.|.:  .:..|:.:|:      |:.:....|:.|||:|.|||.|||:||:
Human   168 RAVLYHISGHLQRREKNKL--KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILL 230

  Fly   330 LVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEV 394
            ...|.|:..||...| :|..|.....|..::       |:.|::.||:|||:|||||:|:...:|
Human   231 ATFYVAVTVPYNVCF-IGNDDLSTTRSTTVS-------DIAVEILFIIDIILNFRTTYVSKSGQV 287

  Fly   395 VSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVARKIDRYSE 459
            :.....|.:||::.||:|||:||:|||||...:.|  ..:|:.||||.|||||:|:.:|:||||:
Human   288 IFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQ 350

  Fly   460 YGAAVLILLMATFILIAHWLACIWYAIGNAEK---SIASKNIGWLNSLAYDIQEPYFDNRT-GGP 520
            :...||.|||:.|.|:|||:|||||.||..|:   |:....:|||:.|...::.||:.|.| |||
Human   351 HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGP 415

  Fly   521 SIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGT 585
            ||:|.||.|||||.:||||||||||:.||||||.|:||.||:|:||:|.:||||:|||||:||..
Human   416 SIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW 480

  Fly   586 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRK 650
            :.|||:...:::|||.|.:|..|:||:.||||..|:..||||.|.|||.||:.|::||.:|||::
Human   481 SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKE 545

  Fly   651 LLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIV-VLG 714
            :| ..:.|..||.||||:.||..||:...||:.|:.:||.|.::||:..||:|:.:...:: :||
Human   546 IL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILG 609

  Fly   715 KNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLV--ITYNMR 777
            |.|:.|.|..|...|.|:|..|:||||||:..:....|.:|||.|||:...||.::.  :|||:|
Human   610 KGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLR 674

  Fly   778 DDEHSGV--DIKHRYLRAKSSDKMRSSPD--IPSI 808
            :...|.|  .:.::.:.::|..|...:.:  :|||
Human   675 EGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSI 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	120/226 (53%)
		Ion_trans_2	<526..580	CDD:285168	39/53 (74%)
		CAP_ED	657..767	CDD:237999	46/110 (42%)
		Crp	666..>766	CDD:223736	41/100 (41%)
KCNH8	XP_016861187.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740