DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Cnga3

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001268939.1	Gene:	Cnga3 / 12790	MGIID:	1341818	Length:	669	Species:	Mus musculus

Alignment Length:	680	Identity:	161/680 - (23%)
Similarity:	294/680 - (43%)	Gaps:	120/680 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 KCIKCDKKKLYIKNYQVSARRECD-----LLCSYDPLRKNNADLFQ-----------------TH 236
            :|.:....:|.|||    |.|:.|     |..|:.|..:.::.|.|                 |.
Mouse     7 QCSQPSPTQLSIKN----ADRDLDHVENGLGRSHSPCEETSSTLQQGIAMETRGLAGSARSVVTS 67

  Fly   237 KG--------TSYECMFKNLKYNQAEKP---TDNVMGNSYDDMLDKEALLGSKSEPKGQDPNDMI 290
            :|        .|.........:::.:.|   .|...|:...::..:|:  .::..|..|.|.|
Mouse    68 QGPARVSRLIISIRAWASRHLHDEDQTPDSFLDRFHGSELKEVSTRES--NAQPNPGEQKPPD-- 128

  Fly   291 TSLGGN------ILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILIL-VMYTAIFTPYVAAFLLGE 348
               ||.      |::|.  .:|.|::|......|  ..::|.:|:. ..:..:.:.::..:|
Mouse   129 ---GGEGRKEEPIVVDP--SSNIYYRWLTAIALP--VFYNWCLLVCRACFDELQSEHLTLWL--- 183

  Fly   349 QDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSG-WFLI 412
                             ::|...||.:::|:::..||.|: .|..:|....|:..||... .|.:
Mouse   184 -----------------VLDYSADVLYVLDMLVRARTGFL-EQGLMVRDTKRLWKHYTKTLHFKL 230

  Fly   413 DLVAAVPFDL--LLVGSDTDETTTLIGLLKTARLLRLVRVARKIDR---YSEYGAAVLI--LLMA 470
            |:::.:|.||  |.:|.:..|       |:..|||:..|:....||   .:.|.....|  |::.
Mouse   231 DILSLIPTDLAYLKLGVNYPE-------LRFNRLLKFSRLFEFFDRTETRTNYPNVFRIGNLVLY 288

  Fly   471 TFILIAHWLACIWYAIGNAEKSIASKNIGW-LNSLAY-DIQEPYFDNRTGGPSIKSRYITALYFT 533
            |.|:| ||.|||::||        ||.||: .:|..| :..:|.:      ..:..:||.:||::
Mouse   289 TLIII-HWNACIYFAI--------SKFIGFGTDSWVYPNTSKPEY------ARLSRKYIYSLYWS 338

  Fly   534 FTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 598
            ..:||::| ....|..|.|..|.:...|||.|::|:|.|||.::|..:.:....:..::..|:::
Mouse   339 TLTLTTIG-ETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRVEFQAKIDSVKQY 402

  Fly   599 IRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASP 663
            ::|.::...|..|:..:|.:.|.....:|...:||..|:.|:|:|.::::...|.....|.:...
Mouse   403 MQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEA 467

  Fly   664 GCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNI---VVLGKNDIFGENPCI 725
            |.|....||.:.|...|||.:..:||:...:|.|..|.:.:.....:   |||.....|||...:
Mouse   468 GLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISIL 532

  Fly   726 YPTVGKS----NGVVRALTYCDIHKLHRDDLLDVLDSYPE---FLESFVSNLVITYNMRDDEHSG 783
            .....||    ...:|::.|.|:..|.:|||::.|..||:   .||.....:::..|:.|::...
Mouse   533 NIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKRALEEKGRQILMKDNLIDEDLVA 597

  Fly   784 VDIKHRYLRAKSSDKMRSSPDIPSIRIVGL 813
            ..:..|.:..| .:.:.||.||...|...|
Mouse   598 ARVDTRDVEEK-VEYLESSLDILQTRFARL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	68/232 (29%)
		Ion_trans_2	<526..580	CDD:285168	21/53 (40%)
		CAP_ED	657..767	CDD:237999	34/119 (29%)
		Crp	666..>766	CDD:223736	32/109 (29%)
Cnga3	NP_001268939.1	Ion_trans	165..387	CDD:278921	70/265 (26%)
		Radical_SAM	422..>475	CDD:302752	12/52 (23%)
		Crp	455..>577	CDD:223736	33/121 (27%)
		CAP_ED	461..577	CDD:237999	32/115 (28%)
		CLZ	577..647	CDD:293134	12/51 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840