Protein Alignment sei and CNGA4

DIOPT Version :10

• Sequence 1: NP_476713.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_016872706.1
• Gene: CNGA4 / 1262
• HGNCID: 2152
• Length: 577
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 119/516 - (23%)
• Similarity: 236/516 - (45%)
• Gaps: 68/516 - (13%)

  Fly   306 NYYHKWTLLHYSPFKAVWDWIILIL-VMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDL 369
            :||:.|  |:...|..:::.|||:. ..:..:...|:.|:|                    ::|.
Human    32 DYYYWW--LNTMVFPVMYNLIILVCRACFPDLQHGYLVAWL--------------------VLDY 74

  Fly   370 IVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGW-FLIDLVAAVPFDLLLVGSDTDETT 433
            ..|:.:::|:::.|.|.|: .|..:|...|||:..|:..| |.:||.:.:|.|::.|.......|
Human    75 TSDLLYLLDMVVRFHTGFL-EQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPT 138

  Fly   434 TLIGLLKTARLLRLVRVARKIDR---YSEYGAAVLI--LLMATFILIAHWLACIWYAIGNAEKSI 493
                 |:..|.||..|:....||   .:.|..|..|  |::..|::| ||.:|:::|:
Human   139 -----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWNSCLYFAL------- 190

  Fly   494 ASKNIGW-LNSLAY-DIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFT 556
             |:.:|: .::..| |..:|.|:.      ::.:|:.:.||:...||:|| ....|..:.|..|.
Human   191 -SRYLGFGRDAWVYPDPAQPGFER------LRRQYLYSFYFSTLILTTVG-DTPPPAREEEYLFM 247

  Fly   557 ICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWT 621
            :...|:..:.:|:|.|::|::|..:.:..|.::.....|:::::...:...|.:|:.:::||...
Human   248 VGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQI 312

  Fly   622 YTNGIDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVH 686
            .....:..::|:..||.|:|::.:.::...|:....|.......|....||.:.....||:.:..
Human   313 NKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCR 377

  Fly   687 RGDVLTSLYFIARGSIEIQRAGNI---VVLGKNDIFGENPCI-YPTVGKSNG-----VVRALTYC 742
            :||:...:|.|..|.:.:.....|   .|||....|||...| ....|..:|     .:::|.|.
Human   378 KGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKATGNMSGNRRTANIKSLGYS 442

  Fly   743 DIHKLHRDDLLDVLDSYPE---FLESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMR 800
            |:..|.::||.:||..||:   .:|.....:::..|..|......:|.   |:..:..::|
Human   443 DLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIA---LQEATESRLR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_476713.1	Ion_trans	322..583	CDD:459842	65/269 (24%)
		CAP_ED	657..767	CDD:237999	32/121 (26%)
CNGA4	XP_016872706.1	Ion_trans	34..273	CDD:459842	69/282 (24%)
		CAP_ED	348..466	CDD:237999	31/117 (26%)
		CLZ	466..536	CDD:465160	6/38 (16%)