DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and Hcn2

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_446136.1	Gene:	Hcn2 / 114244	RGDID:	620689	Length:	863	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	142/577 - (24%)
Similarity:	244/577 - (42%)	Gaps:	112/577 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 GSKSEPKGQDPNDMITSLGG-----------NILLDQKLQNNYYHK------WTLLHYSPFKAVW 323
            |...||:|...:.:....|.           .:...||.......:      |.:..||.|:..|
  Rat   123 GPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYW 187

  Fly   324 DWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTFV 388
            |:.:|:.::...|..|....|...|           .:.|.::.:::.|..|::|:::||||..|
  Rat   188 DFTMLLFMVGNLIIIPVGITFFKDE-----------TTAPWIVFNVVSDTFFLMDLVLNFRTGIV 241

  Fly   389 -NSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLV----GSDTDETTTLIGL--------LK 440
             ....|::..|.:|...||..||::|.|:::|.|.:.:    |.|::...|...|        |.
  Rat   242 IEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILS 306

  Fly   441 TARLLRLVRVARKIDRYSE-----YGAAVLIL----LMATFILIAHWLACI-------------- 482
            ..|||||.|:.|.|.::.|     |..|..::    |::..:|:.||..|:
  Rat   307 LLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDC 371

  Fly   483 WYAIGNAEKSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAP 547
            |.:|.|      ..|..|                      ...|..||:...:.:..:|:|..||
  Rat   372 WVSINN------MVNHSW----------------------SELYSFALFKAMSHMLCIGYGRQAP 408

  Fly   548 NTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRL 612
            .:..:...|:..|:||:..||...|:.:|:||.|.|...:|..:..:|.:::.||::|...||::
  Rat   409 ESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKI 473

  Fly   613 EEYFQHAWTYTNG--IDMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKT 675
            .:|::|.:   .|  .|.:|:|......|:.:|.....|||:.:...|:.|.|..:.|...|.|.
  Rat   474 HDYYEHRY---QGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKF 535

  Fly   676 THAPPGDILVHRGDVLTSLYFIARGSIEIQRAGN-IVVLGKNDIFGENPCIYPTVGKSNGVVRAL 739
            ....|||.::..|.:...:|||..|.:.:...|| .:.|.....||| .|:. |.|:....|||.
  Rat   536 EVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGE-ICLL-TRGRRTASVRAD 598

  Fly   740 TYCDIHKLHRDDLLDVLDSYPEFLESFVS------------NLVITYNMRDDEHSGV 784
            |||.::.|..|:..:||:.||....:|.:            |.::.:.::.|..|||
  Rat   599 TYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGV 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	64/258 (25%)
		Ion_trans_2	<526..580	CDD:285168	16/53 (30%)
		CAP_ED	657..767	CDD:237999	35/110 (32%)
		Crp	666..>766	CDD:223736	32/100 (32%)
Hcn2	NP_446136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		3/7 (43%)
		Involved in subunit assembly. /evidence=ECO:0000250	131..182		5/50 (10%)
		Ion_trans_N	140..182	CDD:285597	5/41 (12%)
		Ion_trans	202..447	CDD:278921	68/283 (24%)
		Crp	511..>646	CDD:223736	38/136 (28%)
		CAP_ED	517..625	CDD:237999	35/109 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810