DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and hcn4

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_002944030.2	Gene:	hcn4 / 100498501	XenbaseID:	XB-GENE-940130	Length:	2061	Species:	Xenopus tropicalis

Alignment Length:	738	Identity:	181/738 - (24%)
Similarity:	296/738 - (40%)	Gaps:	156/738 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 PMKGENAVETNGIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNY-------QVSARRECDLLC-- 220
            |.:|...|.|.| .::| |:|...|...|...:|   .|::.:.       |.:|:..|.|..
Frog  1087 PFQGSCHVPTQG-SIQS-PAQEPSQSPAKVPSQC---PLHVPSQCPVRVPTQATAQDSCPLTAQA 1146

  Fly   221 -SYDPLRKNNADLFQTHKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSEPKGQ 284
             |..|.:      ..:|.....          .::.|...:     ..::.|  |.||:....|
Frog  1147 PSQSPAQ------ISSHSPAQI----------SSQSPAQEL-----SSLIPK--LEGSEQTEVG- 1187

  Fly   285 DPNDMITSLGGNILLDQKLQNNY------YHK--------------WTLLHYSPFKAVWDWIILI 329
            ||...|....|.:|  |...|.:      .||              |.:..||.|:..||.|:|:
Frog  1188 DPGGFIQRQFGALL--QPAVNKFSLRMFGSHKAVEIEQQRVKSAGSWIIHPYSDFRFYWDLIMLL 1250

  Fly   330 LVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRT-TFVNSQDE 393
            |::...|..|....|...|           |:.|.::.:::.|..|:.|:::|||| ..|....|
Frog  1251 LMVANLIILPVGITFFKDE-----------NTPPWIVFNVLSDTFFLADLVLNFRTGIVVEDNTE 1304

  Fly   394 VVSHPGRIAVHYLSGWFLIDLVAAVPFD--LLLVGSDTDETTTL------------IGLLKTARL 444
            ::..|..|.:.||..|||:|.|:::|.|  .|:|..:|:..|.:            ..:|...||
Frog  1305 IILDPHTIKMKYLKSWFLVDFVSSIPVDYIFLIVDLETNVDTEVYKTARALRIVRFTKILSLLRL 1369

  Fly   445 LRLVRVARKIDRYSE-----YGAAVLIL----LMATFILIAHWLACIWYAIGNAEKSIASKNIGW 500
            |||.|:.|.|.::.|     |..|..::    |:...:|:.||..|:.:.:
Frog  1370 LRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLV-------------- 1420

  Fly   501 LNSLAYDIQEPYF--DNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVG 563
              .:..|..|..:  .|.....|...:|..|::...:.:..:|:|..||....:...|:..|:||
Frog  1421 --PMLQDFPEDCWVSINHMANESWGKQYSHAIFKAMSHMLCIGYGQQAPEGMTDVWLTMLSMIVG 1483

  Fly   564 SLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNG--I 626
            :..||...|:.:|:||.|.|...:|..:..:|.:::.||::|...|||:.||::|.:   .|  .
Frog  1484 ATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHEYYEHRY---QGKMF 1545

  Fly   627 DMNSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVL 691
            |..::|....|.|:.:|.....|.|:.....|:.|.|..:.|...|.:.....|||.::..|.|.
Frog  1546 DEENILGELSEPLKEEIVNFNCRNLVANMPLFANADPNFVTAMLTKLRFEVFQPGDYIIREGTVG 1610

  Fly   692 TSLYFIARGSIEI-QRAGNIVVLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDV 755
            ..:|||..|.:.| .|......|.....||| .|:. |.|:....|||.|||.::.|..|:..:|
Frog  1611 KKMYFIQHGVVSILTRGSKETKLSDGSYFGE-ICLL-TRGRRTASVRADTYCRLYSLSVDNFNEV 1673

  Fly   756 LDSYPEFLESFVSNLVITYNMRDDEHSGVDIKHRYLRAKSSDKMRSSPDIPSIRIVGLRYKKQNV 820
            |:.||....:|             |...:|...|..:..|               :.||.:.:|.
Frog  1674 LEEYPMMRRAF-------------ETVAMDRLDRIGKKNS---------------ILLRKRAENS 1710

  Fly   821 NTSVHK------VKNDNSRDLNI 837
            :.||:.      ||:|.....||
Frog  1711 SGSVNNEIIQQIVKHDRDTAHNI 1733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	64/248 (26%)
		Ion_trans_2	<526..580	CDD:285168	15/53 (28%)
		CAP_ED	657..767	CDD:237999	35/110 (32%)
		Crp	666..>766	CDD:223736	32/100 (32%)
hcn4	XP_002944030.2	Plasmodium_HRP	<67..248	CDD:253181
		Ion_trans_N	1197..1239	CDD:285597	8/43 (19%)
		Ion_trans	1259..1506	CDD:278921	68/273 (25%)
		Crp	1570..>1708	CDD:223736	43/167 (26%)
		CAP_ED	1576..1684	CDD:237999	35/109 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910