DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and cngb1

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_031757189.1	Gene:	cngb1 / 100496200	XenbaseID:	XB-GENE-980342	Length:	1922	Species:	Xenopus tropicalis

Alignment Length:	767	Identity:	144/767 - (18%)
Similarity:	269/767 - (35%)	Gaps:	230/767 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KPPVKEFKR--------NCPAKSNKFV--ERELFSLMCNLNKIEKKQVF---VSDILINASMFDD 89
            :||....|.        :.||||.|..  :.::...|.:... |.::|.   .|.|..::::..:
Frog  1203 RPPPSPCKHRTLTVPVTSLPAKSRKRTQSQEDIMEEMSDAAP-EDEEVMERSASAISHSSAIITE 1266

  Fly    90 KKESLARFPKNVSDHNTLVYHKFLRTRPTNDDEALKLKAGGKSKERPGTKITADCFFSPLLFKIN 154
            :.:.|.|..|   |....|..|.:....:::||:.......||...|
Frog  1267 RLQELVRMFK---DRTERVKEKLIDPELSSEDESPSASPSKKSAPPP------------------ 1310

  Fly   155 NKRECLKKVKPMKGENAVETNGIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRE---- 215
                                   |....|::.||                   .:|.|:.|
Frog  1311 -----------------------PPPPPPAEEKK-------------------VEVEAQAEEEHY 1333

  Fly   216 CDLLCSYDPLRKNNADLFQTHKGTSYECMFKNLKYNQAEKPTDNVMGNSYDDMLDKEALLGSKSE 280
            |::||                      |.||...:                    ::.||..|.
Frog  1334 CEMLC----------------------CKFKTRPW--------------------RDRLLKLKF- 1355

  Fly   281 PKGQDPNDMITSLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFL 345
            |...||                |.|..|..|...    ....|:|...::        |...||
Frog  1356 PSSIDP----------------LTNVMYVLWLFF----VVLAWNWNCWLI--------PVRWAF- 1391

  Fly   346 LGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDI-IINFRTTFVNSQDEVVSHPGRIAVHYL-SG 408
                .||..:    |....:::|.:.|:.:::|| :...|..||...| ::::...:..||. |.
Frog  1392 ----PYQTPS----NIHYWLLMDYLCDLIYLLDITVFQSRLQFVRGGD-IITNKKDMREHYFKSE 1447

  Fly   409 WFLIDLVAAVPFDLLLVGSDTDETTTLIGLLK--TARLLRLVRVARKIDRYSEYGAAVLILLMAT 471
            .|.:||::.:|.|||              .||  ...||||.|:. |...:.|:...:..:|...
Frog  1448 RFKMDLISLLPLDLL--------------YLKFGVKSLLRLPRIL-KYMAFFEFNNRLEAILSKA 1497

  Fly   472 FI-----------LIAHWLACIWYAIGNAEKSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSR 525
            :|           ...|..||::|...:.|   ...:..|:           ||      .:.:.
Frog  1498 YIYRVIRTTAYLLYCLHMNACLYYWASDYE---GLSSTPWV-----------FD------GVGNS 1542

  Fly   526 YITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHT 590
            ||...|:...:|.::| |...|:|..|..|.:....:|...::.:.|.:..::....:|...|.:
Frog  1543 YIRCYYWAVKTLITIG-GLPDPDTLFELWFQLLNYFMGVFAFSVMIGQMRDVVGAATAGQTYYRS 1606

  Fly   591 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHLNRKLLTTC 655
            .|....:::..::||..::.|::.::::.|.....:|.:.|:...|:.::.|:.:.:|..:::..
Frog  1607 CMDSTIKYMNCYKIPRSVQNRVKMWYEYTWQSQGMLDESELMVQLPDKMRLDLAIDVNYSIVSKV 1671

  Fly   656 AAFSEASPGCLRAFSL----KFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGN----IVV 712
            ..|.    ||.|....    :.::....|||.:..:|::...:|.|..|.:::....:    :|.
Frog  1672 ILFQ----GCDRQMIYDMLKRLRSVVYLPGDYVCKKGEIGREMYIIKAGQVQVLGGPDGKTVLVS 1732

  Fly   713 LGKNDIFGENPCIYPTVGKSN---GVVRALTYCDIHKLHRDDLLDVLDSYPE 761
            |....:|||...:  .||..|   ..|.|..:.::..|.:.||.::|..|||
Frog  1733 LKAGSVFGEISLL--AVGGGNRRTANVVAHGFTNLFILDKKDLNEILLHYPE 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	50/237 (21%)
		Ion_trans_2	<526..580	CDD:285168	12/53 (23%)
		CAP_ED	657..767	CDD:237999	28/116 (24%)
		Crp	666..>766	CDD:223736	25/107 (23%)
cngb1	XP_031757189.1	PTZ00121	<507..1098	CDD:173412
		PLN03192	1359..>1745	CDD:215625	91/463 (20%)
		CAP_ED	1673..1782	CDD:237999	26/114 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000