Protein Alignment sei and HCN4

DIOPT Version :9

• Sequence 1: NP_001286814.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_005468.1
• Gene: HCN4 / 10021
• HGNCID: 16882
• Length: 1203
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 137/528 - (25%)
• Similarity: 237/528 - (44%)
• Gaps: 101/528 - (19%)

  Fly   311 WTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTF 375
            |.:..||.|:..||..:|:|::...|..|....|...|           |:.|.::.:::.|..|
Human   253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDE-----------NTTPWIVFNVVSDTFF 306

  Fly   376 IVDIIINFRT-TFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLL------VGSDTDET- 432
            ::|:::|||| ..|....|::..|.||.:.||..||::|.::::|.|.:.      :.|:..:|
Human   307 LIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTA 371

  Fly   433 --------TTLIGLLKTARLLRLVRVARKIDRYSE-------YGAAV--LILLMATFILIAHWLA 480
                    |.::.||   |||||.|:.|.|.::.|       ..:||  ::.|:...:|:.||..
Human   372 RALRIVRFTKILSLL---RLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDG 433

  Fly   481 CI--------------WYAIGNAEKSIASKNIGWLNSLAYDIQEPYFDNRTGGPSIKSRYITALY 531
            |:              |.:|.|      ..|..|....:|                      ||:
Human   434 CLQFLVPMLQDFPDDCWVSINN------MVNNSWGKQYSY----------------------ALF 470

  Fly   532 FTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVR 596
            ...:.:..:|:|..||...::...|:..|:||:..||...|:.:|:||.|.|...:|..:..:|.
Human   471 KAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVE 535

  Fly   597 EFIRFHQIPNPLRQRLEEYFQHAWTYTNG--IDMNSLLKGFPECLQADICLHLNRKLLTTCAAFS 659
            :::.||::|...|||:.:|::|.:   .|  .|..|:|....|.|:.:|.....|||:.:...|:
Human   536 QYMSFHKLPPDTRQRIHDYYEHRY---QGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFA 597

  Fly   660 EASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGN-IVVLGKNDIFGENP 723
            .|.|..:.:...|.:.....|||.::..|.:...:|||..|.:.:...|| ...|.....||| .
Human   598 NADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE-I 661

  Fly   724 CIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVS------------NLVITYNM 776
            |:. |.|:....|||.|||.::.|..|:..:||:.||....:|.:            |.::.:.:
Human   662 CLL-TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKV 725

  Fly   777 RDDEHSGV 784
            :.|.:|||
Human   726 QHDLNSGV 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	65/261 (25%)
		Ion_trans_2	<526..580	CDD:285168	15/53 (28%)
		CAP_ED	657..767	CDD:237999	33/110 (30%)
		Crp	666..>766	CDD:223736	30/100 (30%)
HCN4	NP_005468.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..182
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		2/6 (33%)
		Ion_trans_N	218..260	CDD:285597	2/6 (33%)
		Ion_trans	280..525	CDD:278921	69/286 (24%)
		Crp	589..>724	CDD:223736	36/136 (26%)
		CAP_ED	595..703	CDD:237999	33/109 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..856
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..897
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..1203

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740