DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sei and kcnh8

DIOPT Version :9

Sequence 1:	NP_001286814.1	Gene:	sei / 37843	FlyBaseID:	FBgn0003353	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_017207899.2	Gene:	kcnh8 / 100002967	ZFINID:	ZDB-GENE-060503-204	Length:	975	Species:	Danio rerio

Alignment Length:	683	Identity:	257/683 - (37%)
Similarity:	389/683 - (56%)	Gaps:	96/683 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LFQTHKGTSYECMFKNLKYNQAEKPTDNVMGN------SYDDMLDKEA--LLGSKSEP------K 282
            :|....|:.:.|:...:       |..|..|:      |:.|:.|.:|  .|..|.|.      |
Zfish    94 MFYKKSGSVFWCLLDIV-------PIKNEKGDVVLFLASFKDVTDTKAKSTLEEKKEECRREKVK 151

  Fly   283 GQDP--------NDMITSLGGNILLDQ-----KLQNNYY----------------HKWTLLHYSP 318
            |..|        :.::..:.|::...|     ||..|.:                .|:.|||:|.
Zfish   152 GDSPFGSTRLRSSTVLYHISGHLHNRQKQSKIKLNKNVFGDPPALPEYKVADAKKSKFILLHFST 216

  Fly   319 FKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDLIVDVTFIVDIIINF 383
            |||.|||:||:...|.|:..||...| :|:||..|..:         :.|:.|::.||:||:.:|
Zfish   217 FKAGWDWLILLATFYVAVTVPYNVCF-IGDQDLTRSTT---------VTDIAVEILFIIDIVFSF 271

  Fly   384 RTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLV 448
            |||:|:...:|:....:|.:||::.||:||||||:|||||.....:  ..:::.||||.|||||:
Zfish   272 RTTYVSKSGQVIFDARQICIHYMTTWFIIDLVAALPFDLLYAFKVS--VVSVVHLLKTVRLLRLL 334

  Fly   449 RVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIG--NAEKSIASKNIGWLNSLAYDIQEP 511
            |:.:|:||||::...||.|||:.|.|:|||:|||||.||  ..|.:..:.:||||:.|...::.|
Zfish   335 RLLQKMDRYSQHSTVVLTLLMSMFALLAHWMACIWYIIGKKEVESNADTWDIGWLHELGKRLESP 399

  Fly   512 Y--FDNRT--GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFG 572
            |  ..|||  .|||::|.||.|||||.:||||||||||:.||||||.|:||.||:|:||:|.:||
Zfish   400 YEGVANRTLSSGPSLRSIYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFG 464

  Fly   573 NVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPE 637
            ||:|||||:||..:.|||:...:::|||.|.:|..|:||:.||||..|:..||||.|.||:.||:
Zfish   465 NVTAIIQRMYSRWSSYHTRTKDLKDFIRVHHLPQSLKQRMLEYFQTTWSVNNGIDSNELLRDFPD 529

  Fly   638 CLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSI 702
            .|::||.:|||:::| ..:.||..|.||||:.||..||:...||:.|:.:||.|.:|:|:..||:
Zfish   530 ELRSDIAMHLNKEIL-ELSVFSSLSRGCLRSLSLHIKTSFCAPGEYLLRQGDALQALFFVCSGSM 593

  Fly   703 EIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESF 766
            |:.:...:: :|||.|:.|.|..:...|.|:|..|:||||||:..::...|.:|||.|||:...|
Zfish   594 EVLKDNMVLAILGKGDLIGANMSVGDRVIKTNADVKALTYCDLQCINLRGLYEVLDLYPEYSHRF 658

  Fly   767 VSNLV--ITYNMRDDEHSGVDIKHRYLRAKSSD-KMRSSPDIPSIRIV----------------- 811
            |.::.  :|||:|:.:.|.|..:   :.:||.| :|....:..:|:..
Zfish   659 VQDITHDLTYNLREGQESHVISR---MSSKSMDTQMEGRGNGDAIQCYPPIAEHHNEEDDDDDDD 720

  Fly   812 ---GLRYKKQNVNTSVHKVKNDNSRDLNIFIEN 841
               .::|.........|..|||:..:..:.|::
Zfish   721 EDDQIQYLSGGGKQKTHMQKNDHQTNKKLHIQH 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sei	NP_001286814.1	Ion_trans	360..583	CDD:278921	116/228 (51%)
		Ion_trans_2	<526..580	CDD:285168	39/53 (74%)
		CAP_ED	657..767	CDD:237999	45/110 (41%)
		Crp	666..>766	CDD:223736	40/100 (40%)
kcnh8	XP_017207899.2	PAS_9	36..131	CDD:315989	8/43 (19%)
kcnh8	XP_017207899.2	Ank_2	193..>620	CDD:330894	200/439 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740