DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaSnap1 and NAPG

DIOPT Version :9

Sequence 1:	NP_477469.1	Gene:	gammaSnap1 / 37842	FlyBaseID:	FBgn0028552	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	XP_011524056.1	Gene:	NAPG / 8774	HGNCID:	7642	Length:	372	Species:	Homo sapiens

Alignment Length:	310	Identity:	118/310 - (38%)
Similarity:	186/310 - (60%)	Gaps:	20/310 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IAEAEDLVKQAEKSLKLSMLKWVPDYDSAADEYSKAATAYRIAKSYDKSKECFLKAIDAYKNNKS 73
            |...|..||:. .|||...|||.|||||||.||.|||.|::.||.::::|:..|:...|::||::
Human    67 IDSLEKKVKRT-NSLKTGFLKWKPDYDSAASEYGKAAVAFKNAKQFEQAKDACLREAVAHENNRA 130

  Fly    74 WFHAAKAYEQIILLSKDADKLHEVEEYANKSASLYQQHGSPEAAASALDKAAKLTESKHPDMALR 138
            .|||||||||..::.|:..||.|..:...|::.:|.::|:|:.||.||::|.||.|:..|:.|::
Human   131 LFHAAKAYEQAGMMLKEMQKLPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENVDPEKAVQ 195

  Fly   139 FYQHALEVIMIEDSVRQAAEYASKVSRILVKLRRYDEATNALKKEISLNQQTESYGQIGRLVVAL 203
            .||....|...|:.:|||.|...|.||:||:.||:|||..:::||.::.::.|:|....:..:|.
Human   196 LYQQTANVFENEERLRQAVELLGKASRLLVRGRRFDEAALSIQKEKNIYKEIENYPTCYKKTIAQ 260

  Fly   204 VMVQLARGDSVEAEKTFREWGNCCEP-----EEVSTLQTLLQAFDDEDPELAARMLASPFIRHMD 263
            |:|.|.|.|.|.||:..||  :...|     |:.:.|:.||:.:|.:|.:..:.:..||..::||
Human   261 VLVHLHRNDYVAAERCVRE--SYSIPGFNGSEDCAALEQLLEGYDQQDQDQVSDVCNSPLFKYMD 323

  Fly   264 VEYAILSKNIPLPQGIQMEKKA---------GDTAAETNDAEDE--GGLC 302
            .:||.|..::.:|.| .::||:         |.||...::.|||  ||||
Human   324 NDYAKLGLSLVVPGG-GIKKKSPATPQAKPDGVTATAADEEEDEYSGGLC 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaSnap1	NP_477469.1	SNAP	11..248	CDD:305195	96/241 (40%)
		TPR repeat	33..70	CDD:276937	17/36 (47%)
		TPR repeat	74..111	CDD:276937	15/36 (42%)
		TPR repeat	114..149	CDD:276937	14/34 (41%)
		TPR repeat	153..187	CDD:276937	16/33 (48%)
NAPG	XP_011524056.1	SNAP	71..338	CDD:276937	104/269 (39%)
		TPR repeat	90..127	CDD:276937	17/36 (47%)
		TPR repeat	131..168	CDD:276937	15/36 (42%)
		TPR repeat	171..206	CDD:276937	14/34 (41%)
		TPR repeat	210..246	CDD:276937	16/35 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159302
Domainoid	1	1.000	180	1.000	Domainoid score	I3515
eggNOG	1	0.900	-	-		E1_KOG1585
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2838
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3662
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55184
OrthoDB	1	1.010	-	-		D1540214at2759
OrthoFinder	1	1.000	-	-		FOG0003744
OrthoInspector	1	1.000	-	-		otm40472
orthoMCL	1	0.900	-	-		OOG6_103437
Panther	1	1.100	-	-	LDO	PTHR13768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4330
SonicParanoid	1	1.000	-	-		X4180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800