DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaSnap1 and napga

DIOPT Version :9

Sequence 1:	NP_477469.1	Gene:	gammaSnap1 / 37842	FlyBaseID:	FBgn0028552	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001013498.2	Gene:	napga / 541353	ZFINID:	ZDB-GENE-050320-46	Length:	308	Species:	Danio rerio

Alignment Length:	311	Identity:	124/311 - (39%)
Similarity:	195/311 - (62%)	Gaps:	18/311 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKKIAEAEDLVKQAEKSLKLSMLKWVPDYDSAADEYSKAATAYRIAKSYDKSKECFLKAIDAYKN 70
            |:||:||.:.:.:|||.||.|.:||.|||||||.||:|||.|::.||..:::|:.:|:..:|:.|
Zfish     2 AQKISEAHEHIAKAEKYLKTSFMKWKPDYDSAASEYAKAAVAFKNAKQLEQAKDAYLQEAEAHAN 66

  Fly    71 NKSWFHAAKAYEQIILLSKDADKLHEVEEYANKSASLYQQHGSPEAAASALDKAAKLTESKHPDM 135
            |:|.||||||:||..::.||..::.|..:|..|::.:|.::|:|:.||.|||:|.||.|......
Zfish    67 NRSLFHAAKAFEQAGMMLKDLQRMPEAVQYIEKASVMYVENGTPDTAAMALDRAGKLMEPLDLSK 131

  Fly   136 ALRFYQHALEVIMIEDSVRQAAEYASKVSRILVKLRRYDEATNALKKEISLNQQTESYGQIGRLV 200
            |:..||.|..|...|:.:|||||...|.||:||:.:::|||..:|:||.|:.::.|:|....:..
Zfish   132 AVHLYQQAAAVFENEERLRQAAELIGKASRLLVRQQKFDEAAASLQKEKSMYKEMENYPTCYKKC 196

  Fly   201 VALVMVQLARGDSVEAEKTFRE-------WGNCCEPEEVSTLQTLLQAFDDEDPELAARMLASPF 258
            :|.|:|||.|.|.|.|:|..||       .|:    |:.:.|:.||||:|::|.|...|:..||.
Zfish   197 IAQVLVQLHRADYVAAQKCVRESYSIPGFSGS----EDCAALEDLLQAYDEQDEEQLLRVCRSPL 257

  Fly   259 IRHMDVEYAILSKNIPLP----QGIQMEKKAGDTAAETNDAEDE---GGLC 302
            :.:||.:||.|:.::.:|    .|...:|.:...:|:..:.||:   ||||
Zfish   258 VTYMDNDYAKLAISLKVPGGGGGGGGKKKPSASASAQPQEEEDDEYAGGLC 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaSnap1	NP_477469.1	SNAP	11..248	CDD:305195	102/243 (42%)
		TPR repeat	33..70	CDD:276937	17/36 (47%)
		TPR repeat	74..111	CDD:276937	14/36 (39%)
		TPR repeat	114..149	CDD:276937	15/34 (44%)
		TPR repeat	153..187	CDD:276937	17/33 (52%)
napga	NP_001013498.2	SNAP	7..275	CDD:276937	111/271 (41%)
		TPR repeat	29..66	CDD:276937	17/36 (47%)
		TPR repeat	70..107	CDD:276937	14/36 (39%)
		TPR repeat	110..145	CDD:276937	15/34 (44%)
		TPR repeat	149..185	CDD:276937	17/35 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595433
Domainoid	1	1.000	193	1.000	Domainoid score	I3143
eggNOG	1	0.900	-	-		E1_KOG1585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3493
OMA	1	1.010	-	-		QHG55184
OrthoDB	1	1.010	-	-		D1540214at2759
OrthoFinder	1	1.000	-	-		FOG0003744
OrthoInspector	1	1.000	-	-		mtm6409
orthoMCL	1	0.900	-	-		OOG6_103437
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4330
SonicParanoid	1	1.000	-	-		X4180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800