DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaSnap1 and Napg

DIOPT Version :9

Sequence 1:	NP_477469.1	Gene:	gammaSnap1 / 37842	FlyBaseID:	FBgn0028552	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	XP_011245108.1	Gene:	Napg / 108123	MGIID:	104561	Length:	362	Species:	Mus musculus

Alignment Length:	365	Identity:	122/365 - (33%)
Similarity:	194/365 - (53%)	Gaps:	69/365 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAAKKIAEAEDLVKQAEKSLKLSMLKWVPDYDSAADEYSKAATAYRIAKSYDKSKECFLKAIDAY 68
            :||:||.|..:.:.:|||.||...|||.|||||||.||.|||.|::.||.::::|:..|:...|:
Mouse     1 MAAQKINEGLEHLAKAEKYLKTGFLKWKPDYDSAASEYGKAAVAFKNAKQFEQAKDACLREAVAH 65

  Fly    69 KNNKSWFHAAKAYEQIILLSKDADKLHEVEEYANKSASLYQQHGSPEAAASALDKAAKLTESKHP 133
            :||::.|||||||||..::.|:..||.|..:...|::.:|.::|:|:.||.||::|.||.|:..|
Mouse    66 ENNRALFHAAKAYEQAGMMLKEMQKLPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENVDP 130

  Fly   134 DMALRFYQHALEVIMIEDSVRQAAEYASKVSRILVKLRRYDEATNALKKEISLNQQTESY----- 193
            :.|::.||....|...|:.:|||.|...|.||:||:.||:|||..:::||.::.::.|:|
Mouse   131 EKAVQLYQQTANVFENEERLRQAVELLGKASRLLVRGRRFDEAALSIQKEKNIYKEIENYPTCYK 195

  Fly   194 ---------------------------GQ-------------IG-----RLVVALVMVQLARGDS 213
                                       |:             :|     :..:|.|:|.|.|.|.
Mouse   196 VEFWSPAERTGTGTKRTGTDPREEEHLGKGNPLCVWPTQILAVGTWDRPKKTIAQVLVHLHRNDY 260

  Fly   214 VEAEKTFREWGNCCEP-----EEVSTLQTLLQAFDDEDPELAARMLASPFIRHMDVEYAILSKNI 273
            |.||:..||  :...|     |:.:.|:.||:.:|.:|.:..:.:..||..::||.:||.|..::
Mouse   261 VAAERCVRE--SYSIPGFNGSEDCAALEQLLEGYDQQDQDQVSEVCNSPLFKYMDNDYAKLGLSL 323

  Fly   274 PLPQGIQMEKK-----------AGDTAAETNDAEDEGGLC 302
            .:|.| .::||           |...|||..:.|..||||
Mouse   324 VVPGG-GIKKKSPATPQAKPDGAAGMAAEEEEDEYSGGLC 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaSnap1	NP_477469.1	SNAP	11..248	CDD:305195	98/291 (34%)
		TPR repeat	33..70	CDD:276937	17/36 (47%)
		TPR repeat	74..111	CDD:276937	15/36 (42%)
		TPR repeat	114..149	CDD:276937	14/34 (41%)
		TPR repeat	153..187	CDD:276937	16/33 (48%)
Napg	XP_011245108.1	SNAP	8..328	CDD:276937	106/321 (33%)
		TPR repeat	30..67	CDD:276937	17/36 (47%)
		TPR repeat	71..108	CDD:276937	15/36 (42%)
		TPR repeat	111..146	CDD:276937	14/34 (41%)
		TPR repeat	150..186	CDD:276937	16/35 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849672
Domainoid	1	1.000	180	1.000	Domainoid score	I3488
eggNOG	1	0.900	-	-		E1_KOG1585
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2838
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3645
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55184
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003744
OrthoInspector	1	1.000	-	-		otm42549
orthoMCL	1	0.900	-	-		OOG6_103437
Panther	1	1.100	-	-	LDO	PTHR13768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4330
SonicParanoid	1	1.000	-	-		X4180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790