Protein Alignment tsr and CFL2

DIOPT Version :10

• Sequence 1: NP_477034.1
• Gene: tsr / 37841
• FlyBaseID: FBgn0011726
• Length: 148
• Species: Drosophila melanogaster
• Sequence 2: NP_068733.1
• Gene: CFL2 / 1073
• HGNCID: 1875
• Length: 166
• Species: Homo sapiens
• Alignment Length: 168
• Identity: 63/168 - (37%)
• Similarity: 85/168 - (50%)
• Gaps: 41/168 - (24%)

  Fly     1 MASGVTVSD-VCK----------TTYEEIKKDKKHRYVIFYIRDEK-QIDVE------------T 41
            |||||||:| |.|          :|.|||||.||  .|:|.:.|:| ||.||            |
Human     1 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKK--AVLFCLSDDKRQIIVEEAKQILVGDIGDT 63

  Fly    42 VADRNAEYDQFLEDIQKCGP-GECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKM 105
            |.|   .|..|:    |..| .:|||.|:|..|      .::.|||:.|..:.|.|::|.:|.||
Human    64 VED---PYTSFV----KLLPLNDCRYALYDATY------ETKESKKEDLVFIFWAPESAPLKSKM 115

  Fly   106 LYSSSFDALKKSLVGVQKYIQATDLSE-ASREAVEEKL 142
            :|:||.||:||...|::...|...|.: ..|..:.|||
Human   116 IYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKL 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tsr	NP_477034.1	ADF_cofilin_like	3..142	CDD:200442	59/164 (36%)
CFL2	NP_068733.1	Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	2..55		25/54 (46%)
		ADF_cofilin_like	3..153	CDD:200442	59/164 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	30..34		2/3 (67%)
		Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	55..105		17/62 (27%)