Protein Alignment tsr and CFL1

DIOPT Version :10

• Sequence 1: NP_477034.1
• Gene: tsr / 37841
• FlyBaseID: FBgn0011726
• Length: 148
• Species: Drosophila melanogaster
• Sequence 2: NP_005498.1
• Gene: CFL1 / 1072
• HGNCID: 1874
• Length: 166
• Species: Homo sapiens
• Alignment Length: 167
• Identity: 61/167 - (36%)
• Similarity: 85/167 - (50%)
• Gaps: 39/167 - (23%)

  Fly     1 MASGVTVSD-VCK----------TTYEEIKKDKKHRYVIFYI-RDEKQIDVE------------T 41
            |||||.||| |.|          :|.||:||.||  .|:|.: .|:|.|.:|            |
Human     1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKK--AVLFCLSEDKKNIILEEGKEILVGDVGQT 63

  Fly    42 VADRNAEYDQFLEDIQKCGPGECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKML 106
            |.|..|.:.:.|.|      .:|||.|:|..|      .::.|||:.|..:.|.|::|.:|.||:
Human    64 VDDPYATFVKMLPD------KDCRYALYDATY------ETKESKKEDLVFIFWAPESAPLKSKMI 116

  Fly   107 YSSSFDALKKSLVGVQKYIQATDLSEA-SREAVEEKL 142
            |:||.||:||.|.|::..:||....|. .|..:.|||
Human   117 YASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKL 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tsr	NP_477034.1	ADF_cofilin_like	3..142	CDD:200442	57/163 (35%)
CFL1	NP_005498.1	ADF_cofilin_like	3..153	CDD:200442	57/163 (35%)
		Nuclear localization signal. /evidence=ECO:0000255	30..34		2/3 (67%)