DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IntS1 and Ints1

DIOPT Version :9

Sequence 1:NP_611875.1 Gene:IntS1 / 37840 FlyBaseID:FBgn0034964 Length:2053 Species:Drosophila melanogaster
Sequence 2:XP_006504790.1 Gene:Ints1 / 68510 MGIID:1915760 Length:2226 Species:Mus musculus


Alignment Length:2289 Identity:712/2289 - (31%)
Similarity:1133/2289 - (49%) Gaps:338/2289 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDRGKGSGSNR-SQKKVPLG----GELFALG-KSVRDDSKSKILPIKGMSS---SDRKREASTAL 56
            |:|.|.:...| |....|.|    |:..||| |....:||:....:|...|   |:|||:||.:|
Mouse    28 MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQASESKTTSTLLKPAPSGLPSERKRDASASL 92

  Fly    57 ASSS------KRFR----------GNLKDAGAPDMSSGSSQCETWEQFAVDCD-LDTVV--ETIY 102
            :.:|      ||.:          |.|.:|...:..:.|...:  |...|..: |.||:  |...
Mouse    93 SGTSALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIK--EPSVVPIEVLPTVLLDEIEA 155

  Fly   103 AALEQNDSETVGRLVCGVIKQTTTSSSRSKVDNIALLALIYVAKVQPSIFCTDIVACALLSFLRR 167
            |.||.||....| ::||.:||...  :|:|.|:...|:|:|:||::|:||.|:.|..||.|.|||
Mouse   156 AELEGNDDRIEG-VLCGAVKQLKV--TRAKPDSTLYLSLMYLAKIKPNIFATEGVIEALCSLLRR 217

  Fly   168 EA--NVKMRYNTNLHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICA 230
            :|  |.|.:.|:.:.:|..|||...:.|...|||:.:::||:|::.||.|.|:..|...|.||..
Mouse   218 DASVNFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCRTFVDNIQT 282

  Fly   231 AFKTRTPHIS-LLRWDVSSS---LPSGQAHRDSMTVDDDSGDNSTQSLDASPLNTESEPIPDAMC 291
            ||.|:.|..| ||:.:.:.|   |.:|.:...|:|.::||   .|:.|.|   ..:..|..:...
Mouse   283 AFNTKMPPKSVLLQGEGARSGGELGAGSSPHPSLTEEEDS---QTELLIA---EEKLSPEQEGQL 341

  Fly   292 TTKSRFSDAV--VQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWIHN 354
            ..:.|:.:..  |:::|.|.:|||||:||..||.:||.|:.|..|.|..|||.|::.|||:|:.|
Mouse   342 MPRPRYDELTESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTATCGYKEVRLLAVQRLEMWLQN 406

  Fly   355 GKLVKFAQQLLSYICFNIKGRNTQDNEVLLVLVKMRLKTKPLINHYMSCLKEMIFLQPEILSTVM 419
            .||.:.||.||..:|.|.....::|.:|:..|:|:|||.|.|:||||.|::|::....:.|.|.:
Mouse   407 PKLTRPAQDLLMSVCMNCNSHGSEDMDVISHLIKIRLKPKVLLNHYMLCIRELLNAHKDNLGTTI 471

  Fly   420 KLVVQNELSNTRNPNNMGMLATMFQTSADQSAATLAEIYQEFLLQRDDCLRTLRVFLRELVRMLR 484
            |.|:.|||||.||||||.:|.|:.|.|::.:...||.::|:.|..:||.||..|..|||:::..:
Mouse   472 KFVIFNELSNARNPNNMQILYTVLQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTK 536

  Fly   485 FDVNLVKFCKTFLSEREDLTPQIEMFEFKERIFNSMVDIVCLCMFLSATPQAREASLSLKTNRDT 549
            .::|...||...:.||::  ||....|||||....:.|::.:.|.|..|.|.:||.::  .::..
Mouse   537 HEINFQAFCLGLMQERKE--PQYLEMEFKERFVVHITDVLAVSMMLGITAQVKEAGVA--WDKGE 597

  Fly   550 KNNHALLKLY-NQMSQIQLDTVSWMYETVPTLFKIPAAEYHQALHKLLLLDSPEQYSRCDQWPSE 613
            |.|..:|:.: ||::.||.|.|.|::..||::.|:...:|...|||:|..:.||.|.:.|.||.|
Mouse   598 KRNLEVLRTFQNQIAAIQRDAVWWLHTVVPSVSKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPE 662

  Fly   614 PERGAILRIISETPIHEETLLRIILIGITKDIPFSIANTFDVLLLVIKRVSGMKATNIPAVQANK 678
            .:|...||:.||.||.|:||:|:::||:::::|...|:..::...::||.:.::|.::..::..:
Mouse   663 SDRNFFLRLCSEVPILEDTLMRVLVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVER 727

  Fly   679 FDIIDFLFSMSEYHHPENIRLPAEYEPPKLAIIAFYWKAWLILLMISAHNPSSFGAFCWDHYPTM 743
            ..:||.:.::..|||||||:||..|:||.|||...|||||.:||:::|.||.:.|...|:.|||:
Mouse   728 IQLIDAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTL 792

  Fly   744 KMMMEICITNQFNNSSAT-----------KDELQIITMERDHILQFETYLAAQTSPHAVITEETA 797
            ||:||:.:||.::....|           ..||||...|:..||.||.:||| .|....|||.::
Mouse   793 KMLMEMVMTNNYSYPPCTLTDEETRTEMINRELQISQREKQEILAFEGHLAA-ASTKQTITESSS 856

  Fly   798 ILITQLMLMDPMGTPRKVPSMVLDQLKFLNQTYKLGHLFCRCRKPDLLLDIIQRQGTTQSMPWLS 862
            :|::||..:||.|.||:.|..:|||:|.|||:.:||||.||.|.||.||.|||||.::||||||:
Mouse   857 LLLSQLTSLDPQGPPRRPPPHILDQVKALNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLA 921

  Fly   863 DLVQNSEGDFSHLPVQCLCEFLLFNAHIINEENSRDAE-------------------LVNFLRNL 908
            ||||:|||....|||||||||||.:|.........|.|                   |:..|::|
Mouse   922 DLVQSSEGSLDVLPVQCLCEFLLHDAADSTASGEEDDEGESREQKAKKRQRQQKQRQLLGRLQDL 986

  Fly   909 IFDGNLSHQIVCELLDYIFRRLSSTVKQSRVAALSGLKIIFRHSG--DFEN-------------- 957
            :.......|..||:|||..|||.|:...|||.|:.||.::....|  |.|.              
Mouse   987 LLGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGGLRDKEEKEPPMEEDIGETDA 1051

  Fly   958 ----EWLLKSLQQIPHFYEVKPFIIPQLRAACQVENCPELIMAYIQFITAHTLNDPVNEMLDH-- 1016
                :|||:.|.::|.|..|:......|:.|..:|..|:.|.||:.:::.||   ||.|...|  
Mouse  1052 LQGYQWLLRDLPRLPLFDSVRTTTALALQQAIHMETDPQTISAYLIYLSQHT---PVEEQGPHSD 1113

  Fly  1017 -VIDMAQLIVERSTMFQHIIISQEDYDYVPDENRIQTLKCLFVMFNNYIIKLR---EYHEPYEWT 1077
             .:|:|:|:|||||:..| :.|:.......|    ..|..|..:|:.|:.::|   |..|.|.|:
Mouse  1114 LALDVARLVVERSTIMAH-LFSKPSCSTASD----AVLSALLSVFSRYVRRMRKSKEGEEVYSWS 1173

  Fly  1078 EYPDLLMVQFDDGVQLPLHINIIHAFIILLTYS--NSNMPESIPILDYWFPPGRPAPVAFLPSMP 1140
            |..|.:.:::..|....:||.::||.:||||..  .|...|...:||.|||..:|.|.|||....
Mouse  1174 ESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRSGDSEFSELLDIWFPEKKPLPTAFLVDTS 1238

  Fly  1141 QEQVQLLPDWLKLKMIRSSVDRLIEAALNDLTPDQIVLFVQNFGTPVNSMSKLLAMLDTAVLEQF 1205
            :|.: ||||||||:||||.|.||::|||.||.|.|::||||:||.||:||||||..||.||.:..
Mouse  1239 EEAL-LLPDWLKLRMIRSEVPRLVDAALQDLEPQQLLLFVQSFGIPVSSMSKLLQYLDQAVAQDP 1302

  Fly  1206 DLVKNAILNKAYLAQLIEIQQARGAKNGHYTVQALDLHSHSQTVPDLPKISVVIQEAVEIDDYDS 1270
            ..::..|::|.|:|.|:|:|..|||..|.        ..||.....||.    .:::.|....:|
Mouse  1303 QTLEQNIMDKNYMAHLVEVQHERGASGGQ--------TFHSLLTASLPP----RRDSTEAPKPES 1355

  Fly  1271 S--------------------DSDDRPTNFLATKEVAQTILTQPD---QLTESRSDCRSLIQKLL 1312
            |                    ..||....||      |.....||   |.:..|....:|.|.|.
Mouse  1356 SPEPPPGQGRTRAGTQVPVLGPEDDLAGIFL------QIFPLSPDPRWQSSSPRPLALALQQALG 1414

  Fly  1313 DMLASPNSNRADV-------VNAITEVLAV--GCSVTMSRH-----ACTFLR------------T 1351
            ..||.......:|       :.|:|.:|:.  |.::.::.|     :|..:|            |
Mouse  1415 QELARVRQGNPEVPGITVRLLQAMTTLLSSPHGGTLALAMHHSHFLSCPLMRQLYQYQRAVPQDT 1479

  Fly  1352 FFSCMLHSDKYHIL---------ENALQKNLSMF------KHTFAD--SSLLQKSEL--YHESLV 1397
            .||.:.......||         :..||..|.:|      :|..:|  |.||..::.  :|..|.
Mouse  1480 GFSSLFLKVLMQILQWLDSPAVEDGPLQAQLKLFATRYSARHRISDVRSGLLHLADALSFHGDLE 1544

  Fly  1398 FMLRNSREIYA-----QQFKANTALVARKRIVRAIVQ------------SFDQTKD--------- 1436
            .....:|.:.|     ::......|::  :::|.:::            .|..|.:         
Mouse  1545 VANSTARAVIATLRSGEKCPVEPELIS--KVLRGLIEVRSPHLEELLTALFSATTETSCPSPASG 1607

  Fly  1437 -------------------SKTVAKSKSDQLFH----NGLFIDWLSEMDPEIV-STQLMKERFLF 1477
                               ||...:..|.:...    :||.:|||..:|||:| |...::.:.||
Mouse  1608 PIVVVSSLLLQEKEELLGPSKQEVEGASTEAMRLGPASGLLVDWLETLDPEVVCSCPDLQWKLLF 1672

  Fly  1478 SK---------SCSEFRFYLLSLINHQTNWDTIE-RIAEYLFKNFHEDYDYATVLNYFEALTTNP 1532
            |:         ....||.|||:|:.||.:|.|:. .|...|.|:..:..|.:..|::..|....|
Mouse  1673 SRRKGKGHISAQVLSFRPYLLALLTHQASWSTLHCCIRVLLGKSREQRLDPSASLDFLWACIHVP 1737

  Fly  1533 KLWKGRDKYMSKNVRPDAFFMLRTSELEPFSHFILHEGLSEVKLDSKNYDFK----LCSRMNLLF 1593
            ::|:|||:...:..|.:....::..||......|    |||.:..|::.|..    :.:|:.||.
Mouse  1738 RIWQGRDQRTPQKRREELVLHVQGPELLSLVELI----LSEAETRSQDGDSAARTLIQTRLPLLL 1798

  Fly  1594 KLTEKRRDLMVKVMEHVEK------SSVSDYLKLQVLQQMYIMYPRIKFLKP-------GKTGEQ 1645
            .......:.:.||.||:..      .||.......:|.|:|:..|.::...|       |.|...
Mouse  1799 SCCRSNDESIGKVTEHLTSCIQQWGDSVLGQRCRDLLLQLYLQRPEVRVPVPEVLLQSEGATSSS 1863

  Fly  1646 AYKLQNLKGCQADKVSNNLITCLGSLVGKKDFETLSTDTELLLRKLAASHPLLFLRQLGVLSSIM 1710
            .        |:.|.:.:..||.|......:..|:...|..:..||||.:||:|.||.|.::::::
Mouse  1864 I--------CKLDGLVHRFITLLADTSDSRSSESRVADANMACRKLAVAHPVLLLRHLPMIAALL 1920

  Fly  1711 QGRAQLSMKALREEHHFHRFVQILRTLELLQPTIFEEAYKNEIQNTLSCYFN-FFKHHSNVKEAC 1774
            .||..|:.:..|:::|...|:.:|..||||||.:|:..::..:.:.|..:.. ...:..:.:...
Mouse  1921 HGRTHLNFQEFRQQNHLAFFLHVLGILELLQPRVFQSEHQGALWDCLRSFIRLLLNYRKSSRHLA 1985

  Fly  1775 QMLNKFVQMLQAYINYNPSSALLFIEQYVGILKELAAKYTSLGKLQVLVQAVALLQHKSHSATEL 1839
            ..::||||.:..|:..:..:|:.|::::...|.:|:...:.|..|:.|:..::|......:...|
Mouse  1986 PFISKFVQFIHKYVGCSAPAAVAFLQKHAEPLHDLSFDNSDLVMLKSLLAGLSLPSRDGRTDQGL 2050

  Fly  1840 DDE-EVKYEYDLDEHFDVKPSASKPVVTEDPIEVNPQTPIDPSSSRGPLSVLTLGSYSRSNYTDI 1903
            |:| |.|       ..|.:.:.|.|:|:     |:..||:                    ...|:
Mouse  2051 DEEGEGK-------QTDERSAGSLPLVS-----VSLSTPL--------------------TVADV 2083

  Fly  1904 SPHFLDLVKIIKQSNTEDVVLGPMQELECLTSKRFVFINELFERLLNLIFSPSAQIRSIAFIILI 1968
            :||    :|.:.:....:.||..:.:::.::.:|...:......|..|:.|.....|::||.:.:
Mouse  2084 APH----MKRLSRGRAVEDVLETLSDIDEMSRRRPEVLGFFSTNLQRLMSSAEESCRNLAFSLAL 2144

  Fly  1969 RHLKHNPGNSDINLCTLNAYIQCLRDENSSVAATAIDNLPEMSVLLQEHAIDILTVAFSLGLKSC 2033
            |.:::||   .|....|..::.||...:..|..||:.||||.::|.||||..:|..||.:|:...
Mouse  2145 RSIQNNP---SIAADFLPTFMYCLGSRDFEVVQTALRNLPEYTLLCQEHAAVLLHRAFLVGVYGQ 2206

  Fly  2034 LNTGHQIRKVLQTL 2047
            ::|..||.:.|:.|
Mouse  2207 IDTSAQISEALKIL 2220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IntS1NP_611875.1 DUF3677 327..407 CDD:289217 35/79 (44%)
Ints1XP_006504790.1 DUF3677 379..459 CDD:372105 35/79 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847720
Domainoid 1 1.000 812 1.000 Domainoid score I68
eggNOG 1 0.900 - - E1_KOG4596
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H53111
Inparanoid 1 1.050 1024 1.000 Inparanoid score I280
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46851
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006612
OrthoInspector 1 1.000 - - oto94441
orthoMCL 1 0.900 - - OOG6_107095
Panther 1 1.100 - - LDO PTHR21224
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3428
SonicParanoid 1 1.000 - - X5610
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.790

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