Protein Alignment IntS1 and Ints1

DIOPT Version :9

• Sequence 1: NP_611875.1
• Gene: IntS1 / 37840
• FlyBaseID: FBgn0034964
• Length: 2053
• Species: Drosophila melanogaster
• Sequence 2: XP_038945895.1
• Gene: Ints1 / 288514
• RGDID: 1308908
• Length: 2225
• Species: Rattus norvegicus
• Alignment Length: 2288
• Identity: 708/2288 - (30%)
• Similarity: 1126/2288 - (49%)
• Gaps: 337/2288 - (14%)

  Fly     1 MDRGKGSGSNR-SQKKVPLG----GELFALG-KSVRDDSKSKILPIKGMSS---SDRKREASTAL 56
            |:|.|.:...| |....|.|    |:..||| |...::||:....:|...|   |:|||:||.:|
  Rat    28 MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRDASASL 92

  Fly    57 ASSS------KRFR----------GNLKDAGAPDMSSGSSQCETWEQFAVDCD-LDTVV--ETIY 102
            :.:|      ||.:          |.|.:|...:..:.|...:  |...|..: |.||:  |...
  Rat    93 SGASGLTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIK--EPSVVPIEVLPTVLLDEIEA 155

  Fly   103 AALEQNDSETVGRLVCGVIKQTTTSSSRSKVDNIALLALIYVAKVQPSIFCTDIVACALLSFLRR 167
            |.||.||....| ::||.:||...  :|:|.|:...|:|:|:||::|:||.|:.|..||.|.|||
  Rat   156 AELEGNDDRIEG-VLCGAVKQLKV--TRAKPDSTLYLSLMYLAKIKPNIFATEGVIEALCSLLRR 217

  Fly   168 EA--NVKMRYNTNLHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICA 230
            :|  |.|.:.|:.:.:|..|||...:.|...|||:.:::||:|::.||.|.|:..|...|.||..
  Rat   218 DASVNFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCRTFVDNIQT 282

  Fly   231 AFKTRTPHIS-LLRWDVSSS---LPSGQAHRDSMTVDDDSGDNSTQSLDASPLNTESEPIPDAMC 291
            ||.|:.|..| ||:.:.:.|   |.:|.:...|:|.::||   .|:.|.|   ..:..|..:...
  Rat   283 AFNTKMPPKSVLLQGEGARSGGELGAGSSPHPSLTEEEDS---QTELLIA---EEKLSPEQEGQL 341

  Fly   292 TTKSRFSDAV--VQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWIHN 354
            ..:.|:.:..  |:::|.|.:|||||:||..||.:||.|:.|..|.|..|||.|::.|||:|:.|
  Rat   342 MPRPRYDELTESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTATCGYKEVRLLAVQRLEMWLQN 406

  Fly   355 GKLVKFAQQLLSYICFNIKGRNTQDNEVLLVLVKMRLKTKPLINHYMSCLKEMIFLQPEILSTVM 419
            .||.:.||.||..:|.|.....::|.:|:..|:|:|||.|.|:||||.|::|::....:.|.|.:
  Rat   407 PKLTRPAQDLLMSVCMNCNSHGSEDMDVISHLIKIRLKPKVLLNHYMLCIRELLNAHKDNLGTTI 471

  Fly   420 KLVVQNELSNTRNPNNMGMLATMFQTSADQSAATLAEIYQEFLLQRDDCLRTLRVFLRELVRMLR 484
            |.|:.|||||.||||||.:|.|:.|.|::.:...||.::|:.|..:||.||..|..|||:::..:
  Rat   472 KFVIFNELSNARNPNNMQILYTVLQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTK 536

  Fly   485 FDVNLVKFCKTFLSEREDLTPQIEMFEFKERIFNSMVDIVCLCMFLSATPQAREASLSLKTNRDT 549
            .::|...||...:.||::  ||....|||||....:.|::.:.|.|..|.|.:||.::  .::..
  Rat   537 HEINFQAFCLGLMQERKE--PQYLEMEFKERFVVHITDVLAVSMMLGITAQVKEAGVA--WDKGE 597

  Fly   550 KNNHALLKLY-NQMSQIQLDTVSWMYETVPTLFKIPAAEYHQALHKLLLLDSPEQYSRCDQWPSE 613
            |.|..:|:.: ||::.||.|.|.|::..||::.|:...:|...|||:|..:.||.|.:.|.||.|
  Rat   598 KRNLEVLRTFQNQIAAIQRDAVWWLHTVVPSISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPE 662

  Fly   614 PERGAILRIISETPIHEETLLRIILIGITKDIPFSIANTFDVLLLVIKRVSGMKATNIPAVQANK 678
            .:|...||:.||.||.|:||:||::||:::::|...|:..::...::||.:.::|.::..::..:
  Rat   663 SDRNFFLRLCSEVPILEDTLMRILVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVER 727

  Fly   679 FDIIDFLFSMSEYHHPENIRLPAEYEPPKLAIIAFYWKAWLILLMISAHNPSSFGAFCWDHYPTM 743
            ..:||.:.::..|||||||:||..|:||.|||...|||||.:||:::|.||.:.|...|:.|||:
  Rat   728 IQLIDAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTL 792

  Fly   744 KMMMEICITNQFNNSSAT-----------KDELQIITMERDHILQFETYLAAQTSPHAVITEETA 797
            ||:||:.:||.::....|           ..||||...|:..||.||.:||| .|....|||.::
  Rat   793 KMLMEMVMTNNYSYPPCTLTDEETRTEMINRELQISQREKQEILAFEGHLAA-ASTKQTITESSS 856

  Fly   798 ILITQLMLMDPMGTPRKVPSMVLDQLKFLNQTYKLGHLFCRCRKPDLLLDIIQRQGTTQSMPWLS 862
            :|::||..:||.|.||:.|..:|||:|.|||:.:||||.||.|.||.||.|||||.::||||||:
  Rat   857 LLLSQLTSLDPQGPPRRPPPHILDQVKALNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLA 921

  Fly   863 DLVQNSEGDFSHLPVQCLCEFLLFNAHIINEENSRDAE-------------------LVNFLRNL 908
            ||||:|||....|||||||||||.:|.........|.|                   |:..|::|
  Rat   922 DLVQSSEGSLDVLPVQCLCEFLLHDAADATASGEEDDEGESREQKAKKRQRQQKQRQLLGRLQDL 986

  Fly   909 IFDGNLSHQIVCELLDYIFRRLSSTVKQSRVAALSGLKIIFRHSG--DFEN-------------- 957
            :.......|..||:|||..|||.|:...|||.|:.||.::....|  |.|.
  Rat   987 LLGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGGLRDKEEKEPPMEEDVGEADA 1051

  Fly   958 ----EWLLKSLQQIPHFYEVKPFIIPQLRAACQVENCPELIMAYIQFITAHTLNDPVNEMLDH-- 1016
                :|||:.|.::|.|..|:......|:.|..:|..|:.|.||:.:::.||   ||.|...|
  Rat  1052 LQGYQWLLRDLPRLPLFDSVRTTTALALQQAIHMETDPQTISAYLIYLSQHT---PVEEQGPHSD 1113

  Fly  1017 -VIDMAQLIVERSTMFQHIIISQEDYDYVPDENRIQTLKCLFVMFNNYIIKLR---EYHEPYEWT 1077
             .:|:|:|:|||||:..| :.|:.......|    ..|..|..:|:.|:.::|   |..|.|.|:
  Rat  1114 LALDVARLVVERSTIMAH-LFSKPSCSTASD----AVLSALLSVFSRYVRRMRKSKEGEEVYSWS 1173

  Fly  1078 EYPDLLMVQFDDGVQLPLHINIIHAFIILLTYS--NSNMPESIPILDYWFPPGRPAPVAFLPSMP 1140
            |..|.:.:::..|....:||.::||.:||||..  .|...|...:||.|||..:|.|.|||....
  Rat  1174 ESQDQVFLRWTSGETATMHILVVHAMVILLTLGPPRSGDSEFSELLDIWFPEKKPLPTAFLVDTS 1238

  Fly  1141 QEQVQLLPDWLKLKMIRSSVDRLIEAALNDLTPDQIVLFVQNFGTPVNSMSKLLAMLDTAVLEQF 1205
            :|.: ||||||||:||||.|.||::|||.||.|.|::||||:||.||:||||||..||.||.:..
  Rat  1239 EEAL-LLPDWLKLRMIRSEVPRLVDAALQDLEPQQLLLFVQSFGIPVSSMSKLLQYLDQAVAQDP 1302

  Fly  1206 DLVKNAILNKAYLAQLIEIQQARGAKNGHYTVQALDLHSHSQTVPDLPKISVVIQEAVEIDDYDS 1270
            ..::..|::|.|:|.|:|:|..|||..|.        ..||.....||.    .:::.|....:|
  Rat  1303 QTLEQNIMDKNYMAHLVEVQHERGASGGQ--------TFHSLLTASLPP----RRDSTEAPKPES 1355

  Fly  1271 S--------------------DSDDRPTNFLATKEVAQTILTQPD---QLTESRSDCRSLIQKLL 1312
            |                    ..||....||      |.....||   |.:..|....:|.|.|.
  Rat  1356 SPEPPPGQGRTRAGTQVPVLGPEDDLAGIFL------QIFPLSPDPRWQSSSPRPLALALQQALG 1414

  Fly  1313 DMLASPNSNRADVVNAITEVLAVGCSVTMSRHACT------------------------------ 1347
            ..||.......:|......:|....::..|.|..|
  Rat  1415 QELARVRQGNPEVPGITVRLLQAMATLLSSPHGGTLALAMHHSHFLSCPLMRQLCQYQRAVPQDT 1479

  Fly  1348 -----FLRTFFSCMLHSDKYHILENALQKNLSMF------KHTFAD--SSLLQKSEL--YHESLV 1397
                 ||:.....:...|...:.:..||..|.:|      :...:|  |.||..:|.  :|..|.
  Rat  1480 GFSSLFLKVLMQILQWLDSPAVEDGPLQAQLKLFATRYSARRRISDVRSGLLHLAEALSFHRDLE 1544

  Fly  1398 FMLRNSREIYA-----QQFKANTALVARKRIVRAIVQ----SFD--------------------- 1432
            .....:|.:.|     ::......|::  :::|.:::    .|:
  Rat  1545 VANSTARAVIATLRSGEKCTVEPELIS--KVLRGLIEVRSPHFEELLTALFSATAETCPSPASGP 1607

  Fly  1433 ---------QTKD-----SKTVAKSKSDQLFH----NGLFIDWLSEMDPEIV-STQLMKERFLFS 1478
                     |.:|     |...|:..|.:...    :||.:|||..:|||:| |...::.:.|||
  Rat  1608 IVVVSSLLLQERDEPLGPSTQDAEGASTEAMRLGPASGLLVDWLETLDPEVVCSCPDLQWKLLFS 1672

  Fly  1479 K---------SCSEFRFYLLSLINHQTNWDTIERIAEYLF-KNFHEDYDYATVLNYFEALTTNPK 1533
            :         ....||.|||:|:.||.:|.|:.|....|. |:..:..|.:..|::..|....|:
  Rat  1673 RRKGKGHISAQVLSFRPYLLALLTHQASWSTLHRCTRVLLSKSREQRLDPSASLDFLWACIHVPR 1737

  Fly  1534 LWKGRDKYMSKNVRPDAFFMLRTSELEPFSHFILHEGLSEVKLDSKNYDFK----LCSRMNLLFK 1594
            :|:|||:...:..|.:....::..||......|    |||.:..|::.|..    :.:|:.||..
  Rat  1738 IWQGRDQRTPQKRREELVLHVQGPELLSLVELI----LSEAETRSQDGDSAARTLIQTRLPLLLS 1798

  Fly  1595 LTEKRRDLMVKVMEHVEK------SSVSDYLKLQVLQQMYIMYPRIKFLKP-------GKTGEQA 1646
            ......:.:.||.||:..      .||.......:|.|:|:..|.::...|       |.|....
  Rat  1799 CCRSNDESIGKVTEHLTSCIQQWGDSVLGQRCRDLLLQLYLQRPEVRVPVPEVLLQSEGATSSSI 1863

  Fly  1647 YKLQNLKGCQADKVSNNLITCLGSLVGKKDFETLSTDTELLLRKLAASHPLLFLRQLGVLSSIMQ 1711
                    |:.|.:.:..||.|......:..|:...|..:..||||.:||:|.||.|.::::::.
  Rat  1864 --------CKLDGLIHRFITLLADTSDSRSSESRVADANMACRKLAVAHPILLLRHLPMIAALLH 1920

  Fly  1712 GRAQLSMKALREEHHFHRFVQILRTLELLQPTIFEEAYKNEIQNTLSCYFN-FFKHHSNVKEACQ 1775
            ||..|:.:..|:::|...::.:|..||||||.:|:..::..:.:.|..:.. ...:..:.::...
  Rat  1921 GRTHLNFQEFRQQNHLAFYLHVLGILELLQPRVFQSEHQGALWDCLRSFIRLLLNYRKSSRQLAP 1985

  Fly  1776 MLNKFVQMLQAYINYNPSSALLFIEQYVGILKELAAKYTSLGKLQVLVQAVALLQHKSHSATELD 1840
            .::||||.:..|:..:..:|:.|::::...|.:|:...:.|..|:.|:..::|......:...||
  Rat  1986 FISKFVQFIHKYVACSAPAAVAFLQKHAEPLHDLSFDNSDLVMLKSLLAGLSLPSRDGRADQGLD 2050

  Fly  1841 DE-EVKYEYDLDEHFDVKPSASKPVVTEDPIEVNPQTPIDPSSSRGPLSVLTLGSYSRSNYTDIS 1904
            :| |.|       ..|.:.:.|.|:|:     |:..||:                    ...|::
  Rat  2051 EEGEGK-------RADERSAGSLPLVS-----VSLSTPL--------------------TVADVA 2083

  Fly  1905 PHFLDLVKIIKQSNTEDVVLGPMQELECLTSKRFVFINELFERLLNLIFSPSAQIRSIAFIILIR 1969
            ||    :|.:.:....:.||..:.:::.::.:|...:......|..|:.|.....|::||.:.:|
  Rat  2084 PH----MKRLSRGQAVEDVLETLSDIDEMSRRRPEVLGFFSTNLQRLMSSAEESCRNLAFSLALR 2144

  Fly  1970 HLKHNPGNSDINLCTLNAYIQCLRDENSSVAATAIDNLPEMSVLLQEHAIDILTVAFSLGLKSCL 2034
            .:::||   .|....|..::.||...:..|..||:.||||.::|.||||..:|..||.:|:...:
  Rat  2145 SIQNNP---SIAADFLPTFMYCLGSRDFEVVQTALRNLPEYTLLCQEHAAVLLHRAFLVGMYGQI 2206

  Fly  2035 NTGHQIRKVLQTL 2047
            :|..||.:.|:.|
  Rat  2207 DTSAQISEALKIL 2219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS1	NP_611875.1	DUF3677	327..407	CDD:289217	35/79 (44%)
Ints1	XP_038945895.1	DUF3677	379..459	CDD:403584	35/79 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351292
Domainoid	1	1.000	138	1.000	Domainoid score	I4718
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H53111
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178763at33208
OrthoFinder	1	1.000	-	-		FOG0006612
OrthoInspector	1	1.000	-	-		otm45937
orthoMCL	1	0.900	-	-		OOG6_107095
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5610
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750