Protein Alignment IntS1 and INTS1

DIOPT Version :9

• Sequence 1: NP_611875.1
• Gene: IntS1 / 37840
• FlyBaseID: FBgn0034964
• Length: 2053
• Species: Drosophila melanogaster
• Sequence 2: XP_016867448.1
• Gene: INTS1 / 26173
• HGNCID: 24555
• Length: 2251
• Species: Homo sapiens
• Alignment Length: 2348
• Identity: 716/2348 - (30%)
• Similarity: 1131/2348 - (48%)
• Gaps: 404/2348 - (17%)

  Fly     1 MDRGKGSGSNR-SQKKVPLG----GELFALG-KSVRDDSKSKILPIKGMSS---SDRKREASTAL 56
            |:|.|.:...| |....|.|    |:..||| |...::||:....:|...|   |:|||:|:.||
Human     1 MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRDAAAAL 65

  Fly    57 ASSS------KRFR----------GNLKDAGAPDMSSGSSQCETWEQFAVDCD-LDTVV--ETIY 102
            :|:|      ||.:          |.|.:|...:..:.|...:  |...|..: |.||:  |...
Human    66 SSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIK--EPSVVPIEVLPTVLLDEIEA 128

  Fly   103 AALEQNDSETVGRLVCGVIKQTTTSSSRSKVDNIALLALIYVAKVQPSIFCTDIVACALLSFLRR 167
            |.||.||....| ::||.:||...  :|:|.|:...|:|:|:||::|:||.|:.|..||.|.|||
Human   129 AELEGNDDRIEG-VLCGAVKQLKV--TRAKPDSTLYLSLMYLAKIKPNIFATEGVIEALCSLLRR 190

  Fly   168 EA--NVKMRYNTNLHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICA 230
            :|  |.|.:.|:.:.:|..|||...:.|...|||:.:::||:|::.||.|.|:..|...|.||..
Human   191 DASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCKTFVDNIQT 255

  Fly   231 AFKTRTPHISLL----RWDVSSSLPSGQAHRDSMTVDDDSGDNSTQSLDASPLNTESEPIPDAMC 291
            ||.||.|..|:|    ...|:..|.:|.:...|:|.::||   .|:.|.|     |.:..|:...
Human   256 AFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDS---QTELLIA-----EEKLSPEQEG 312

  Fly   292 TTKSRFSDAV--VQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWIHN 354
            ....|:.:..  |:::|.|.:|||||:||..||.:||.|:.|.:|.|..|||.|::.:||:|:.|
Human   313 QLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGYKEVRLLAVQKLEMWLQN 377

  Fly   355 GKLVKFAQQLLSYICFNIKGRNTQDNEVLLVLVKMRLKTKPLINHYMSCLKEMIFLQPEILSTVM 419
            .||.:.||.||..:|.|.....::|.:|:..|:|:|||.|.|:||:|.|::|::....:.|.|.:
Human   378 PKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLLNHFMLCIRELLSAHKDNLGTTI 442

  Fly   420 KLVVQNELSNTRNPNNMGMLATMFQTSADQSAATLAEIYQEFLLQRDDCLRTLRVFLRELVRMLR 484
            |||:.||||:.||||||.:|.|..|.|::.:...||.::|:.|..:||.||..|..|||:::..:
Human   443 KLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTK 507

  Fly   485 FDVNLVKFCKTFLSEREDLTPQIEMFEFKERIFNSMVDIVCLCMFLSATPQAREASLSLKTNRDT 549
            .::|...||...:.||::  ||....|||||....:.|::.:.|.|..|.|.:||.::  .::..
Human   508 HEINFQAFCLGLMQERKE--PQYLEMEFKERFVVHITDVLAVSMMLGITAQVKEAGIA--WDKGE 568

  Fly   550 KNNHALLKLY-NQMSQIQLDTVSWMYETVPTLFKIPAAEYHQALHKLLLLDSPEQYSRCDQWPSE 613
            |.|..:|:.: ||::.||.|.|.|::..||::.|:...:|...|||:|..:.||.|.:.|.||.|
Human   569 KRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPE 633

  Fly   614 PERGAILRIISETPIHEETLLRIILIGITKDIPFSIANTFDVLLLVIKRVSGMKATNIPAVQANK 678
            .:|...||:.||.||.|:||:||::||:::::|...|:..::...::||.:.::|.::..::..:
Human   634 SDRNFFLRLCSEVPILEDTLMRILVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGR 698

  Fly   679 FDIIDFLFSMSEYHHPENIRLPAEYEPPKLAIIAFYWKAWLILLMISAHNPSSFGAFCWDHYPTM 743
            ..:||.:.::..|||||||:||..|:||.|||...|||||.:||:::|.||.:.|...|:.|||:
Human   699 TQLIDAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTL 763

  Fly   744 KMMMEICITNQFNNSSAT-----------KDELQIITMERDHILQFETYLAAQTSPHAVITEETA 797
            ||:||:.:||.::....|           ..|||....|:..||.||.:||| .|....|||.::
Human   764 KMLMEMVMTNNYSYPPCTLTDEETRTEMLNRELQTAQREKQEILAFEGHLAA-ASTKQTITESSS 827

  Fly   798 ILITQLMLMDPMGTPRKVPSMVLDQLKFLNQTYKLGHLFCRCRKPDLLLDIIQRQGTTQSMPWLS 862
            :|::||..:||.|.||:.|..:|||:|.|||:.:||||.||.|.||.||.|||||.::||||||:
Human   828 LLLSQLTSLDPQGPPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLA 892

  Fly   863 DLVQNSEGDFSHLPVQCLCEFLLFNA---HIINEEN----------------SRDAELVNFLRNL 908
            ||||:|||....|||||||||||.:|   ....||:                .:..:|:..|::|
Human   893 DLVQSSEGSLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDL 957

  Fly   909 IFDGNLSHQIVCELLDYIFRRLSSTVKQSRVAALSGLKIIFRHS----------------GDFE- 956
            :.......|..||:|||..|||.|:...|||.|:.||.::....                ||.:
Human   958 LLGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDTDV 1022

  Fly   957 ---NEWLLKSLQQIPHFYEVKPFIIPQLRAACQVENCPELIMAYIQFITAHTLNDPVNEMLDH-- 1016
               .:|||:.|.::|.|..|:......|:.|..:|..|:.|.||:.:::.||   ||.|...|
Human  1023 LQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHT---PVEEQAQHSD 1084

  Fly  1017 -VIDMAQLIVERSTMFQHIIISQEDYDYVPDENRIQTLKCLFVMFNNYIIKLR---EYHEPYEWT 1077
             .:|:|:|:|||||:..|:.....     |.......|..|..:|:.|:.::|   |..|.|.|:
Human  1085 LALDVARLVVERSTIMSHLFSKLS-----PSAASDAVLSALLSIFSRYVRRMRQSKEGEEVYSWS 1144

  Fly  1078 EYPDLLMVQFDDGVQLPLHINIIHAFIILLTYS--NSNMPESIPILDYWFPPGRPAPVAFLPSMP 1140
            |..|.:.:::..|....:||.::||.:||||..  .::..|...:||.|||..:|.|.|||....
Human  1145 ESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPLPTAFLVDTS 1209

  Fly  1141 QEQVQLLPDWLKLKMIRSSVDRLIEAALNDLTPDQIVLFVQNFGTPVNSMSKLLAMLDTAVLEQF 1205
            :|.: ||||||||:||||.|.||::|||.||.|.|::||||:||.||:||||||..||.||....
Human  1210 EEAL-LLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSKLLQFLDQAVAHDP 1273

  Fly  1206 DLVKNAILNKAYLAQLIEIQQARGAKNGHYTVQALDLHS-----------HSQTVPDLP----KI 1255
            ..::..|::|.|:|.|:|:|..|||..|. |..:|...|           ..::.|:.|    :|
Human  1274 QTLEQNIMDKNYMAHLVEVQHERGASGGQ-TFHSLLTASLPPRRDSTEAPKPKSSPEQPIGQGRI 1337

  Fly  1256 SVVIQEAVEIDDYDSSDSDDRPTNFLATKEVAQTILTQPD---QLTESRSDCRSLIQKLLDMLAS 1317
            .|..|..|      ....||....||      |.....||   |.:..|....:|.|.|...||.
Human  1338 RVGTQLRV------LGPEDDLAGMFL------QIFPLSPDPRWQSSSPRPVALALQQALGQELAR 1390

  Fly  1318 PNSNRADVVNAITEVLAV---------GCSVTMSRH-----ACTFLR------------TFFSCM 1356
            ......:|......||..         |.::.||.|     ||..||            |.||.:
Human  1391 VVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLCQYQRCVPQDTGFSSL 1455

  Fly  1357 LHSDKYHILE---------NALQKNLSMFK------HTFAD--SSLLQKSE--LYHESLVFMLRN 1402
            .......:|:         ..|:..|.|..      ...:|  ..||:.:|  .:.:.|..:...
Human  1456 FLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGGLLRLAEALAFRQDLEVVSST 1520

  Fly  1403 SREIYA-----QQFKANTALVARKRIVRAIVQ------------SFDQTKDS-------KTVAKS 1443
            .|.:.|     :|......|::  ::::.:::            .|..|.|:       |.|...
Human  1521 VRAVIATLRSGEQCSVEPDLIS--KVLQGLIEVRSPHLEELLTAFFSATADAASPFPACKPVVVV 1583

  Fly  1444 KSDQLFH------------------------NGLFIDWLSEMDPEIVST----QLMKERFLFSK- 1479
            .|..|..                        :||.:|||..:|||:||:    ||   |.|||:
Human  1584 SSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVDWLEMLDPEVVSSCPDLQL---RLLFSRR 1645

  Fly  1480 ------SCSEFRFYLLSLINHQTNWDTIER-IAEYLFKNFHEDYDYATVLNYFEALTTNPKLWKG 1537
                  ....||.|||:|..||::|.|:.: |...|.|:..:.:|.:..|::..|....|::|:|
Human  1646 KGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVLLGKSREQRFDPSASLDFLWACIHVPRIWQG 1710

  Fly  1538 RDKYMSKNVRPDAFFMLRTSELEPFSHFILHEGLSEVKLDSKNYDFKLCS----RMNLLFKLTEK 1598
            ||:...:..|.:....::..||......|    |:|.:..|::.|...||    |:.||......
Human  1711 RDQRTPQKRREELVLRVQGPELISLVELI----LAEAETRSQDGDTAACSLIQARLPLLLSCCCG 1771

  Fly  1599 RRDLMVKVMEHVE------KSSVSDYLKLQVLQQMYIMYPRIKFLKP-------GKTGEQAYKLQ 1650
            ..:.:.||.||:.      ..||.......:|.|:|:..|.::...|       |......
Human  1772 DDESVRKVTEHLSGCIQQWGDSVLGRRCRDLLLQLYLQRPELRVPVPEVLLHSEGAASSSV---- 1832

  Fly  1651 NLKGCQADKVSNNLITCLGSLVGKKDFETLSTDTELLLRKLAASHPLLFLRQLGVLSSIMQGRAQ 1715
                |:.|.:.:..||.|......:..|....|..:..||||.:||||.||.|.::::::.||..
Human  1833 ----CKLDGLIHRFITLLADTSDSRALENRGADASMACRKLAVAHPLLLLRHLPMIAALLHGRTH 1893

  Fly  1716 LSMKALREEHHFHRFVQILRTLELLQPTIFEEAYKNEIQNTL-SCYFNFFK----HHSNVKEACQ 1775
            |:.:..|:::|...|:.:|..||||||.:|    ::|.|..| .|..:|.:    :..:.:....
Human  1894 LNFQEFRQQNHLSCFLHVLGLLELLQPHVF----RSEHQGALWDCLLSFIRLLLNYRKSSRHLAA 1954

  Fly  1776 MLNKFVQMLQAYINYNPSSALLFIEQYVGILKELAAKYTSLGKLQVLVQAVALLQHKSHSATELD 1840
            .:|||||.:..||.||..:|:.|::::...|.:|:...:.|..|:.|:..::|......:...||
Human  1955 FINKFVQFIHKYITYNAPAAISFLQKHADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLD 2019

  Fly  1841 DEEVKYEYDLDEHFDVKPSASKPVVTEDPIEVNPQTPIDPSSSRGPLSVLTLGSYSRSNYTDISP 1905
            :|.                                   :..||.|.|.::::..::.....:::|
Human  2020 EEG-----------------------------------EEESSAGSLPLVSVSLFTPLTAAEMAP 2049

  Fly  1906 HFLDLVKIIKQSNTEDVVLGP----------MQELECLTSKRFVFINELFERLLNLIFSPSAQIR 1960
            :    :|.:.:..|.:...||          :.:::.::.:|...::.....|..|:.|.....|
Human  2050 Y----MKRLSRGQTVEGESGPASPTPDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCR 2110

  Fly  1961 SIAFIILIRHLKHNPGNSDINLCTLNAYIQCLRDENSSVAATAIDNLPEMSVLLQ---------- 2015
            ::||.:.:|.::::|   .|....|..::.||..::..|..||:.||||.::|.|
Human  2111 NLAFSLALRSMQNSP---SIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQGEDWPPAQGP 2172

  Fly  2016 -----------------------------------------EHAIDILTVAFSLGLKSCLNTGHQ 2039
                                                     |||..:|..||.:|:...::...|
Human  2173 GSPRGGRRCVPRGLALGSPEVWSLRPGCCGQRDVQGPVSPTEHAAVLLHRAFLVGMYGQMDPSAQ 2237

  Fly  2040 IRKVLQTL 2047
            |.:.|:.|
Human  2238 ISEALRIL 2245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS1	NP_611875.1	DUF3677	327..407	CDD:289217	33/79 (42%)
INTS1	XP_016867448.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157324
Domainoid	1	1.000	814	1.000	Domainoid score	I67
eggNOG	1	0.900	-	-		E1_KOG4596
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H53111
Inparanoid	1	1.050	1025	1.000	Inparanoid score	I276
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46851
OrthoDB	1	1.010	-	-		D178763at33208
OrthoFinder	1	1.000	-	-		FOG0006612
OrthoInspector	1	1.000	-	-		oto90858
orthoMCL	1	0.900	-	-		OOG6_107095
Panther	1	1.100	-	-	LDO	PTHR21224
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3428
SonicParanoid	1	1.000	-	-		X5610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800