Protein Alignment IntS1 and ints1

DIOPT Version :9

• Sequence 1: NP_611875.1
• Gene: IntS1 / 37840
• FlyBaseID: FBgn0034964
• Length: 2053
• Species: Drosophila melanogaster
• Sequence 2: XP_002942086.3
• Gene: ints1 / 100380131
• XenbaseID: XB-GENE-5888682
• Length: 2186
• Species: Xenopus tropicalis
• Alignment Length: 2289
• Identity: 712/2289 - (31%)
• Similarity: 1132/2289 - (49%)
• Gaps: 351/2289 - (15%)

  Fly     1 MDRGKGSGSNRSQKKV-----PLGGELFALG-KSVRDDSKSK---ILPIKGMSSSDRKREASTAL 56
            |:|.|.:...|.....     |..|:..||| |....|||:.   :.|.....||:|||||:|.|
 Frog     1 MNRPKTAAVRRPSAAAKSSGHPPPGDFIALGSKGQNTDSKASSNLLKPAASGLSSERKREATTTL 65

  Fly    57 ASSS------KRFR----------GNLKDAGAPDMSSGSSQCETWEQFAVDCDLDTVVETIYAAL 105
            ||:|      ||.:          |.|.||...:..:.|...:......::....::::.|.|:.
 Frog    66 ASTSALTGLTKRPKLSSTPPLSALGKLADAAVAEKRAISPSIKEPSVVPIEVPPASLLDDIDASE 130

  Fly   106 EQNDSETVGRLVCGVIKQTTTSSSRSKVDNIALLALIYVAKVQPSIFCTDIVACALLSFLRREA- 169
            ...:.:.:..::||.:||  ...:|:|.|....|:|:|:||::|:||.|:.|..||.|.|||:|
 Frog   131 SDGNDDRIEGVLCGAVKQ--LKMNRAKPDPTLYLSLMYLAKMKPNIFATEGVIEALCSLLRRDAT 193

  Fly   170 -NVKMRYNTNLHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICAAFK 233
             |.|.:.|:.:.:|..|||...:.|...|||:.:::||:|::.||.|.|::.|...|.||..||.
 Frog   194 INFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSQHCKTFVDNIQTAFC 258

  Fly   234 TRTPHISLLRWD----VSSSLPSGQAHRDSMTVDDDSGDNSTQSLDASPLNTESEPIPDAMCTTK 294
            |:.|..|::...    .:..|.:|.:...||..::||        .:..|..|.:..|:......
 Frog   259 TKMPPKSMVLHSETGRTAGDLSAGNSPHPSMPDEEDS--------QSELLIAEEKLSPEDEGQVM 315

  Fly   295 SRFSDAV--VQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWIHNGKL 357
            .|:.:..  |:::..|.:|||||:||..||.:||.|:.|..|.|..|||.:::.|||:|:.|.||
 Frog   316 PRYDELAESVEEYALDMLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRMMAVQRLEMWLQNPKL 380

  Fly   358 VKFAQQLLSYICFNIKGRNTQDNEVLLVLVKMRLKTKPLINHYMSCLKEMIFLQPEILSTVMKLV 422
            .:.||:||..:|.|......:|.||:..|:|:|||.|.|:||||..::|::....:.|.|::|.|
 Frog   381 TRPAQELLMSVCMNCNTHGPEDMEVISNLIKIRLKPKVLLNHYMLSVRELLNAHRDNLGTLVKFV 445

  Fly   423 VQNELSNTRNPNNMGMLATMFQTSADQSAATLAEIYQEFLLQRDDCLRTLRVFLRELVRMLRFDV 487
            :.|||||.||||||.:|.|:.|.|::.:...||.::|:.|..:||.||..|..|||:::..:.::
 Frog   446 IFNELSNARNPNNMQVLYTVLQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTKHEI 510

  Fly   488 NLVKFCKTFLSEREDLTPQIEMFEFKERIFNSMVDIVCLCMFLSATPQAREASLSLKTNRDTKNN 552
            |...||...:.||::  .|....|||||....:.|::.:.|.|..|.|.:||.::.... :.||.
 Frog   511 NFQAFCLGLMQERKE--AQYTDMEFKERFVIHITDLLAVSMMLGITAQVKEAGVAWDKG-EKKNL 572

  Fly   553 HALLKLYNQMSQIQLDTVSWMYETVPTLFKIPAAEYHQALHKLLLLDSPEQYSRCDQWPSEPERG 617
            ..|....||::.||.|.|.|::..|||:.|:...:|...|||:|..:.||.|.:.|.||.|.:|.
 Frog   573 EVLRSFQNQIAAIQRDAVWWLHTVVPTICKLSPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRN 637

  Fly   618 AILRIISETPIHEETLLRIILIGITKDIPFSIANTFDVLLLVIKRVSGMKATNIPAVQANKFDII 682
            ..||:.||.|:.|:||:||::||:::|:|...|:..::...::||.:.::|.::..::..:..::
 Frog   638 FFLRLCSEVPLLEDTLMRILVIGLSRDLPLGPADAMELADHLVKRAAAVQADDLEVLRIERIQLL 702

  Fly   683 DFLFSMSEYHHPENIRLPAEYEPPKLAIIAFYWKAWLILLMISAHNPSSFGAFCWDHYPTMKMMM 747
            |.:.::..|||||||:||..|:||.|||...|||||.:||:::|.||.:.|...|:.|||:||:|
 Frog   703 DAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENLGLAAWEEYPTLKMLM 767

  Fly   748 EICITNQFNNSSAT-----------KDELQIITMERDHILQFETYLAAQTSPHAVITEETAILIT 801
            |:.:||.::....|           ..||||...|:..||.||::||| .|....|||..::|::
 Frog   768 EMVMTNNYSFPPCTVTEEETRTEIINRELQISQREKQEILAFESHLAA-ASTKQTITESNSLLLS 831

  Fly   802 QLMLMDPMGTPRKVPSMVLDQLKFLNQTYKLGHLFCRCRKPDLLLDIIQRQGTTQSMPWLSDLVQ 866
            ||..:||.|.||:.|...::|:|.|||:.:||||.||.|.||.||:|||||.::||||||:||||
 Frog   832 QLTSLDPQGPPRRPPPHAIEQVKSLNQSLRLGHLLCRSRNPDFLLNIIQRQASSQSMPWLADLVQ 896

  Fly   867 NSEGDFSHLPVQCLCEFLLFNAHIIN------EEN-------------SRDAELVNFLRNLIFDG 912
            :|||....|||||||||||.:|...:      |||             .:..:|:..|::|:...
 Frog   897 SSEGSLDVLPVQCLCEFLLHDAADESGTGEDEEENESKEQRAKKQQRQQKQRQLLGRLQDLLLGP 961

  Fly   913 NLSHQIVCELLDYIFRRLSSTVKQSRVAALSGLKIIF----------------RHSGDFE----N 957
            ....|..||:|||..|||||....|||.|:.||.::.                ..|||.|    .
 Frog   962 KADEQTTCEVLDYFLRRLSSPQVASRVLAMKGLSMVLSEKGLRDTDDKDQSMDEDSGDSELMQGY 1026

  Fly   958 EWLLKSLQQIPHFYEVKPFIIPQLRAACQVENCPELIMAYIQFITAHTLNDPVNEMLDH---VID 1019
            :|||:.|..:|.|..||......|:.|..:|...:.|.||:.:::.|.   |:.:...|   .:|
 Frog  1027 QWLLRDLPNLPLFESVKGTTAVALQQAIHMETDLQTISAYLVYLSEHA---PIEDQAQHNDLALD 1088

  Fly  1020 MAQLIVERSTMFQHIIISQEDYDYVPDENRIQTLKCLFVMFNNYIIKLR---EYHEPYEWTEYPD 1081
            :|:|||||||:..|:.   ....|..:.:.:  |..|..:|:.::.::|   |..|.|.|:|..|
 Frog  1089 VARLIVERSTIMSHLF---SKLSYCSESSAV--LAALLSIFSCFVRRMRKSKEGDEVYSWSESQD 1148

  Fly  1082 LLMVQFDDGVQLPLHINIIHAFIILLTYS-NSNMPESIPILDYWFPPGRPAPVAFLPSMPQEQVQ 1145
            .:.:::..|....:||.::||.:||||.. .....:...:||.|||..:|.|.|||....:|.:
 Frog  1149 QVFLRWSSGETATMHILVVHAMVILLTLGPPRGESDFFALLDIWFPEKKPLPTAFLVDTSEEAL- 1212

  Fly  1146 LLPDWLKLKMIRSSVDRLIEAALNDLTPDQIVLFVQNFGTPVNSMSKLLAMLDTAVLEQFDLVKN 1210
            ||||||||:||||.|.||::|||:||.|.|::||||:||.||:||||||..||.||.::...::.
 Frog  1213 LLPDWLKLRMIRSEVPRLVDAALHDLEPQQLLLFVQSFGIPVSSMSKLLQYLDQAVSQEPQALEQ 1277

  Fly  1211 AILNKAYLAQLIEIQQARGAKNGHYTVQALDLHSHSQTVPDLPKISVVIQEAVEIDDYDSSD--- 1272
            .|::|.|:|.|:|:|..|||..|             ||...|...|:..:.       ||::
 Frog  1278 NIMDKNYMAHLVEVQHERGATGG-------------QTFHSLLTASIPPRR-------DSTELIK 1322

  Fly  1273 ---SDDRPTNFLATKEVAQTILTQPD--------QLTESRSDCR-----------SLIQKLLDML 1315
               |.:.|...:..:.|.|..:..|:        ||.....|.|           :|.|.|...|
 Frog  1323 RKASTETPQGQVRARAVTQIPVLGPEDDLAGMFLQLFPLNPDPRWQNFNPRPISLALQQALGQEL 1387

  Fly  1316 ASPNSNRADVVNAITEVL-AVGC--------SVTMSRH-----ACTFLR---------------- 1350
            |........:......:| |||.        ::.::.|     ||..:|
 Frog  1388 ARIRQGNTQLTGIAVRLLQAVGALLNSPHSGALVLAMHRNHFIACPLMRLLYQYQRSVPQDTAFS 1452

  Fly  1351 -TFFSCMLHS----DKYHILENALQKNLSMF------KHTFAD---------------------- 1382
             .||..::..    |...:.|..|:..|..|      ||..:|
 Frog  1453 SLFFKVLMQMLQWLDSPGVEEGPLRAQLKSFAALYSSKHRISDVRSGFLHLAEALAFCREPDVIN 1517

  Fly  1383 -----------------------SSLLQ-----KSELYHESLVFMLRNSREIYAQQFKAN----- 1414
                                   |.:||     ||....|.|..:|..:.|. ..:|.|.
 Frog  1518 STIRTIITTLKSGDKCNVEPELISKVLQGLIEAKSPYLEEFLTVLLSVTIET-TSRFTATGPVAL 1581

  Fly  1415 -TALVARKRIVRAIVQSFDQTKDSKTVAKSKSDQLFHNGLFIDWLSEMDPEIVST-QLMKERFLF 1477
             ::|:.::| ..:.::..:::..|:|.....|     :||.||||..:|||::|: ..:::|.||
 Frog  1582 VSSLLLQER-QESSIKKGNESCSSETARSYPS-----SGLLIDWLELLDPEVISSFPDLQQRLLF 1640

  Fly  1478 S--KSCS-----EFRFYLLSLINHQTNWDTIER-IAEYLFKNFHEDYDYATVLNYFEALTTNPKL 1534
            |  |..|     .||.|||:|:.||:||.|:.: ||..|.|...:.:|.:..|::..|....|::
 Frog  1641 SWNKGSSALQPPSFRPYLLALLTHQSNWTTLHQCIAILLSKQREQRFDPSASLDFLWACIHIPRI 1705

  Fly  1535 WKGRDKYMSKNVRPDAFFMLRTSELEPFSHFILHEGLSEVKLDSKNYDFKLC----SRMNLLFKL 1595
            |:|||:...:..|.:....|:.|||......|    :||.:...:..:...|    ||:.||...
 Frog  1706 WQGRDQRTPQKRRDEYVLRLKQSELLCLVDLI----ISEAETRGQGSEEIACPLIQSRLPLLINS 1766

  Fly  1596 TEKRRDLMVKVMEHV-------EKSSVSDYLKLQVLQQMYIMYPRIKFLKPG--KTGEQAYKLQN 1651
            .:..::.:.|||||:       ..||:..:.: ..|.|:|:..|.:....|.  .|.|.|   .:
 Frog  1767 CQGDQENIKKVMEHLISCIKQWGNSSLGKHCR-DFLLQLYLQLPELILPVPDILLTSEGA---TD 1827

  Fly  1652 LKGCQADKVSNNLITCLGSLVGKKDFETLSTDTELLLRKLAASHPLLFLRQLGVLSSIMQGRAQL 1716
            ...|:.|.:.:..||.|......|  |:..:|..:..||||.:||||.||.|.::::::.|||.|
 Frog  1828 SSTCKMDALIHRFITLLADTSDCK--ESRMSDANMACRKLAVAHPLLLLRHLPMIAALLHGRAHL 1890

  Fly  1717 SMKALREEHHFHRFVQILRTLELLQPTIFEEAYKNEIQNTL-SCYFNFFKHHSNVKEACQML--- 1777
            :....|:::|...|..:|..||||||.:|.    :|.|..| .|..:|.|...|.::..:.|
 Frog  1891 NFHEFRQQNHLTFFTHVLGILELLQPQVFH----SERQEALWDCLVSFIKVLQNYRKYSRQLAAF 1951

  Fly  1778 -NKFVQMLQAYINYNPSSALLFIEQYVGILKELAAKYTSLGKLQVLVQAVALLQHKSHSATELDD 1841
             :||||.:..||..:..:|:.|:::....|..|:::.:.|..|:.|:..::|  .....|.|...
 Frog  1952 ISKFVQFIHKYITCDAQAAVSFLQKNSDPLHGLSSENSDLSMLKSLLAGLSL--PSRGGAQEKTS 2014

  Fly  1842 EEVKYEYDLDEHFDVKPSASKPVVTEDPIEVNPQTPIDPSSSRGPLSVLTLGSYSRSNYTDISPH 1906
            ||.|                                 |..|:.|.|..:::..::.....:::|:
 Frog  2015 EEEK---------------------------------DEESTTGSLPFVSVSMFTPLTAAEMAPY 2046

  Fly  1907 FLDLVKIIKQSNTEDVVLGPMQELECLTSKR---FVFINELFERLLNLIFSPSAQIRSIAFIILI 1968
               |.:|.:..:.|| :|..:.:::.::.:|   ..|....|:||::   |.....|::||.:.:
 Frog  2047 ---LKRISRSKSVED-ILQALSDIDEMSKRRPEILSFFASDFQRLMS---STEESCRNLAFSLAL 2104

  Fly  1969 RHLKHNPGNSDINLCTLNAYIQCLRDENSSVAATAIDNLPEMSVLLQEHAIDILTVAFSLGLKSC 2033
            |.::.||   .|....|..::.||...:..|..||:.||||.::|.||||..:|..||.:|:...
 Frog  2105 RTVQCNP---SIAADFLPTFMYCLGSRDFEVVQTALRNLPEYTLLCQEHAAVLLHRAFLVGMYGQ 2166

  Fly  2034 LNTGHQIRKVLQTL 2047
            ::|..||.:.|:.|
 Frog  2167 MDTSPQISEALKVL 2180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS1	NP_611875.1	DUF3677	327..407	CDD:289217	34/79 (43%)
ints1	XP_002942086.3	DUF3677	350..430	CDD:403584	34/79 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H53111
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178763at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010