DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ1 and KCNQ

DIOPT Version :9

Sequence 1:	NP_000209.2	Gene:	KCNQ1 / 3784	HGNCID:	6294	Length:	676	Species:	Homo sapiens
Sequence 2:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	262/697 - (37%)
Similarity:	363/697 - (52%)	Gaps:	188/697 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    87 LDPRVSIY--------STRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLS 143
            |.||:|:.        .|||.|..| .:|.|:|||||||.|.....||..|||:|..||..||.|
  Fly    31 LQPRMSLLGKPLNYNRGTRRDVRYR-RLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFS 94

Human   144 TIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVA 208
            ||::|...|...||.|||::|::|..|:..||||:||||:|.|..|||:|.::|..|||::.::|
  Fly    95 TIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILA 159

Human   209 SMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGL 273
            |:|||.:|:.||||||||:||:||.|||||:.:||:||||:||||||:.||||||||:|||||||
  Fly   160 SIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGL 224

Human   274 IFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAIS 338
            ||:|:.||:.||| ||:    :|.::|.||||||:|:.|:||||.||.||.||.||||.::..||
  Fly   225 IFASFLVYMWEKD-VND----KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGIS 284

Human   339 FFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSS--TWKI------- 394
            |||||||||||||||||||:|||||..|:...||:|||..||||||:....|  ||.|
  Fly   285 FFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPS 349

Human   395 ---------------YIRKAP-----RSHTLLSPS-------PKPKKSVVVKKKKFKLDKD---- 428
                           ::.:.|     :|.|:.:|.       .||..|.....:..:..:|
  Fly   350 PPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINAS 414

Human   429 --------NG--VTPGEKMLTVPHITC-----------------------------------DPP 448
                    ||  :.|.....:|...||                                   |..
  Fly   415 VENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRD 479

Human   449 EERRLDHFSVDGYDS-------SVRKSPTLLEVSMPHFMRTNSF-------------AEDLDLE- 492
            ::|| .|...:|..:       ..|::.| :.|.:..|:..|..             |.|.|||
  Fly   480 QDRR-GHGEGEGDQAEEQAKAGGSRRNLT-IPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEA 542

Human   493 --------------GETLLTPI---------------------THI------------------- 503
                          ..||..|:                     :|.
  Fly   543 GRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEED 607

Human   504 ----SQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLD 564
                :||...|:..|:.||:::||||::||::|.|||||:||:|||:.||::|:.|:|.|..|||
  Fly   608 EPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLD 672

Human   565 QSIGKPSLFISVSEKSKD--RGSNTIGARLNRVEDKVTQLDQRLALI 609
            |.:||.      ..|:||  ....::.:|:.:||.:|..::::|.::
  Fly   673 QILGKQ------GSKAKDVYASKISLASRVVKVERQVADIEEKLDIL 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ1	NP_000209.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..84
		Ion_trans	153..359	CDD:278921	131/205 (64%)
		Ion_trans_2	270..349	CDD:285168	49/78 (63%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000269\|PubMed:25441029	370..382		7/11 (64%)
		KCNQ_channel	<511..617	CDD:281513	40/101 (40%)
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000269\|PubMed:25441029	515..529		6/13 (46%)
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000269\|PubMed:25037568	535..572		21/36 (58%)
		Interaction with AKAP9. /evidence=ECO:0000269\|PubMed:11799244	588..616		5/22 (23%)
		C-terminal assembly domain. /evidence=ECO:0000269\|PubMed:10654932	589..620		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..676
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	132/209 (63%)
		Ion_trans_2	221..295	CDD:285168	49/78 (63%)
		KCNQ_channel	<619..719	CDD:281513	40/101 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	1	1.000	-	-		FOG0003178
OrthoInspector	1	1.000	-	-		otm51484
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760