Protein Alignment MAN1 and HEH2

DIOPT Version :10

• Sequence 1: NP_611873.1
• Gene: MAN1 / 37838
• FlyBaseID: FBgn0034962
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_010746.1
• Gene: HEH2 / 852069
• SGDID: S000002866
• Length: 663
• Species: Saccharomyces cerevisiae
• Alignment Length: 653
• Identity: 125/653 - (19%)
• Similarity: 208/653 - (31%)
• Gaps: 212/653 - (32%)

  Fly     7 NSLSDKELHRKLIQSGFPSTPVTETTRAVLIEKLRKHTRAD---------------KLKKRSNKY 56
            |:...|.|..|.::|....:...:.......::.|:....|               |.||||:|
Yeast    71 NADRKKTLKSKKLESSSSESKTVKDENVETNKRKREQISTDNEAKMQIQEEKSPKKKRKKRSSK- 134

  Fly    57 VLYSKEQQESPPFPQYHQYHAPQPPQNYANGLDNNNDLDQTGGSSAYNRSLDESDSSPLQLSASK 121
                   ...||         ..|||:.::|...:.||.....:.......|.||..|......|
Yeast   135 -------ANKPP---------ESPPQSKSDGKATSADLTSELETVEELHKKDSSDDKPRVKELPK 183

  Fly   122 MYAPPPVVAS----------------NYDGDCSPHSLGLNGKYLQPCSMPYAIDTSNNYGKPSGK 170
            ...|...|::                |||     ||:    |.....|:  .|:|....|..:|.
Yeast   184 PELPNLKVSNEFLAQLNKELASAATENYD-----HSI----KSTDLSSI--RIETEEPVGPSTGA 237

  Fly   171 AKLSDGGVVNRL-LSFRD---------TTIQRKF-NYPTGQASRIPLRKE------RLTRFALSD 218
            ...::..|:..: |..:.         |.|...| |......||:..:|.      |...|..:.
Yeast   238 ETRNESEVMENINLEVQPEVKEAKEELTKISETFDNQDEEDTSRLSSKKNIRSPKGRTRHFIANK 302

  Fly   219 LKSFIRNPDIRPYVIPRVLISLF--LIFLTII-TVLY----------VGKRFEQSPIDKAALK-Y 269
            .|   |..||....|..:.|.|:  .|||:|| .:|:          ||....:.|:...|:. :
Yeast   303 TK---RGIDIMKPFIAHLFIWLWNGAIFLSIICPILFGLWYREQRIQVGYCGHEKPLKSLAISAF 364

  Fly   270 TLCNPNDMQMISEKVNCIE---------------------KDSLRG-----------ALDMSEE- 301
            ......|..:.:.:.||:|                     |.|:..           |.|.|:|
Yeast   365 PQTERVDSVLQAYRPNCLECPEHGICSSFMNVECEPGYEPKSSILETYGIIPFPKYCAKDESKEK 429

  Fly   302 --------LFRHLNERARLHHCKDA-NLSPALEIGEFVREMVSNPKTHRGNLHSNLMAAKYLITE 357
                    :..:|.::...|.|.:. ||   .|.||      :..|.:....||
Yeast   430 EVDELVWKVNEYLKKKNAQHECGEGENL---FESGE------TETKLYDIFSHS----------- 474

  Fly   358 NPQWSIQ---------VVDSTKHL-------------GQTSHFELSEPN----------LPLKCI 390
            .|.|..|         |::..|..             |:....:.:..|          :.|:|.
Yeast   475 RPSWESQREFNDHWKNVLEILKKKDDIIWLPLDFETNGKREKSKSNNTNYIYRSTSKKWVTLQCH 539

  Fly   391 VLKKVTRFFTVIGALLLIVAG--FLIVYVAVVIYRVKQKEALLAVDQFQKDIINELIYLSSQSES 453
            :...:..:.|..|..|.|..|  |||..:...:....|.|.:  :::..|:.|::|
Yeast   540 LEGDIQEYITKYGGSLFITLGVLFLIKKIQSTLDNYVQGEQI--IEKLVKEAIDKL--------- 593

  Fly   454 PEVVINQLQEKFL-PAKKRSKLLSS----------WNKALKQLEKNDS-RVLFGMVNRDGKAMRT 506
            .:|..|:.:|.|| ..:.|:.|||.          |.:..:::.|..| .:...::..:|:.|..
Yeast   594 KDVKKNKGEEPFLTTVQLRATLLSDIPNIKEQNNLWAQTKEKIMKEQSENIELYLLEENGEIMTC 658

  Fly   507 IAW 509
            ..|
Yeast   659 WEW 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_611873.1	LEM	4..47	CDD:128813	6/39 (15%)
		RRM_Man1	542..631	CDD:409728
HEH2	NP_010746.1	LEM_like	8..42	CDD:240596
		MSC	330..661	CDD:430586	64/361 (18%)