Protein Alignment MAN1 and Lemd3

DIOPT Version :10

• Sequence 1: NP_611873.1
• Gene: MAN1 / 37838
• FlyBaseID: FBgn0034962
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_001177929.1
• Gene: Lemd3 / 680066
• RGDID: 1596822
• Length: 914
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 159/643 - (24%)
• Similarity: 253/643 - (39%)
• Gaps: 149/643 - (23%)

  Fly    85 ANGLDNNNDLDQTG---GSSAYNRSLDESDSSPLQLSASKMYA-----PPPVVASNYDGDCSP-- 139
            |..||.:.:|::..   |........|:.||.|...:.:|..|     |.|.|.|..:....|
  Rat   327 AGSLDRSRNLEEAAAEPGGGGGGGGCDQVDSIPRYRAGAKKLAPLLSPPSPDVDSTLESPTGPLK 391

  Fly   140 --HSLGLNGKYLQPCSMPYAIDTSNNYGK--PSGKAKLSDGGVVNRLLSFRDTTIQRKFNYPTGQ 200
              :.:|..|        .:.:|:.:.|..  |.|.|..:.|.:              :.|:....
  Rat   392 TNNHIGGGG--------AFGVDSPSLYANSIPPGAAATAPGSL--------------RINHANHT 434

  Fly   201 ASRIPLRKERLTRFALSD-----LKSFIRNPDIRP------YVIPRVLISLFLIFLTIITVLYVG 254
            .|.....|...::..|.:     |:.|.|. ::.|      :.:...|::...:|..|:.:.|:|
  Rat   435 GSNHTYLKNAYSKPKLCEPEEELLQQFKRE-EVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLG 498

  Fly   255 KRFEQSPIDKAALKYTLCNPNDMQMISEKVNCIEKDSLRGALDMSEELFRHLNERARLHHCKDAN 319
            .|....|.|...||    ||.|...  .|:...||:.:...|   .:|...|.:.|..|.|
  Rat   499 MRGTGVPEDGRLLK----NPFDETF--GKIQASEKNLMMSTL---YKLHDRLAQIAGDHEC---- 550

  Fly   320 LSPALEIGEFVREMVSNPKTHRGNLHSNLMAAKYLITENPQWS-------IQVVDSTKHLG---- 373
                   |...:.|:|..:           ||.||....|::.       :.:..:.|.:|
  Rat   551 -------GRSSQRMLSVQE-----------AAAYLKDLGPEYEDVFNTSLLWIFKNGKDVGIRCV 597

  Fly   374 ------------QTSHFELSEPNLPLKCIVLKKVTRFFTVIGALLLIVAGFLIVYVAVVI----Y 422
                        .....:.:.|.:|..|...:   .|.||...|||:..|  :|.|..|:    |
  Rat   598 GYGPEEDLTNITDVQFLQSTRPQMPFWCRFRR---AFITVTHRLLLLCLG--VVLVCAVLRYMRY 657

  Fly   423 R-VKQKEALLAVDQFQKDIINELIYLSSQSES--------PEVVINQLQEKFLPAKKRSKLLSSW 478
            | .|::|   ...|....::..:..|.|.:|:        |.:.|..:::..:..:.|.|:...|
  Rat   658 RWTKEEE---ETRQMYDMVVKIIDVLRSHNEACQETKDLQPYMPIPHVRDSLIQPQDRKKMKKVW 719

  Fly   479 NKALKQLEKNDSRVLFGMVNRDGKA----MRTIAWNRNVDKKDVGLVKKWQSPAF--DNSNKIAN 537
            .:|:..|..|:|||. ....|.|.|    .|.:..:.:.||..|...|.||..||  |..|...|
  Rat   720 ERAVDFLAANESRVR-TETRRVGGADFVVWRWVQPSASCDKTSVIPSKVWQGQAFHLDRRNSPPN 783

  Fly   538 PPTPCLKIRHMFDS-SEV-DQANLKQSIVESIIEKVGTRCKICDVQLDVQS--CCVYIRCASEED 598
            ..|||||||:|||. .|: |..:|  :|.|:|:||......|..:.:|..|  .|||::|.|...
  Rat   784 SLTPCLKIRNMFDPVMEIGDHWHL--AIQEAILEKCSDNDGIVHIAVDRNSREGCVYVKCLSPGH 846

  Fly   599 AGTIHKEINGWWFDKRLISIKFLRLERYLSRFP---------KPSAEPLYFHTNEAAN 647
            ||...|.::|.|||.:|:::|:|||:||..|||         |||.:    |.|..::
  Rat   847 AGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCSTPLKPSDK----HMNSMSH 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_611873.1	LEM	4..47	CDD:128813
		RRM_Man1	542..631	CDD:409728	39/92 (42%)
Lemd3	NP_001177929.1	LEM	12..50	CDD:470643
		PHA03247	143..>311	CDD:223021
		MSC	<534..751	CDD:430586	52/250 (21%)
		RRM_Man1	788..879	CDD:409728	39/92 (42%)