DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAN1 and Lemd3

DIOPT Version :9

Sequence 1:	NP_001286812.1	Gene:	MAN1 / 37838	FlyBaseID:	FBgn0034962	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001074662.2	Gene:	Lemd3 / 380664	MGIID:	3580376	Length:	918	Species:	Mus musculus

Alignment Length:	656	Identity:	164/656 - (25%)
Similarity:	251/656 - (38%)	Gaps:	177/656 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ANGLDNNNDLDQT----GGSSAYNRSLDESDSSPLQLSASKMYAP---PPVVASNYDGDCSPHS- 141
            |..||.:.:|::.    ||........|..||.|...:.:|..||   ||    :.|||.:..|
Mouse   329 AGSLDRSRNLEEAAAEPGGGGGGGCGCDPVDSIPRYRAGAKKLAPLLSPP----SPDGDSTLESP 389

  Fly   142 ---------------LGLNGKYLQPCSMP---------------YAIDTSNN-------YGKPSG 169
                           .|::...|...|:|               :|..|.:|       ||||
Mouse   390 TGPLLKTNNHIGGGAFGVDSPGLYANSLPPGATAAAAPGTLRINHANHTGSNHTYLKTAYGKP-- 452

  Fly   170 KAKLSDGGVVNRLLSFRDTTIQ---RKFNYPTGQASRIPLRKERLTRFALSDLKSFIRNPDIRPY 231
                       :|....:..:|   |:...|||.             |:...|..|
Mouse   453 -----------KLCEPEEELLQQFKREEVSPTGS-------------FSAHYLSMF--------- 484

  Fly   232 VIPRVLISLFLIFLTIITVLYVGKRFEQSPIDKAALKYTLCNPNDMQMISEKVNCIEKDSLRGAL 296
                 |::...:|..|:.:.|:|.|....|.|...:|    ||.|...  .|:...||:.|...|
Mouse   485 -----LLTAACLFFLILGLTYLGMRGTGVPEDGGLIK----NPFDETF--GKIQESEKNLLMSTL 538

  Fly   297 DMSEELFRHLNERARLHHCKDANLSPALEIGEFVREMVSNPKTHRGNLHSNLMAAKYLITENPQW 361
               .:|...|.:.|..|.|           |...:.|:|..:           ||.||....|::
Mouse   539 ---YKLHDRLAQIAGDHEC-----------GSSSQRMLSVQE-----------AAAYLKNLGPEY 578

  Fly   362 S-------IQVVDSTKHLG----------------QTSHFELSEPNLPLKCIVLKKVTRFFTVIG 403
            .       :.:..:.|.:|                .....:.:.|.:|..|...:   .|.||..
Mouse   579 EDVFNTSLLWIFKNGKDVGIRCVGYGPEEDLTNITDVQFLQSTRPQMPFWCRFRR---AFITVTH 640

  Fly   404 ALLLIVAGFLIVYVAVVIYRVKQKEALLAVDQFQKDIINELIYLSSQSES--------PEVVINQ 460
            .|||:..|.::|.||:...|.:..:......|....::..:..|.|.:|:        |.:.:..
Mouse   641 RLLLLCLGVVLVCVALRYMRYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQETKDLQPYMPLPH 705

  Fly   461 LQEKFLPAKKRSKLLSSWNKALKQLEKNDSRVLFGMVNRDGKA----MRTIAWNRNVDKKDVGLV 521
            :::..:..:.|.|:...|::|:..|..|:|||. ....|.|.|    .|.|..:.:.||..|...
Mouse   706 VRDSLIQPQDRKKMKKVWDRAVDFLAANESRVR-TETRRVGGADFLVWRWIQPSASCDKTLVIPS 769

  Fly   522 KKWQSPAF--DNSNKIANPPTPCLKIRHMFDS-SEV-DQANLKQSIVESIIEKVGTRCKICDVQL 582
            |.||..||  |..|...|..|||||||:|||. .|: |..:|  :|.|:|:||......|..:.:
Mouse   770 KVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDHWHL--AIQEAILEKCSDNDGIVHIAV 832

  Fly   583 DVQS--CCVYIRCASEEDAGTIHKEINGWWFDKRLISIKFLRLERYLSRFPKPSA--EPLYFHTN 643
            |..|  .|||::|.|.|.||...|.::|.|||.:|:::|:|||:||..|||:...  .||
Mouse   833 DRNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCNTPL----- 892

  Fly   644 EAANTH 649
            :.||.|
Mouse   893 KPANKH 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_001286812.1	LEM	4..47	CDD:128813
		MSC	<381..509	CDD:286487	33/139 (24%)
		RRM_Man1	542..631	CDD:240732	40/92 (43%)
Lemd3	NP_001074662.2	LEM	10..48	CDD:295412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..97
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..392		8/24 (33%)
		MSC	<576..755	CDD:286487	35/182 (19%)
		Interaction with SMAD1, SMAD2, SMAD3 and SMAD5. /evidence=ECO:0000250	706..918		74/201 (37%)
		RRM_Man1	792..883	CDD:240732	40/92 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0147
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D873705at2759
OrthoFinder	1	1.000	-	-		FOG0004711
OrthoInspector	1	1.000	-	-		oto92307
orthoMCL	1	0.900	-	-		OOG6_106535
Panther	1	1.100	-	-	LDO	PTHR13428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2606
SonicParanoid	1	1.000	-	-		X5852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740